Digital Commons Network^™

Evaluating Digital Cognitive Biomarkers As A Noninvasive Diagnostic Tool For Alzheimer's Disease: Correlations With Classic Csf Biomarkers, Kasey Corripio

Honors Undergraduate Theses

Alzheimer's Disease (AD) is a neurodegenerative disorder affecting over 35 million people. Early diagnosis and intervention are crucial for improving outcomes. Digital Cognitive Biomarkers (DCBs) offer a promising approach for early detection and disease management, quantifying cognitive processes of encoding and retrieval through a hierarchical Bayesian cognitive processing model using wordlist memory tests. We hypothesize that DCBs will correlate with classic AD cerebrospinal fluid (CSF) biomarkers (Aβ42, T-tau, p-tau) in patients with varying cognitive decline levels compared to healthy elderly controls. Using Alzheimer's Disease Neuroimaging Initiative (ADNI) data and paired Pearson correlation coefficient analysis, our results support the hypothesis, indicating …

Benefits Of A Family-Based Judo Program For Parents Of Children With Autism Spectrum Disorder, Jeslin George

Honors Undergraduate Theses

A diagnosis of Autism Spectrum Disorder (ASD) can impact the entire family. Parents of children with ASD reportedly have greater stress levels, family conflict, financial concerns, and poor health habits than parents of neurotypical (NT) children. While many parent-focused interventions have been developed, these interventions focus on parent training and child behavior outcomes rather than the health and well-being of the parents. Therefore, this study aimed to examine the effects of a 15-week family judo program on physical and psychosocial health in parents of children with ASD. A total of 18 parents of children with ASD participated in a weekly …

The Relationship Between Evening Screen Time Use And Objectively Measured Sleep Outcomes In U.S. College Students, Donya Sedaghat

Honors Undergraduate Theses

Research suggests that elevated levels of screen time in the evening can negatively impact sleep outcomes (sleep duration, quality, and latency). Yet, there is a lack of evidence exploring if this relationship exists in college students. The purpose of this study is to investigate the relationship between evening screen time use and objectively measured sleep outcomes in US college students. College students (N = 29) junior or senior standing in a Health Sciences major were recruited to participate in this cross-sectional study. Participants wore accelerometers on their wrist for 24hr/day for seven days to capture sleep duration, efficiency, awakenings, and …

The Mental And Dental Repercussions Of Obstructive Sleep Apnea And Its Treatments, Emily E. Mcgoohan

Honors Undergraduate Theses

The purpose of this study is to examine the relationship between dental and mental health. To dive deeper into seeing this connection, patients with sleep apnea will be asked to share their experiences with the treatments for sleep apnea and how it had affected their mental or dental health.

Effect Of Estrogen On Chondrogenesis In Female Articular Chondrocytes, Ebony R. Parsons

Honors Undergraduate Theses

As women age and transition into menopause they face a higher risk of developing osteoarthritis leading to total joint replacements. Estrogen is the primary female reproductive hormone. As a woman approaches menopause, estrogen production decreases by 100-fold. Previous research has shown that Estrogen Replacement Therapy (ERT) reduced joint replacements in post-menopausal women. However, there is a lack of research surrounding ERT's effect on chondrocyte proliferation and extracellular matrix production, particularly 3D culture extracellular matrix production. Chondrogenesis is a process of skeletal development resulting in the formation of cartilage. Chondrocytes, derived from mesenchymal progenitors, serve as the fundamental cellular component in …

Characterization Of Multiphase Complex Coacervate Droplets, Lindsey Rush

Honors Undergraduate Theses

The intracellular environment of eukaryotic cells has been found to have membrane-less organelles, which form through liquid-liquid phase separation.^1,2 The membrane-less organelles within the cell can be modeled with multiphase complex coacervates that are formed through the combination of two liquid polyelectrolyte complex coacervates, which are individually made up of a pair of one positively charged polymer and one negatively charged polymer.^3,4 Membrane-less organelles in a eukaryotic cell have been found to aggregate from liquid to solid in neurological disorders and during the aging process⁵, and investigation into the factors affecting aggregation of multiphase complex coacervates …

Evaluation Of Sleep Benefits Following A 16-Week Judo Program For Children With Autism Spectrum Disorder, Neha R. Chittaluru

Honors Undergraduate Theses

Autism Spectrum Disorder is a neurodevelopmental disorder characterized by language and communication deficits, and difficulties with social interaction (Twisk, 2001). Research has shown that 80% of youth with ASD experience sleep challenges which can lead to sleep-related health issues, exacerbate problematic behaviors, and increase vulnerability to anxiety and depression (Wachob & Lorenzi, 2015; Williams et al., 2004; Richdale & Schreck, 2009). Sleep plays a central role in adaptive functioning, and insufficient sleep can hinder learning, memory, and neuroplasticity for children with ASD (Cohen et al., 2014). As these unhealthy behavior patterns can lead to more adverse long-term health consequences, it …

Nursing-Related Interventions To Obstetric Violence: A Literature Review, Annaliece M. Balensiefen

Honors Undergraduate Theses

The aim of this literature search was to explore the prevalence of obstetric violence and identify nursing interventions that could potentially prevent the mistreatment of pregnant women in the United States healthcare system. Background: The topics of obstetric violence and healthcare disparities have been gaining awareness. Other countries have a larger body of research for obstetric violence compared to the U.S. Methods: CINAHL Plus with Full Text and MEDLINE databases were utilized. Global perspectives were considered in conjunction with the U.S. and specifically Florida. Healthcare disparities in obstetric care were identified, based on race, ethnicity, socioeconomic status, sexuality, disability, …

The Efficacy Of Treatment Of Symptoms Of Polycystic Ovarian Syndrome And Associated Health Risks Using Insulin Sensitizers: A Meta-Analysis, Isabella J. Wong

Honors Undergraduate Theses

Polycystic Ovarian Syndrome (PCOS) is common among women of reproductive age (ages 15-49), and it can put patients at higher risk for diseases such as type II diabetes or coronary heart disease. While the mechanisms behind PCOS are poorly understood, it is diagnosed using two characteristics: hyperandrogenism and anovulation. Once diagnosed, many patients are also tested for insulin resistance (IR). While IR is thought of as a symptom of PCOS, this study will examine the effects of treatment of IR to manage symptoms of PCOS rather than treatment of hyperandrogenism. This meta-analysis used data from studies previously published by searching …

Comparison Of Health-Related Quality Of Life Trajectories In Older Breast Cancer Patients And Noncancerous Controls Over Ten Years, Maria Eduarda De Azevedo Daruge

Honors Undergraduate Theses

The adverse effects of cancer treatment on health-related quality of life (HRQL) are the primary concern of elderly women diagnosed with breast cancer. The interplay of transient and progressive functional impairments caused by cancer therapies, alongside the accelerated physical declines associated with the normal aging process, are all negatively correlated to HRQL. This study compared the HRQL trajectories between cases and controls for ten years after diagnosis. The cancer group included 1467 women (age ≥ 65), diagnosed with primary breast cancer, registered in the Surveillance Epidemiology and End Results (SEER) cancer registry, and completed the Medicare Health Outcomes Survey (MHOS) …

Testicular Cancer And Firefighters: An Umbrella Review, Andre Naguib Guirguis

Honors Undergraduate Theses

Purpose: The relationship between testicular cancer and working as a firefighter has been a relatively brushed off scope of concentration until recent years and recent developments in hopes of presenting new protocols and better guidelines to screen for testicular cancer in this occupation. The purpose of this study was to perform a scoping review to present the current data concerning testicular cancer and its association to the occupation of firefighters.

Methods: PubMed as a data base was used and articles concerning firefighters and testicular cancer were found and screened for eligibility with respect to the kind of study and the …

The Influence Of Genetics, Insulin Resistance, Oxidative Stress, And Energy Deficit On Migraine, Victoria Dm Maldonado Llinas

Honors Undergraduate Theses

The pathomechanism of migraine attacks is not understood well, however, is currently believed to be a brain disorder. Migraine is a multifactorial disorder that needs to be investigated in multiple research areas to shed light into its mechanism and find ways to treat it effectively. Migraine episodes come from one or many things at the same time, and such vary from person to person. However, sufficient evidence in recent studies show there is a strong relationship between genetics with patients having specific genes that may be responsible for the disease or a genetic sequence passed down through generations in families, …

Social Determinants Of Chronic Kidney Disease In The Black American Community: A Systematic Review, Addea Coleman

Honors Undergraduate Theses

This systematic review aims to examine the relationship between the social determinants of health that significantly impact the prevalence and progression of chronic kidney disease (CKD) amongst Black Americans. The Black American population has the highest prevalence of CKD in the United States, while concurrently possessing prominent genetic risk factors for this chronic disease. The social determinants: healthcare quality and access (extended to account for health behaviors), social and community context, and economic stability were specifically assessed in this review. Key terms were utilized to search electronic databases PubMed and Web of Science, which yielded 470 unduplicated articles. Twenty-nine articles …

Utilizing Bloodless Medicine To Decrease Infection Rates In Hematopoietic Stem Cell Transplantation: A Literature Review, Samantha Saint Fort

Honors Undergraduate Theses

Aim: To determine if a significant relationship exists between bloodless medicine practices and decreased infection rates in oncology patients following hematopoietic stem cell transplantation by performing a literature review.

Background: It is not uncommon for healthcare professionals to encounter Jehovah's Witnesses (JW) seeking medical treatment in the acute care hospital setting and outpatient clinics alike. However, JW's pose a unique challenge to healthcare providers. Their refusal of blood transfusions makes them a population of interest within the medical community. The refusal of blood transfusions also poses a serious challenge to successful treatment in oncology JW patients, and many hospitals will …

Targeting L-Arginine Metabolism To Control Small Cell Lung Cancer Transformation, Robert L. Burns Jr.

Honors Undergraduate Theses

Cancer is known for its unregulated and mutagenic characteristics. The topic of targeting cancer by inhibiting the metabolic pathways it uses to thrive has been a focus of modern cancer research. Specifically, in lung cancer, the transformation from non-small cell lung cancer (NSCLC) to small cell lung cancer (SCLC) is a focus. This transformation often comes with a grimmer prognosis and reduced survival rate. This is primarily due to SCLC being resistant to epidermal growth factor receptor (EGFR) inhibitors. This frontline treatment for EGFR mutant NSCLC has shown to be quite effective until transformation to SCLC occurs. To further study …

The Effectiveness Of Therapeutic Interventions For The Management Of Vulvodynia: An Integrated Literature Review, Arianna Cohen

Honors Undergraduate Theses

Problem: Vulvodynia, an unexplained vulvar pain, is a medical condition affecting women of all ages, races, and ethnicities and causes pain levels ranging from very mild discomfort to extreme suffering.

Purpose: The purpose of this study was to explore women’s knowledge toward seeking care for vulvodynia and to explore the different types of treatments prescribed after diagnosis. The secondary purpose of this review was to describe the treatments most effective in reducing pain caused by vulvodynia.

Methods: A review of the literature was conducted using articles from 2001 to 2021 that focused on diagnosis of vulvodynia and the relief of …

Evaluating Non-Pharmaceutical Sleep Hygiene Interventions For The Prevention Of Delirium And Improvement In Sleep Quality In Critical Care, Sonja L. Colby

Honors Undergraduate Theses

Patients admitted to an adult intensive care unit (ICU) are at risk of developing an acute condition known as ICU delirium, which can impact patients’ length of hospital stay and increase short term and 6-month mortality. The cause of ICU delirium is multifactorial, and lack of quality sleep is a known risk factor. Patients’ sleep in the ICU is frequently interrupted by clinicians involved in their care and equipment alarms. Sleep hygiene interventions to minimize these interruptions for the patient are one strategy to reduce the risk of ICU delirium. Examples of sleep hygiene interventions include eye masks, earplugs, and …

Obstetrical Nursing Care And Cesarean Section Delivery Rates In Laboring Women: An Integrative Review Of Literature, Ayana Cornelius

Honors Undergraduate Theses

Background: There is a documented overuse of C-sections (CS) in the United States. The majority of research surrounding CS overuse focuses on the physician’s role, location (state, city, hospital), hospital policies, and the reason why the CS is being performed. Little research focuses on the nurse’s influence on CS outcomes, although nurses spend the longest amount of time with the patient. Methods: Data for this literature review examined 13 research articles between 1992 to present, exploring factors relating to the overuse of CS, specifically, data relating to the correlation between CS and the nurse’s role. Results: Recent research has shown …

The Intertwined Relationship Of Stress And Sleep Quality Of Undergraduate Students During The Covid-19 Pandemic, Jordan Nguyen

Honors Undergraduate Theses

This study aims to examine the relationship between stress and sleep of undergraduate students during the course of the COVID-19 pandemic. The possibly correlational relationship between these two parameters was determined with respect to how this population was faring during recent times, two years into the pandemic. The study also served to examine how this relationship changed over time based on three time frames: before the pandemic, during the advent of the lockdown (March 2020-May 2020), and during recent times. A survey was developed to collect data from the undergraduate participants for correlation and regression analysis to determine the relationship …

Uterine Fibroid Prevalence And Health Care Disparities By County. Florida, 2010-2019, Saarah K. Sherifi

Honors Undergraduate Theses

Also known as uterine fibroids, leiomyomas occur in 70% of women. A uterine leiomyoma is a benign growth in the muscular wall of the uterus which, if left untreated, can grow, and affect surrounding organs, leading to complications, including hemorrhage and death. Symptomatic women often experience pain and debilitating menstrual cycles which, in turn, result in poor health, poor quality of life, and loss of income. Preventative and treatment services in Florida could benefit from the characteristics of women affected the most by this disease in the state. Thus, we describe the demographic characteristics and estimate the prevalence rate of …

The Impact Of Head And Neck Surgical Scars On Appearance And Acceptance Of Dermatography As A Cosmetic Intervention, Simcha Chaitoff

Honors Undergraduate Theses

Many surgical procedures in the head and neck regions produce visible scarring. The most common of these surgeries are tracheotomies and thyroidectomies. The recent COVID-19 pandemic has caused an increase in tracheotomy scars, particularly in those who survived severe infection with the disease and required long-term ventilation. Individuals with neck scars are at an increased risk of health consequences such as reduced quality of life, depression, and negative body image. Research on attitudes toward and reactions to individuals with such scarring is limited. The purpose of this study is to examine how people rate images of scarred individuals on personality …

An Examination Of Lung Cancer Treatment Characteristics On Lung Cancer Patients With Co-Existing Heart Disease, Elias Rhanime

Honors Undergraduate Theses

With the rising rates of heart disease incidents in the United States and the increase in lung cancer deaths as well, many individuals suffer and get their treatments compromised due to these diseases. Especially considering that many lung cancer and heart disease patients are over 70 years of age, treatment options and success rates drop significantly. Due to this, a great concern is raised for patients with co-existing heart disease and lung cancer. This was a case-control study that assessed lung cancer treatment options and success rates for patients with co-existing heart disease. We used research papers that discussed lung …

Analyzing The Relationship Between The Quality Of Life And Race Of Lung Cancer Survivors, Alina S. Wise

Honors Undergraduate Theses

Purpose: The relationship between racial disparities and the health-related quality of life (HRQoL) of lung cancer patients is not well understood. The purpose of this study was to quantify the overall HRQoL of lung cancer patients and compare differences in HRQoL among racial groups in the United States.

Methods: We analyzed data from the Behavioral Risk Factors Surveillance System (BRFSS), a population-based national cross-sectional study conducted by the Centers for Disease Control and Prevention. The BRFSS is conducted annually in all 50 states and collects information on demographics, health behaviors, health-related experiences, health conditions, use of medications, and use of …

Mechanical Understanding And Optimization Of Template Guided Core Needle Biopsy, Isaac Girgis

Honors Undergraduate Theses

Prostate cancer is the second highest cause of cancer related deaths among men. According to the diagnostic pathway for prostate cancer, a prostate biopsy is performed if an individual showed signs of lesions through high prostate-specific antigen (PSA) concentration or suggestive digital rectal exam (DRE) results. The core biopsy mechanism involves inserting a beveled needle into the organ and removing a cylindrical fragment of tissue. Many factors affect the histological quality of the sample, including fragmentation, needle deflection, and needle insertion velocity. If a biopsy core is not clinically viable, an alternative core will need to be taken, resulting in …

Covid-19 And Diabetes, Radhika Desai

Honors Undergraduate Theses

Patients with Type 2 Diabetes (T2D) have been found to have increased mortality and morbidity for COVID-19 and are at higher risk for severe disease once infected with COVID-19. Clearly, there exists a relationship between T2D and COVID-19 that requires more attention. In order to understand the mechanisms by which T2D contributes to more severe COVID-19 disease, attention was turned to extracellular vesicles (EVs). It was speculated that viral RNA components of the COVID-19 virus may have originated from circulating EVs that came from infected cells and use a Trojan Exosome method to infect host cells. It is necessary to …

The Impact Of Endometriosis-Associated Pelvic Pain On The Social And Academic Wellbeing Of Women Enrolled In University, Ava E. Bettencourt

Honors Undergraduate Theses

Background: Endometriosis, a medical condition in which endometrial tissue lining grows outside of the uterus, affects approximately 10-15 percent of women of reproductive age. While research has shown that symptoms of endometriosis negatively affect quality of life in women, few studies have examined the impact of this condition specifically in college students who may be overwhelmed with the stress of school, living independently, and managing the symptoms of their endometriosis. Purpose: To examine the impact of endometriosis on academic and psychosocial factors in university students. Methods: Four college females completed the Pain Self-Efficacy Questionnaire (PSEQ), a 10-item survey used to …

A Meta-Analysis: Significance Of Biofluid Biomarkers In Sports-Related Traumatic Brain Injury, Stephanie Oliveira

Honors Undergraduate Theses

Background: To reduce the reliance on clinical judgment for the regulation of sports-related traumatic brain injury, identifying and measuring objective to biofluid biomarkers can provide important insight into the diagnosis (Determining the type and origin of a disorder) and prognosis (Determining the chance of survival of a disorder) of SR-TBIs. A biomarker is a qualitative or quantitative measurement that provides a measure of a subject’s physiological or pathological condition at a specific time or during a disease state. Recent literature has suggested that biomarkers can help in the screening of patients exhibiting symptoms of mild traumatic brain injury (mTBI). Despite …

Intractable Pediatric Epilepsy And Dietary Therapies: A Meta-Analysis Of Trials For Seizure Reduction, Victor Figueira M Dantas

Honors Undergraduate Theses

Objective: to compare dietary treatments and their effectiveness in reducing seizures through a systematic review and meta-analysis of clinical trials Methods: Using the PRISMA Method, the Primo database was searched to find peer-reviewed articles where researchers compared one treatment against another. The treatments of choice present in all studies are the Ketogenic Diet and the Modified Atkins Diet. Due to the nature of the experiments, the Ketogenic Diet was considered the control, as it was coined first. Results: Of the 450 articles identified, 378 met the primary peer review threshold and 190 were classified as Open Access. Eight met eligibility …

Developing A Self-Sanitizing Mask To Combat The Spread Of Infectious Disease, Matthew Crawford

Honors Undergraduate Theses

Masks have become an important part of everyday life, protecting both the wearer and individuals nearby from the spread of infectious diseases, most notably severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the coronavirus that causes coronavirus disease 2019 (COVID-19). However, these masks are easily contaminated, whether through continued use or by the wearer touching the mask fabric with contaminated hands, therefore reducing the efficacy and exposing the user to these contagions. When the mask becomes contaminated, it can be discarded, which produces large amounts of waste that will end up in a landfill, or it can be washed, which is …

Targeting T Cell Glycolysis To Mitigate Graft-Versus-Host Disease, Kevin Ezhakunnel

Honors Undergraduate Theses

Hematological cancers account for nearly ten percent of cancer cases diagnosed annually in the United States. Patients who fail to respond to chemotherapy or radiotherapy must often undergo a bone marrow transplant to treat their malignancy. A significant complication following this procedure is Graft versus Host Disease (GvHD), which occurs when donor T cells mount an immune response against recipient tissues. Immunological research has highlighted the role of aberrant T cell metabolism, specifically a shift toward aerobic glycolysis, as a key driver behind the occurrence of this condition. The transcription factor FoxK1 has been revealed to be a key regulator …