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Comparing Decellularized Muscle Tissue With An Engineered Muscle Biomaterial, Katelin Cherry
Comparing Decellularized Muscle Tissue With An Engineered Muscle Biomaterial, Katelin Cherry
Biomedical Engineering Undergraduate Honors Theses
Decellularized tissues composed of extracellular matrix are commonly used for tissue transplantations but this method has many limitations. An alternative approach is to create an extracellular matrix by seeding degradable foams with cells, culturing these foams to allow extracellular matrix to be secreted from the cells, then washing away the degradable foam to collect the material that is produced. This study was interested in comparing decellularized skeletal muscle tissue to an engineered biomaterial that was seeded with skeletal muscle myoblast cells. Collagen content of decellularized tissue and engineered biomaterial were quantified using a hydroxyproline assay to compare the two samples. …
Highly Sensitive Method For Detecting And Separating Pathogens Using Paramagnetic Particles And A Micro-Fluidic System, William Ryan
Highly Sensitive Method For Detecting And Separating Pathogens Using Paramagnetic Particles And A Micro-Fluidic System, William Ryan
Biomedical Engineering Undergraduate Honors Theses
Water is one of the most important compounds on Earth. If a water supply is contaminated with a pathogen, it can have devastating results to an individual or a community. This research is directed at constructing an easily reproducible procedure that could increase the sensitivity of detecting and separating bacteria from the current limits of about 100 cells to 10-20 cells per sample with a ultimate goal of a single cell detection. Here, we report a micro-fluidic system to magnetically capture pathogenic bacteria in water followed by rapid impedance detection using Escherichia coli K-12 as a model bacterium. Paramagnetic beads …
In Vivo Efficacy Of Chitosan/Interleukin-12 In Controlling Lung Metastasis In 4t1 Breast Cancer Model, Jimmy Vo
Biomedical Engineering Undergraduate Honors Theses
Cancer immunotherapy has emerged as a leading front in cancer treatment. In contrast to other treatment methods such as radiation and surgery, immunotherapy trains the patient's body to recognize and eliminate tumors, thus preventing reoccurrence of secondary tumors. IL-12 has been shown to display a potent anti-tumor immune response in mice; however, when clinical trials were conducted, it was shown to be toxic and in some cases fatal when administered systemically.1,2 Because of this, local delivery of IL-12 is under investigation. Our lab has shown that when paired with the polymer chitosan, local, intratumoral (i.t.) injections of IL-12 are retained …
Rapid Detection And Quantification Of Mycobacterium Tuberculosis Using Single-Based Extension And Capillary Electrophoresis, Anh Vu
Biomedical Engineering Undergraduate Honors Theses
In 1993, the World Health Organization (WHO) has declared tuberculosis (TB) a global emergency. Since then, more than 30 million lives have been claimed by that world-wide epidemic. In 2011, 8.7 million people “felt ill†because of TB and not all TB cases were reported to clinicians. Therefore, it is important to accurately identify TB patients by developing a diagnostic method that is sensitive, fast, and cost-effective. However, conventional methods have not met those criteria because they either require lengthy procedures or may misdiagnose TB cases. Hence, the automated Xpert MTB/RIF, endorsed by WHO in 2010, was developed and so …