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Uplift Of Anatolia, Aral I. Okay, Massimiliano Zattin, Ercan Özcan, Gürsel Sunal
Uplift Of Anatolia, Aral I. Okay, Massimiliano Zattin, Ercan Özcan, Gürsel Sunal
Turkish Journal of Earth Sciences
The Cenozoic history of the Anatolian Plateau is investigated using the distribution of the last Cenozoic marine strata, the ages of Neogene continental sediments and magmatic rocks, and thermochronology. In central and northern Anatolia, the youngest marine sediments are of Middle Eocene age and show that the region has been above the sea level since ca. 41 Ma. The preservation of marine Eocene sequences over large regions and widespread distribution of Neogene continental sediments point to minor erosion or subsidence, except in the Miocene core complexes, and indicate average surface uplift or subsidence rates of less than 0.05 km/Myr since …
Eocene-Oligocene Succession At Kıyıköy (Midye) On The Black Sea Coast In Thrace, Aral I. Okay, Michael D. Simmons, Ercan Özcan, Stephen Starkie, Michael D. Bidgood, Andrew R.C. Kylander-Clark
Eocene-Oligocene Succession At Kıyıköy (Midye) On The Black Sea Coast In Thrace, Aral I. Okay, Michael D. Simmons, Ercan Özcan, Stephen Starkie, Michael D. Bidgood, Andrew R.C. Kylander-Clark
Turkish Journal of Earth Sciences
A belt of Upper Eocene-Lower Oligocene marine sedimentary rocks extends from Kıyıköy on the Black Sea coast to Pınarhisar in the Thrace Basin, suggesting a marine connection between the Black Sea and the Thrace Basin during this period. The Cenozoic succession of this marine corridor was studied in the vicinity of Kıyıköy along two measured stratigraphic sections. The sequence lies unconformably over metamorphic basement rocks and consists of ~75 m of bioclastic limestone and sandstone of the Soğucak Formation, overlain by ~40 m of limestone, marl, mudstone, sandstone, and acidic tuff, which are assigned to the newly defined Servez Formation. …
Geochemistry And Mineralogy Of The Shallow Subsurface Red Sea Coastal Sediments, Rabigh, Saudi Arabia: Provenance And Paleoenvironmental Implications, Rabea Haredy, Ibrahim Mohamed Ghandour
Geochemistry And Mineralogy Of The Shallow Subsurface Red Sea Coastal Sediments, Rabigh, Saudi Arabia: Provenance And Paleoenvironmental Implications, Rabea Haredy, Ibrahim Mohamed Ghandour
Turkish Journal of Earth Sciences
Mineralogical and geochemical characteristics of the shallow subsurface sediments retrieved from a short sediment core (2.05 m long) collected from the tidal flat south of Al-Kharrar Lagoon, Rabigh area, Saudi Arabia, are presented to determine the impact of temporal change of depositional environment and distinguish the principal control(s) on their chemical composition. The sediments are dominantly siliciclastic, consisting of two vertically stacked sedimentary facies: lagoonal (LG) gray silt-rich mud to argillaceous very fine sand at the base and intertidal flat (TF) brown mud and argillaceous very fine-grained sands at the top. The sediments of the two facies are similar in …
Petrology Of The Late Triassic Mafic Volcanic Rocks From The Antalya Complex, Southernturkey: Evidence For Mantle Source Characteristics During The Neotethyan Rifting, Utku Bağci, Tamer Rizaoğlu, Güzi̇de Önal, Osman Parlak
Petrology Of The Late Triassic Mafic Volcanic Rocks From The Antalya Complex, Southernturkey: Evidence For Mantle Source Characteristics During The Neotethyan Rifting, Utku Bağci, Tamer Rizaoğlu, Güzi̇de Önal, Osman Parlak
Turkish Journal of Earth Sciences
The Antalya Complex in southern Turkey comprises a number of autochthonous and allochthonous units that originated from the Southern Neotethys. Late Triassic volcanic rocks are widespread in the Antalya Complex and are important for the onset of the rifting stage of the southern Neotethys. The studied Late Triassic volcanic rocks within the Antalya Complex are exposed in the southern part of Saklıkent (Antalya) region. They are represented by pillow, massive, and columnar-jointed lava flows with volcaniclastic breccias and pelagic limestone intercalations. Spilitic basalts exhibit intersertal, microlithic porphyritic, and ophitic textures and are represented by plagioclase, pyroxene, and olivine. Secondary phases …
Middle Eocene High-K Acidic Volcanism In The Princes' Islands (İstanbul) And Itsgeodynamic Implications, Fati̇h Şen
Middle Eocene High-K Acidic Volcanism In The Princes' Islands (İstanbul) And Itsgeodynamic Implications, Fati̇h Şen
Turkish Journal of Earth Sciences
The rock assemblages of the Princes? Islands, which are located to the south of mainland İstanbul, are regarded as parts of the Lower Paleozoic quartz sandstones, although they were initially considered as volcanic rocks by Swan in 1868. They differ from quartz sandstones by their vesicular texture and are devoid of any stratigraphic layering. Their mineral constituents are plagioclase (30%-35%), feldspar (35%-40%), and quartz (20%-25%), corresponding to rhyolite. The crystallization age of the rhyolites is 45.66 ± 0.84 Ma on the basis of the U-Pb zircon data. They show high-K calc-alkaline affinity. On primitive-normalized spider diagrams, negative anomalies of Ba, …
Epidote - Lawsonite Coexistence In Blueschist-Facies Blockfrom The Tavşanlı Zone - Turkey: Petrological Implications, Mete Çeti̇nkaplan
Epidote - Lawsonite Coexistence In Blueschist-Facies Blockfrom The Tavşanlı Zone - Turkey: Petrological Implications, Mete Çeti̇nkaplan
Turkish Journal of Earth Sciences
Metamorphic evolution of an epidote-lawsonite blueschist sample characterized by the coexistence of lawsonite and epidote from Sivrihisar area (Tavşanlı Zone) was studied herein in terms of petrology and mineral equilibria. Based on the textural evidence and phase composition, 2 prograde stages, defined by assemblage-I and -II, and 1 retrograde stage were recognized. Assemblage-I indicates epidote-blueschist facies conditions (12 ± 1 kbar / 485 ± 10 °C). Assemblage-II is characterized by the coexistence of epidote and lawsonite (17 ± 1 kbar / 515 ± 10 °C) corresponding to the interface of lawsonite blueschist and epidote blueschist facies. Phase diagram calculations and …
Review Of Late Cretaceous Volcanogenic Massive Sulfide Mineralization In The Easternpontides, Ne Turkey, Mustafa Kemal Revan
Review Of Late Cretaceous Volcanogenic Massive Sulfide Mineralization In The Easternpontides, Ne Turkey, Mustafa Kemal Revan
Turkish Journal of Earth Sciences
The production of Cu-Zn from volcanogenic massive sulfide (VMS) deposits in the eastern Pontides began in the early 1900s, with the exploitation of high-grade ores scattered across the district. The district still possesses economically important blind VMS and associated sulfide deposits. Careful descriptive documentation of the typical features of these VMS ores illustrated the geological characteristics that are important in identifying ore localities and can be used to define exploration targets. The eastern Pontide VMS deposits are examples of volcanic-hosted massive sulfide deposits that exhibit many of the characteristics typical of bimodal-felsic-type VMS mineralization. Nearly all known VMS deposits in …
Assessment Of Element Concentrations In Surface Sediment Samples Fromsığacık Bay (Eastern Aegean), Özde Bakak, Fi̇li̇z Küçüksezgi̇n, Fai̇k Erdeni̇z Özel
Assessment Of Element Concentrations In Surface Sediment Samples Fromsığacık Bay (Eastern Aegean), Özde Bakak, Fi̇li̇z Küçüksezgi̇n, Fai̇k Erdeni̇z Özel
Turkish Journal of Earth Sciences
Concentrations of Al, Fe, As, Co, Cr, Cu, Mn, Ni, Pb, Zn, Hg, and organic carbon, and grain size distribution were investigated in the surface sediments of 7 sampling stations in the Sığacık Bay (western Anatolia) in December 2016. At all of the sampling stations, the concentrations of Pb, Ni, Cr, and As were higher than the average shale values. The highest concentrations of Pb, Cu, Zn, As, and Hg were found at stations near Doğanbey Cape. The possible sources of pollution were evaluated using several parameters: the enrichment factor (Ef), contamination factor (Cf), and contamination degree (Cd). The Ef …
Geochemistry, Risk Assessment, And Pb Isotopic Evidence For Sources Of Heavy Metals Instream Sediments Around The Ulukışla Basin, Niğde, Southern Turkey, Abdurrahman Lermi̇, Emmanuel Daanoba Sunkari
Geochemistry, Risk Assessment, And Pb Isotopic Evidence For Sources Of Heavy Metals Instream Sediments Around The Ulukışla Basin, Niğde, Southern Turkey, Abdurrahman Lermi̇, Emmanuel Daanoba Sunkari
Turkish Journal of Earth Sciences
Concentrations of selected elements (Al, Fe, Mn, Mo, As, Cd, Cu, Cr, Ni, Co, Pb, Sb, and Zn) and Pb isotope ratios were determined in 53 sediments from Alihoca, Gümüş, Horoz, and Çakıt streams around the south-central Taurides (Ulukışla Basin), Niğde, which is a known mining province in Turkey. Several pollution and risk assessment indices were used to assess possible heavy metal pollution in the stream sediments and the associated potential ecological risks. Concentrations of As, Cd, Cu, Cr, Ni, Co, Pb, Sb, and Zn were elevated in the streams located near ancient mines, active mines, and slag piles in …
Assessment Of Acid Mine Drainage Formation Using Geochemical And Static Tests In Mutki(Bitlis, Se Turkey) Mineralization Area, Mehmet Ali̇ Gücer, Selçuk Alemdağ, Enver Akaryali
Assessment Of Acid Mine Drainage Formation Using Geochemical And Static Tests In Mutki(Bitlis, Se Turkey) Mineralization Area, Mehmet Ali̇ Gücer, Selçuk Alemdağ, Enver Akaryali
Turkish Journal of Earth Sciences
In this study, geochemical analyses, as well as short-term contact leaching and acid-base accounting tests, were carried out to determine the occurrence of acid mine drainage (AMD) by static tests in the ore stockpile areas at the Mutki Cu-Fe-Cr deposit (Bitlis, SE Turkey). According to the short-term contact leaching tests, the high enrichment in trace element concentrations in ore-bearing samples, especially in potentially toxic metals such as Cr, Cu, Mn, and Zn, were directly related to sulphide and oxide mineralizations. The pH (3.27-4.05) values of water samples, together with the classification of the intracontinental water resources, indicated that the water …
Geochemical, Stable (O, C, And B) And Radiogenic (Sr, Nd, Pb) Isotopic Data From Theeskişehir-Kızılcaören (Nw-Anatolia) And The Malatya-Kuluncak (E-Central Anatolia)F-Ree-Th Deposits, Turkey: Implications For Nature Of Carbonate-Hosted Mineralization, Okay Çi̇men, Loretta Corcoran, Corinne Kuebler, Stefanie Simonetti, Antonio Simonetti
Geochemical, Stable (O, C, And B) And Radiogenic (Sr, Nd, Pb) Isotopic Data From Theeskişehir-Kızılcaören (Nw-Anatolia) And The Malatya-Kuluncak (E-Central Anatolia)F-Ree-Th Deposits, Turkey: Implications For Nature Of Carbonate-Hosted Mineralization, Okay Çi̇men, Loretta Corcoran, Corinne Kuebler, Stefanie Simonetti, Antonio Simonetti
Turkish Journal of Earth Sciences
In Turkey, the largest fluorine (F)-rare earth element (REE)-thorium (Th) deposits are located within the Eskişehir-Kızılcaören (north-western Anatolia) and the Malatya-Kuluncak (east-central Anatolia) regions, and these are associated with Oligocene extensional alkaline volcanic and Late Cretecaous-Early Paleocene postcollisional intrusive rocks, respectively. In the Kızılcaören region, the basement units include the Triassic Karakaya Complex and the Late Cretaceous oceanic units (Neotethyan suture) that are cut and overlain by phonolite and carbonatite intrusions and lava flows. In the Kuluncak region, the plutonic rocks are mainly composed of syenite, quartz syenite, and rare monzonite, and these cut the late-Cretaceous Karapınar limestone, which hosts …
Last Glacial Climate Oscillations And Sudden Environmental Changes Investigated In Stalagmites From Southwest Sulawesi, Western Pacific, Ezgi̇ Ünal İmer, İbrahi̇m Tonguç Uysal, Emma St Pierre, Jian Xin Zhao, James Shulmeister
Last Glacial Climate Oscillations And Sudden Environmental Changes Investigated In Stalagmites From Southwest Sulawesi, Western Pacific, Ezgi̇ Ünal İmer, İbrahi̇m Tonguç Uysal, Emma St Pierre, Jian Xin Zhao, James Shulmeister
Turkish Journal of Earth Sciences
We investigated two stalagmites from the Saripa Cave and Bumi Cave in southern Sulawesi, Indonesia, using high-precision U-series dating and high-resolution trace element and C-O-Sr isotope analysis. The growth record (from 10.4 ± 0.1 ka to 77.4 ± 0.9 ka) of the Saripa Cave stalagmite (SR04-ST3) is fragmented with two major (at the top: 10.4-11.6 ka and middle: 43.8-44.7 ka sections of the stalagmite) and some short (middle and bottom sections) growth phases, interrupted by long-lasting growth hiatuses. Both the timing of the growth phases and the δ18O values for different growth phases are correlated with those of cold/dry (~22 …
Upper Paleocene-Lower Eocene Calcareous Nannofossil Stratigraphy At The Misheiti Section, Central Sinai, Egypt, Atef M. Kasem, Sherwood Wise, Mahmoud Faris, Sherif Farouk, Esam Zahran
Upper Paleocene-Lower Eocene Calcareous Nannofossil Stratigraphy At The Misheiti Section, Central Sinai, Egypt, Atef M. Kasem, Sherwood Wise, Mahmoud Faris, Sherif Farouk, Esam Zahran
Turkish Journal of Earth Sciences
Calcareous nannofossil, δ13C, δ18O, and carbonate content data were used to define and reveal the variations across the latest Paleocene-earliest Eocene interval at the Misheiti Section, Central Sinai, Egypt. The upper part of Tarawan Formation, the Esna Formation, and the lowermost Thebes Formation were included in this study. In this study, the Esna Formation is informally divided into Hanadi/Mahmiya and Abu Had members. Four calcareous nannofossil zones (NP9, NP10, NP11, and NP12) and four subzones (NP9a, NP9b, NP10a, and NP10b) were recognized. The biostratigraphic importance of significant calcareous nannofossil bioevents associated with the P/E boundary was discussed. The LOs of …
Alluvial-Lacustrine Sedimentation And Volcaniclastic Deposition In An Intracontinental Tectonic Graben: Paleoenvironmental Evolution Of The Neogene Sinanpaşa Basin, West-Central Turkey, Eli̇f Akiska, Baki̇ Erdoğan Varol
Alluvial-Lacustrine Sedimentation And Volcaniclastic Deposition In An Intracontinental Tectonic Graben: Paleoenvironmental Evolution Of The Neogene Sinanpaşa Basin, West-Central Turkey, Eli̇f Akiska, Baki̇ Erdoğan Varol
Turkish Journal of Earth Sciences
This study reports on the Sinanpaşa Basin, a typical example of the Miocene tectonic intracontinental grabens formed in West Anatolia, Turkey. The study reconstructs the paleoenvironmental and paleogeographic history of the graben based on a detailed sedimentological analysis of basin-fill deposits exposed mainly near the graben's northern and southern margins. The sedimentary paleoenvironments in the graben range from basin-margin alluvial fan systems and basin-axis fluvial distributary system to an intrabasinal shallow lake environment surrounded by peat-forming mires, changing from carbonate to more clayey, episodically evaporitic, and shifting its shorelines considerably. The spatial distribution and stratigraphic stacking of these paleoenvironments indicate …
Traces Of Mediterranean Origin Holocene Transgression In The Drainage Basin Of Riva-Çayağzı Creek Of The Black Sea (Northeastern İstanbul-Turkey), Bülent Doğan, Ahmet Karakaş, Ati̇ke Nazi̇k, İbrahi̇m Engi̇n Meri̇ç
Traces Of Mediterranean Origin Holocene Transgression In The Drainage Basin Of Riva-Çayağzı Creek Of The Black Sea (Northeastern İstanbul-Turkey), Bülent Doğan, Ahmet Karakaş, Ati̇ke Nazi̇k, İbrahi̇m Engi̇n Meri̇ç
Turkish Journal of Earth Sciences
The Riva-Çayağzı Creek (İstanbul, Black Sea) pours into the Black Sea from the coasts of Turkey. In the drainage basin of this creek, both deep and shallow drillings were undertaken, and the minimum thickness of Holocene stratigraphy was determined as 30 m. The Holocene young deposits are mainly composed of fine-grained sediments and clay, which has the most prominent thickness. The energy of water during the sedimentation process was low and stagnant in the Riva-Çayağzı Creek basin. When the marine mollusc fossils obtained from the shallow boring cores are evaluated, it can be deduced that the sea level in the …
Geochemical And Industrial Properties Of The Kejal Kaolin Deposit, Nw Iran, Tohid Nouri, Rahim Masoumi
Geochemical And Industrial Properties Of The Kejal Kaolin Deposit, Nw Iran, Tohid Nouri, Rahim Masoumi
Turkish Journal of Earth Sciences
The Kejal kaolin deposit, situated in the northwest of Iran, is considered a small part of the Hashtjin hydrothermal zone. The kaolinization process in this deposit has occurred in ignimbritic and volcanic tuff parent rocks in different grades such that severely kaolinized samples can be found in the middle section of the kaolinization profile. Kaolinite is the most abundant clay mineral in the studied samples. Quartz and cristobalite are the main minerals while anatase is the minor mineral of the kaolin samples. Among the major oxides, SiO2, Al2O3, and TiO2 show the highest concentrations in kaolin samples. The mass change …
Geochemistry And Petrography Of Beach Sands Along The Western Coast Of Ghana:Implications For Provenance And Tectonic Settings, Mahamuda Abu, Emmanuel Daanoba Sunkari
Geochemistry And Petrography Of Beach Sands Along The Western Coast Of Ghana:Implications For Provenance And Tectonic Settings, Mahamuda Abu, Emmanuel Daanoba Sunkari
Turkish Journal of Earth Sciences
The paleoweathering, provenance, and tectonic setting of sediments of the western coast of Ghana were unraveled using the geochemistry of 29 beach sands, which are characterized by coarse-, medium-, and fine-grained sizes. The coarse-grained beach sands contain higher SiO2 content (2.9-96 wt.%) than the medium-grained (4.9-94 wt.%) and fine-grained (16.1-90.7 wt.%) sands, implying that the increase in grain size is related to the increase in SiO2 content. Al2O3 and CaO concentrations are higher in the fine- and medium-grained sands than the coarse-grained sands. The beach sands are compositionally immature based on the index of compositional variable values (1.17-141) and Th/Sc …
Excess Lifetime Cancer Risk Due To Natural Radioactivity In Gümüşhane Province, Ne Turkey, Nafiz Maden, Enver Akaryali, Mehmet Ali̇ Gücer
Excess Lifetime Cancer Risk Due To Natural Radioactivity In Gümüşhane Province, Ne Turkey, Nafiz Maden, Enver Akaryali, Mehmet Ali̇ Gücer
Turkish Journal of Earth Sciences
In this study, 162 in situ measurements of 238U, 232Th, and 40K radionuclide concentrations dataset taken by the gamma-ray spectrometer in Gümüşhane, Turkey are presented. The gamma ray measurements were performed by a 512-channel, three-window gamma-ray spectrometry equipment made by GF Instruments. We first observed the radionuclides of the 238U, 232Th, and 40K values in Gümüşhane. We then calculated the hazard indices of gamma radiation such as annual effective dose equivalent (AEDE), internal and external hazard index (Hin, Hex), and excess lifetime cancer risk (ELCR) based on the radionuclide abundances of 238U, 232Th, and 40K for the first time. In …
E-Cadherin Might Be A Stage-Dependent Modulator In Aggressiveness In Pancreatic Cancer Cells, Esra Aydemi̇r Çoban, Di̇dem Teci̇mel, Ezgi̇ Kaşikci, Ömer Faruk Bayrak, Fi̇kretti̇n Şahi̇n
E-Cadherin Might Be A Stage-Dependent Modulator In Aggressiveness In Pancreatic Cancer Cells, Esra Aydemi̇r Çoban, Di̇dem Teci̇mel, Ezgi̇ Kaşikci, Ömer Faruk Bayrak, Fi̇kretti̇n Şahi̇n
Turkish Journal of Biology
Pancreatic ductal adenocarcinoma (PDAC) pathology is known for its uncontrollable progress due to highly invasive characteristics and refractory behavior against existing chemotherapies. The aberrant expression of CDH1 (expresses the protein E-cadherin) is associated with increased overall survival in various cancers, however, E-cadherin expression in PDAC progression has remained elusive. We investigated the impact of exogenously elevated E-cadherin levels on the tumorigenicity of transduced low grade and metastatic PDAC cell lines, Panc-1 and AsPC-1, respectively. Constitutive expression of E-cadherin promoted a more hybrid E/M state in AsPC-1 cells, while it was associated with the acquisition of a more epithelial-like state in …
Comparison Of Anticarcinogenic Properties Of Viburnum Opulus And Its Active Compound P-Coumaric Acid On Human Colorectal Carcinoma, Serdar Karakurt, Gülsüm Abuşoğlu, Zeki̇ye Ceren Arituluk
Comparison Of Anticarcinogenic Properties Of Viburnum Opulus And Its Active Compound P-Coumaric Acid On Human Colorectal Carcinoma, Serdar Karakurt, Gülsüm Abuşoğlu, Zeki̇ye Ceren Arituluk
Turkish Journal of Biology
Resistance to therapeutic agents and the highly toxic side effects of synthetic drugs has spurred new research in the treatment of colon cancer, which has high morbidity and mortality ratios. This study aims to clarify the molecular mechanisms of the anticarcinogenic properties of methanol extract of Viburnum opulus L. (EVO)and its main active compound, trans-p-coumaric acid (p-CA), on human colon cancer cells (DLD-1, HT-29, SW-620, Caco-2) and healthy colon epithelial cells (CCD-18Co). The effects of EVO on controlled cell death (apoptosis) and the cell division cycle were determined by flow cytometry. Alteration in mRNA and protein expressions of switch genes …
Caffeic Acid Phenethyl Ester Induces Apoptosis In Colorectal Cancer Cells Via Inhibition Of Survivin, Ceren Sari, Ceren Sümer, Fi̇gen Celep Eyüpoğlu
Caffeic Acid Phenethyl Ester Induces Apoptosis In Colorectal Cancer Cells Via Inhibition Of Survivin, Ceren Sari, Ceren Sümer, Fi̇gen Celep Eyüpoğlu
Turkish Journal of Biology
Colorectal cancer is one of the most common types of cancer. Drug resistance and drug-induced damage of healthy tissues are major obstacles in cancer treatment. Therefore, to develop efficient anticancer therapy, it is necessary to find compounds that affect tumor cells, but do not exhibit toxicity to healthy cells. Caffeic acid phenethyl ester (CAPE) has been demonstrated to have anticancer properties in many types of cancer. In this study, the cytotoxic and apoptotic effects of CAPE on the RKO colorectal cancer cell line and CCD 841-CoN normal colorectal cell line was investigated. In addition, changes in the survivin expression were …
Anxiolytic, Antioxidant, And Neuroprotective Effects Of Goji Berry Polysaccharides In Ovariectomized Rats: Experimental Evidence From Behavioral, Biochemical, And Immunohistochemical Analyses, Fatma Pehli̇van Karakaş, Hami̇t Coşkun, Hayri̇ye Soytürk, Bi̇hter Gökçe Bozat
Anxiolytic, Antioxidant, And Neuroprotective Effects Of Goji Berry Polysaccharides In Ovariectomized Rats: Experimental Evidence From Behavioral, Biochemical, And Immunohistochemical Analyses, Fatma Pehli̇van Karakaş, Hami̇t Coşkun, Hayri̇ye Soytürk, Bi̇hter Gökçe Bozat
Turkish Journal of Biology
Recent studies have indicated that polysaccharides, the main component of the Lycium barbarum L. fruit, have beneficial effects (e.g., anxiolytic, antioxidant, and neuroprotective) on humans and rodents. However, the effects of different dosages of such polysaccharides on ovariectomized rats and their underlying mechanisms in the brain have not been evaluated in the literature. Here, we aimed to evaluate the effects of the high and low doses of polysaccharides obtained from Lycium barbarum fruits (HD-LBP and LD-LBP, respectively) on anxious behaviors via behavioral (using the OFT and EPM), biochemical (using ELISA), and immunohistochemical (using immunohistochemical staining) measures in detail. Two weeks …
Upregulation Of Psmd4 Gene By Hypoxia In Prostate Cancer Cells, Sümeyye Aydogan Türkoğlu, Gi̇zem Dayi, Feray Köçkar
Upregulation Of Psmd4 Gene By Hypoxia In Prostate Cancer Cells, Sümeyye Aydogan Türkoğlu, Gi̇zem Dayi, Feray Köçkar
Turkish Journal of Biology
Ubiquitin-proteasome pathways have a crucial role in tumor progression. PSMD4 (Rpn10, 26S proteasome non-ATPase subunit 4), which is a subunit of the regulatory particle, is a major ubiquitin (Ub) receptor of 26S proteasome. PSMD4 overexpression has been observed in colon carcinoma, hepatocellular carcinoma, and breast cancer. In this work, we elucidated the effect of hypoxia on PSMD4 gene expression in prostate cancer cells (PC3). Chemically mimicked hypoxia drastically upregulated PSMD4 gene expression at both mRNA and protein levels. Transient transfection experiments indicated that all promoter fragments were active in PC3 cells. Hypoxia increased transcriptional activity of all PSMD4 promoter constructs. …
Single Nucleotide Polymorphisms In Micrornas Action As Biomarkers For Breast Cancer, Thanh Thi Ngoc Nguyen, Minh Thi Hong Tran, Vy Thi Lan Nguyen, Uyen Doan Phuong Nguyen, Giang Dien Thanh Nguyen, Luan Huu Huynh, Hue Thi Nguyen
Single Nucleotide Polymorphisms In Micrornas Action As Biomarkers For Breast Cancer, Thanh Thi Ngoc Nguyen, Minh Thi Hong Tran, Vy Thi Lan Nguyen, Uyen Doan Phuong Nguyen, Giang Dien Thanh Nguyen, Luan Huu Huynh, Hue Thi Nguyen
Turkish Journal of Biology
MicroRNAs (miRNAs) have been recently described as small noncoding RNAs that are involved in numerous crucial physiological processes, such as cell cycles, differentiation, development, and metabolism. Thus, dysregulation of these molecules could lead to several severe disorders, including breast cancer (BC). Ongoing investigations in malignant growth diagnostics have distinguished miRNAs as promising disease biomarkers. As with any other mRNAs, single nucleotide polymorphisms (SNPs) in DNA sequence encoding for miRNA (miR-SNPs) indeed lead to potential changes in the function of miRNA. In this study, miR-SNPs located in different miRNA sequence regions, which have been associated with BC in different ways, and …
Regulation Of E2f1 Activity Via Pka-Mediated Phosphorylations, Mustafa Gökhan Ertosun, Sayra Di̇lmaç, Fatma Zehra Hapi̇l Zevkli̇ler, Gamze Tanriöver, Sadi̇ Köksoy, Osman Ni̇dai̇ Özeş
Regulation Of E2f1 Activity Via Pka-Mediated Phosphorylations, Mustafa Gökhan Ertosun, Sayra Di̇lmaç, Fatma Zehra Hapi̇l Zevkli̇ler, Gamze Tanriöver, Sadi̇ Köksoy, Osman Ni̇dai̇ Özeş
Turkish Journal of Biology
No abstract provided.