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Antithrombin Population Pharmacokinetics In Pediatric Ventricular Assist Device Patients., Brady S Moffett, Marc Anders, Timothy Humlicek, Marianne Galati, Jun Teruya, Iki Adachi, Sebastian Tume
Antithrombin Population Pharmacokinetics In Pediatric Ventricular Assist Device Patients., Brady S Moffett, Marc Anders, Timothy Humlicek, Marianne Galati, Jun Teruya, Iki Adachi, Sebastian Tume
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OBJECTIVES: Describe the pharmacokinetics of antithrombin in pediatric patients undergoing ventricular assist device therapy and provide dosing recommendations for antithrombin in this population.
DESIGN: A retrospective population pharmacokinetic study was designed.
SETTING: Large tertiary care children's hospital Subject inclusion criteria consisted of less than 19 years old.
PATIENTS: Subjects less than 19 years old undergoing therapy with a HeartWare ventricular assist device (HeartWare, Framingham, MA) or Berlin EXCOR ventricular assist device (Berlin GmbH, Berlin, Germany), who received a dose of antithrombin with a postdose antithrombin activity level from January 1, 2011, to June 30, 2017.
INTERVENTIONS: Population pharmacokinetic analysis and …