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Joint Intervention In Opposing Pathways, Pi3k/Akt And Tgf-Beta, With Px-866 And Raloxifene, To Alter Gene Expression And Suppress Estrogen Receptor-Positive Breast Cancer Cell Proliferation, Gregory William Peek
Joint Intervention In Opposing Pathways, Pi3k/Akt And Tgf-Beta, With Px-866 And Raloxifene, To Alter Gene Expression And Suppress Estrogen Receptor-Positive Breast Cancer Cell Proliferation, Gregory William Peek
All ETDs from UAB
For each regulatory pathway implementing environmental or internal messages, there is at least one additional pathway to relay a message to override or modify the original message, in the event of new or conflicting input. The opposing pathway may also be an instrument for negative feedback or redundancy as well as for transmission of additional encountered conditions or considerations. Because the multiple disease conditions based on aberrant cell cycle proliferation often require a level of correction independent of opposing feedback, selection of opposing pathways for complementary joint input is a practical approach to cancer and related proliferation-associated diseases. Accordingly, I …
The Use Of An Open-Label Placebo To Treat Cancer-Related Fatigue In Cancer Survivors, Theresa Walker Hoenemeyer
The Use Of An Open-Label Placebo To Treat Cancer-Related Fatigue In Cancer Survivors, Theresa Walker Hoenemeyer
All ETDs from UAB
Background: A placebo is an inert substance (e.g., sugar pill) or procedure (e.g., sham surgery) that should confer no beneficial effects. Nonetheless, typically, 30-50% of those randomized to placebos report significant benefits. New studies indicate that the use of disclosed or open-label placebos reduces self-reported symptoms among patients with irritable bowel syndrome, migraine attacks, and major depression. Methods: The investigator conducted a 7-week pilot study to evaluate the feasibility and effects of an open-labeled administration of placebo pills on patient-reported clinical and psychosocial outcomes among cancer survivors seeking relief from cancer-related fatigue. The specific aims of this study were to: …
Atp6v1c1 Enhances Breast Cancer Growth By Activating V-Atpase Mediated Mtorc1 Signaling And Metastasis By Increasing V-Atpase Activity In Cancer Cells, Matthew J. Mcconnell
Atp6v1c1 Enhances Breast Cancer Growth By Activating V-Atpase Mediated Mtorc1 Signaling And Metastasis By Increasing V-Atpase Activity In Cancer Cells, Matthew J. Mcconnell
All ETDs from UAB
It is known that the vacuolar ATPase has a number of functions related to tumor growth and progression such as involvement in drug resistance, pH regulation, autophagy, and lysosomal acid protease activation, as well as invasion and metastasis. Here we specifically describe the role of ATP6v1c1 in murine and human models of breast cancer. ATP6v1c1 is the dominant isoform of the coordinating subunit (ATP6v1c) involved in the assembly of the vacuolar ATPase complex which plays a key role in cancer growth and progression. We also describe how ATP6v1c1 knockdown impairs tumor nutrient signaling through mTORC1 and tumor cell proliferation, by …