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Investigating The Mechanism Of Jc Polyomavirus Endocytosis, Conner Robert Lajoie
Investigating The Mechanism Of Jc Polyomavirus Endocytosis, Conner Robert Lajoie
Honors College
The majority of the human population is infected with JC polyomavirus (JCPyV), which establishes an asymptomatic infection in the kidney of healthy individuals. In immunosuppressed individuals, the virus spreads to the brain and attacks glial cells, causing progressive multifocal leukoencephalopathy (PML), a fatal demyelinating disease. With limited treatments available, an improved understanding of the virus-host cell interactions during JCPyV infection is crucial for developing effective PML therapies. JCPyV internalization into host cells requires the serotonin 5- hydroxytryptamine type 2 (5-HT2) receptors. The mechanism by which the 5-HT2Rs mediate viral entry has not yet been characterized, yet it is thought to …