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Cross-Seeding Of Protegin-1 And Amyloid Beta To Inhibit Amyloid Beta Aggregation, Sarah Robinson
Cross-Seeding Of Protegin-1 And Amyloid Beta To Inhibit Amyloid Beta Aggregation, Sarah Robinson
Williams Honors College, Honors Research Projects
Amyloid beta (Aβ) is considered a major component in the progression of degenerative disease like Alzheimer’s disease. In an attempt to cure Alzheimer’s before it has presented, this project proposes a study on the effects of protegrin-1 (PG-1) on the aggregation of Aβ. By cross-seeding to form a PG-1- Aβ heterocomplex, it is believed that aggregation of Aβ on the human brain can be inhibited, thus helping to stop the neurodegeneration caused by Alzheimer’s disease. To complete this project, an initial literature review of previous work done by the graduate student leading the project will be completed. After this, experiments …