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Immunomodulatory Properties Of A Viral Homolog Of Human Interleukin-10 Expressed By Human Cytomegalovirus During The Latent Phase Of Infection, C Jenkins, W Garcia, M J. Godwin, Juliet V. Spencer, J Lewis Stern, Allison Abendroth, Barry Slobedman
Immunomodulatory Properties Of A Viral Homolog Of Human Interleukin-10 Expressed By Human Cytomegalovirus During The Latent Phase Of Infection, C Jenkins, W Garcia, M J. Godwin, Juliet V. Spencer, J Lewis Stern, Allison Abendroth, Barry Slobedman
Biology Faculty Publications
Human cytomegalovirus (HCMV) establishes a latent infection in hematopoietic cells, from which it can reactivate to cause significant disease in immunocompromised individuals. HCMV expresses a functional homolog of the immunosuppressive cytokine interleukin-10 (termed cmvIL-10), and alternate splicing of the cmvIL-10 transcript results in expression of a latency-associated cmvIL-10 transcript (LAcmvIL-10). To determine whether LAcmvIL-10 encodes immunosuppressive functions, recombinant LAcmvIL-10 protein was generated, and its impact on major histocompatibility complex class II (MHC-II) expression was examined on granulocyte macrophage progenitor cells (GM-Ps) and monocytes. LAcmvIL-10 (and cmvIL-10) downregulated MHC-II on the surfaces of both cell types. This downregulation was associated with …
Methods For Detection Of Matrix Metalloproteinases As Biomarkers In Cardiovascular Disease, Viorica Lopez-Avila, Juliet Spencer
Methods For Detection Of Matrix Metalloproteinases As Biomarkers In Cardiovascular Disease, Viorica Lopez-Avila, Juliet Spencer
Biology Faculty Publications
Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteolytic enzymes that degrade extracellular matrix (ECM) components like collagen, fibronectin, and laminin. While this activity is important for normal development, morphogenesis, and wound healing, deregulation of MMP activity has been implicated in a number of cardiovascular diseases, including congenital heart defects, atherosclerosis, myocardial infarction, and congestive heart failure. MMPs are good potential diagnostic indicators of cardiovascular disease, but current detection methods are time consuming and quite laborious. This review will discuss MMP biology, current methods for detection of MMPs from patient samples, and potential new developments in multiplexed analysis of MMPs.