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Physiogenomic Analysis Of Weight Loss Induced By Dietary Carbohydrate Restriction, Gualberto Ruaño, Andreas Windemuth, Mohan Kocherla, Theodore Holford, Maria Luz Fernandez, Cassandra E Forsythe, Richard J Wood, William J Kraemer, Jeff S Volek
Physiogenomic Analysis Of Weight Loss Induced By Dietary Carbohydrate Restriction, Gualberto Ruaño, Andreas Windemuth, Mohan Kocherla, Theodore Holford, Maria Luz Fernandez, Cassandra E Forsythe, Richard J Wood, William J Kraemer, Jeff S Volek
Nutrition Articles
ABSTRACT : BACKGROUND : Diets that restrict carbohydrate (CHO) have proven to be a successful dietary treatment of obesity for many people, but the degree of weight loss varies across individuals. The extent to which genetic factors associate with the magnitude of weight loss induced by CHO restriction is unknown. We examined associations among polymorphisms in candidate genes and weight loss in order to understand the physiological factors influencing body weight responses to CHO restriction. METHODS : We screened for genetic associations with weight loss in 86 healthy adults who were instructed to restrict CHO to a level that induced …
Effects Of A Carbohydrate-Restricted Diet On Emerging Plasma Markers For Cardiovascular Disease, Richard J Wood, Jeff S Volek, Steven R Davis, Carly Dell'ova, Maria Luz Fernandez
Effects Of A Carbohydrate-Restricted Diet On Emerging Plasma Markers For Cardiovascular Disease, Richard J Wood, Jeff S Volek, Steven R Davis, Carly Dell'ova, Maria Luz Fernandez
Nutrition Articles
BACKGROUND : Increasing evidence supports carbohydrate restricted diets (CRD) for weight loss and improvement in traditional markers for cardiovascular disease (CVD); less is known regarding emerging CVD risk factors. We previously reported that a weight loss intervention based on a CRD (% carbohydrate:fat:protein = 13:60:27) led to a mean weight loss of 7.5 kg and a 20% reduction of abdominal fat in 29 overweight men. This group showed reduction in plasma LDL-cholesterol and triglycerides and elevations in HDL-cholesterol as well as reductions in large and medium VLDL particles and increases in LDL particle size. In this study we report on …
Guinea Pigs: A Suitable Animal Model To Study Lipoprotein Metabolism, Atherosclerosis And Inflammation, Maria Luz Fernandez, Jeff S Volek
Guinea Pigs: A Suitable Animal Model To Study Lipoprotein Metabolism, Atherosclerosis And Inflammation, Maria Luz Fernandez, Jeff S Volek
Nutrition Articles
Numerous animal models have been used to study diet effects on cholesterol and lipoprotein metabolism. However, most of those models differ from humans in the plasma distribution of cholesterol and in the processing of lipoproteins in the plasma compartment. Although transgenic or knock-out mice have been used to study a specific pathway involved in cholesterol metabolism, these data are of limited use because other metabolic pathways and responses to interventions may differ from the human condition.Carbohydrate restricted diets have been shown to reduce plasma triglycerides, increase HDL cholesterol and promote the formation of larger, less atherogenic LDL. However, the mechanisms …
Plasma Ldl And Hdl Characteristics And Carotenoid Content Are Positively Influenced By Egg Consumption In An Elderly Population, Christine M Greene, David Waters, Richard M Clark, John H Contois, Maria Luz Fernandez
Plasma Ldl And Hdl Characteristics And Carotenoid Content Are Positively Influenced By Egg Consumption In An Elderly Population, Christine M Greene, David Waters, Richard M Clark, John H Contois, Maria Luz Fernandez
Nutrition Articles
BACKGROUND : Approximately 1/3 of individuals have a high plasma response to dietary cholesterol (hyper-responders). Although increases in both LDL and HDL cholesterol have been observed, limited data exist regarding effects of egg consumption on lipoprotein subclasses and circulating carotenoids. METHODS : 29 postmenopausal women (50-68 y) and 13 men (60-80 y) were assigned to either 3 eggs (EGG, 640 mg cholesterol/d) or an equal volume of cholesterol-free egg substitute (SUB, 0 mg cholesterol/d) for 30 d. Following a 3 wk wash out, subjects crossed over to the alternate diet. Individuals with a response to dietary cholesterol > 2.2 mg/dL for …