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Biophysical Approaches To Human Genetic Disease: Adsl Deficiency As A Model, Stephen P. Ray
Biophysical Approaches To Human Genetic Disease: Adsl Deficiency As A Model, Stephen P. Ray
Electronic Theses and Dissertations
Biophysical tools are becoming more useful in approaching human genetic disease. The pathogenic mechanisms behind many disorders have been attributed to protein loss of function or gain in toxic function. For example, changes in the protein Adenylosuccinate Lyase (ADSL) lead to ADSL deficiency, a disorder that causes symptoms ranging from epilepsy to expression of autistic features. Biophysics offers different tools to study intrinsic properties of proteins. We have applied such tools to study the enzyme kinetics and protein stability of ADSL and two mutations (R426H and R303C) to formulate better hypotheses regarding the pathogenic mechanism. Enzyme kinetic findings indicate a) …
Celestial Paleontology: The Legacy Of Dying Stars, Alexa Hodgson Hart
Celestial Paleontology: The Legacy Of Dying Stars, Alexa Hodgson Hart
Electronic Theses and Dissertations
In their death throes, stars dole out their atmospheric material to the interstellar medium in dramatic stellar winds and spectacular explosions. The details of this profound metamorphosis, from star to remnant, play a key role in the next generation of star formation as well as the energetic and chemical evolution of galaxies and the universe as a whole. Dying stars are thought to be the source of all of the nuclei heavier than iron in the universe, as well as more complex molecules, such as carbon chains, which form the backbone of life as we know it.
High mass Wolf-Rayet …
The X-Ray And Spectropolarimetric View Of Mass Loss And Transfer In Massive Binary Stars, Jamie Renae Lomax
The X-Ray And Spectropolarimetric View Of Mass Loss And Transfer In Massive Binary Stars, Jamie Renae Lomax
Electronic Theses and Dissertations
The majority of massive stars are members of binary systems. In order to have a better understanding of their evolutionary pathways, the mass and angular momentum loss from massive binaries needs to be well understood. Self consistent explanations for their behavior need to be valid across many wavelength regimes in order to illuminate key phases of mass loss to completely determine how it affects their evolution. In this dissertation I present the results of X-ray and specropolarimetric studies on one Roche-lobe overflow binary (β Lyr) and two colliding wind binaries (V444 Cyg and WR 140).
In β Lyr a …
Oxide Semiconductors For Organic Opto-Electronic Devices, Ajaya Kanta Sigdel
Oxide Semiconductors For Organic Opto-Electronic Devices, Ajaya Kanta Sigdel
Electronic Theses and Dissertations
Development of transparent oxide semiconductors (TOS) from Earth-abundant materials is of great interest for cost-effective thin film device applications, such as solar cells, light emitting diodes (LEDs), touch-sensitive displays, electronic paper, and transparent thin film transistors. The need of inexpensive or high performance electrode might be even greater for organic photovoltaic (OPV), with the goal to harvest renewable energy with inexpensive, lightweight, and cost competitive materials. The natural abundance of zinc and the wide bandgap (~3.3 eV) of its oxide make it an ideal candidate.
In this dissertation, I have introduced various concepts on the modulations of various surface, interface …