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Manufacturing The Next Generation Of Vaccines: Non-Egg Based Platform For Influenza Vaccine, Andrew B. Price
Manufacturing The Next Generation Of Vaccines: Non-Egg Based Platform For Influenza Vaccine, Andrew B. Price
Chemical Engineering Undergraduate Honors Theses
This report explores the design of an influenza vaccine manufacturing facility using a non-egg based expression platform. The current standard procedure in flu vaccine production is to grow the virus in bird eggs. However, recently there is evidence that supports production by other expression platforms. The Sf9 insect cell is considered in this report. Facility design including cell culture media formulation through product storage for shipment and final formulation is considered based on the use of an existing facility. The new design also employs the use of disposable equipment such as bioreactors and purification unit operations. These disposables help reduce …
Hollow Fiber Ultrafiltraion And Granulated Activated Carbon Hydrocarbon Removal For Reverse Osmosis Pretreatment, Hayden Dwyer
Hollow Fiber Ultrafiltraion And Granulated Activated Carbon Hydrocarbon Removal For Reverse Osmosis Pretreatment, Hayden Dwyer
Chemical Engineering Undergraduate Honors Theses
Hydraulic Fracturing is becoming an increasing prevalent technology in present society due its ability to produce cheap, clean natural gas as a viable fuel source. One public image draw back to hydraulic fracturing, however, is that it uses large volumes of water. This water returns to surface after stimulation laden with hydrocarbons and other material from down hole. The proposed and test method to treat this flowback water was reverse osmosis membranes with granulated activated carbon and ultrafiltration serving as a pretreatment. This proved to be a very successful method in treating hydraulic fracturing flowback water.
Hydrocarbon Removal, Elizabeth Ashley
Hydrocarbon Removal, Elizabeth Ashley
Chemical Engineering Undergraduate Honors Theses
A group of Chemical Engineers romoved hydrocarbons from a surrogate flowback solution. The solution contained polar and non-polar hydrocarbons that had to be removed to protect an RO membrane. The full scale solution would use UF to remove the non-polar hydrocarbons and GAC beds to remove the soluble hydrocarbons.
Characterization Of An Affitoid Variable Region To Be Used For Mdm-2 Detection In Elisa Microarray, Graham Reinhard
Characterization Of An Affitoid Variable Region To Be Used For Mdm-2 Detection In Elisa Microarray, Graham Reinhard
Chemical Engineering Undergraduate Honors Theses
Sandwich enzyme-linked immunosorbent assay (ELISA) microarray using peptoid-based affinity reagents, referred to as affitoids, is potentially a very powerful tool for the early detection of cancer and other complex diseases. Current detection methods for cancer are inadequate because most are imaging techniques and require that the cancer has progressed far enough for growths to be visible, which is often far too late for treatment to be effective. One possible way to overcome this issue is to use a biological detection technique that is able to detect proteins that are secreted specifically by cancerous cells (referred to as biomarkers). These biomarkers …
Novel Method For Sequential Batch Recovery Of Biomass From A Helical Photobioreactor, Matthew Hurst
Novel Method For Sequential Batch Recovery Of Biomass From A Helical Photobioreactor, Matthew Hurst
Chemical Engineering Undergraduate Honors Theses
This study developed and evaluated a novel method to recover the microalgae species Arthrospira platensis from a closed helical photo bioreactor system. A recovery apparatus was designed and shown to increase recovery by 40% via periodic online recovery runs during exponential growth phase of biomass. Considerations for the apparatus design included the low shear tolerance of the algae and the necessity for a closed system in order to monitor CO2 consumption. The recovery method draws on methods used for large scale recovery as reported in literature by Vonshak and Shimmatsu [1], [2]. This work seeks to improve reactor biomass yield …
The Effect Of The Local Refractive Index On The Spectral Properties Of Gold Nanoparticle Arrays, Justin Norman
The Effect Of The Local Refractive Index On The Spectral Properties Of Gold Nanoparticle Arrays, Justin Norman
Chemical Engineering Undergraduate Honors Theses
Gold nanoparticle arrays exhibit extraordinary spectral properties useful to a wide variety of applications including biomolecular sensing, alternative energy, and informatics. The spectral properties of these arrays depend on the array geometry (particle size and spacing) and the surrounding environment (refractive index). In this thesis, a thorough map of the parameter space describing the spectral properties of square, gold nanoparticle arrays is developed in conjunction with a fundamental theoretical description of the phenomena that govern these properties.
Optimal Production Of Biobutanol Via Hydrogenation Of Butyric Acid, Sarad Panta
Optimal Production Of Biobutanol Via Hydrogenation Of Butyric Acid, Sarad Panta
Chemical Engineering Undergraduate Honors Theses
Butanol is a primary alcohol most commonly used industrially as a solvent. It is largely produced petrochemically using fossil fuel feedstocks. The global butanol market has steadily increased in recent years and is projected to continue increasing at an annual rate of 3.2%. Additionally, the possibility of introducing butanol to the fuel market presents the opportunity to further grow the industry. Because of the increasing demand and its production from fossil fuels, there is a need to manufacture butanol more sustainably and efficiently to help the environment and improve the world economy. Currently, biobutanol is not produced commercially; however, its …
International Environmental Design Contest Task: Hyrdaulic Fracturing Fluid Hydrocarbon Removal As A Reverse Osmosis Pretreatment, Elisabeth Yates
International Environmental Design Contest Task: Hyrdaulic Fracturing Fluid Hydrocarbon Removal As A Reverse Osmosis Pretreatment, Elisabeth Yates
Chemical Engineering Undergraduate Honors Theses
Natural gas is useful in several different applications from chemical feed stock, to energy and fuel source. In the past it has been too expensive to be properly taken advantage of, but in recent years technology advancements have made it a rather cheap commodity. However, these advancements, hydraulic fracturing and horizontal drilling, come at an additional cost. They require massive amounts of water, approximately 7,000,000 gallons per well drilled. After use, this water is laden with salts and dangerous hydrocarbons. In order for the water to be recycled or reused, both components must be removed. Reverse osmosis membranes are commonly …
Protein Isolation Using Peptoid Based Affinity Chromatography, Megan Dunn
Protein Isolation Using Peptoid Based Affinity Chromatography, Megan Dunn
Chemical Engineering Undergraduate Honors Theses
Protein purification is essential for advancements in biotechnology. There are several different methods employed in purifying a particular protein from a complex sample such as a cell lysate. These methods take advantage of differences in the size, charge or binding affinity of the protein. One such method is affinity chromatography which utilizes the binding affinity of a protein toward a certain ligand to purify a protein. This is usually used as a final step to extract the desired protein after the mixture has undergone other purification steps to remove unwanted materials. The goal of this project was to develop a …