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Role Of The Immune System In The Modulation Of The Mmr-Deficient Intestinal Stem Cell Niche, Shepard Conner Dec 2023

Role Of The Immune System In The Modulation Of The Mmr-Deficient Intestinal Stem Cell Niche, Shepard Conner

Dissertations & Theses (Open Access)

Mismatch Repair (MMR) is a crucial DNA repair system to maintain genomic integrity in cells that is integrated by specific genes including MLH1, MSH2, MSH6, and PMS2. These genes play a critical role in repairing errors that occur in base pairing by stabilizing the genetic material. When the MMR system fails to correct those errors, MMR deficiency occurs where monoallelic mutations in the MMR genes result in a condition known as Lynch Syndrome (LS). LS makes up approximately 3% of all colorectal cancer (CRC) and is regarded as a hereditary form of CRC, which progresses from MMR-deficient …


Ms 203 Guide To The Herman Detering History Of Photography And Psychiatry Collection (1844-2003), Herman E. Detering Iii Jan 2023

Ms 203 Guide To The Herman Detering History Of Photography And Psychiatry Collection (1844-2003), Herman E. Detering Iii

Manuscript Finding Aids

This collection reflects the interest Herman E. Detering, III, owner of the Detering Book Gallery, had in photography and psychiatry in the 19th century. A primary focus is on the treatment and study of people experiencing various forms of mental illness. Publications from numerous hospitals, asylums, and other organizations are included. The coverage includes the United States, France, England and other places in Europe. See more at MS 203.