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Monitoring Fgf1-Treated Skin Wounds With Label-Free Multiphoton Microscopy, Gianna Busch
Monitoring Fgf1-Treated Skin Wounds With Label-Free Multiphoton Microscopy, Gianna Busch
Biomedical Engineering Undergraduate Honors Theses
Chronic skin wounds pose a significant threat to public health, affecting as many as 5.5 million people in the United States every year and costing the healthcare system $10 billion annually1,2. These wounds are associated with prolonged inflammation, poor vascularization, increased infection risk, and high mortality rates3,4. There is significant interest in developing and testing a variety of biologics to promote wound healing. However, quantitative evaluations of healing are typically limited to measurements of wound size, and there is a critical need to develop quantitative biomarkers sensitive to different aspects of the healing process. Label-free multiphoton …
Optical Metabolic Imaging As A Predictor Of Patient Tumor Response To Therapy And Apoptosis, Andrew Larey
Optical Metabolic Imaging As A Predictor Of Patient Tumor Response To Therapy And Apoptosis, Andrew Larey
Biomedical Engineering Undergraduate Honors Theses
Despite a plethora of medical advancements, malignant tumors remain difficult to treat due to complex cancer biology and interpatient heterogeneity. Phenotypically similar tumors may respond differently to a given treatment. In clinical oncology, it is paramount to quantify tumor response to therapy for predicting treatment outcome, monitoring tumor changes, identifying effective therapies, and avoiding unnecessary cost and toxicity to the patient. Current standards of monitoring tumor response to therapy include CT, MRI, PET, and histopathology; these methods either take a merely anatomical approach or are invasive and time consuming, necessitating a functional biomarker approach. MPM represents a metabolic-level method of …