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Evaluation Of The Pathogenicity Of Candida Zeylanoides In Balb/C Mice, Alireza Khosravi, Hojjatollah Shokri, Donya Nikaein, Ahmad Erfanmanesh, Mahnaz Fatahinia, Jalal Ashrafi Hlan
Evaluation Of The Pathogenicity Of Candida Zeylanoides In Balb/C Mice, Alireza Khosravi, Hojjatollah Shokri, Donya Nikaein, Ahmad Erfanmanesh, Mahnaz Fatahinia, Jalal Ashrafi Hlan
Turkish Journal of Veterinary & Animal Sciences
Systemic candidiasis is an opportunistic infection caused by Candida species in animals. The purpose of this study was to evaluate the pathogenicity of different doses of Candida zeylanoides in BALB/c mice. Thirty mice were selected in this study. Different doses of the yeast were intravenously inoculated to the animals. At first, clinical signs and survival time of infected mice were recorded. Then both mycological and histological examinations were performed for detection of Candida in different tissues. The results showed that the injection of 1 × 10^8 cells of C. zeylanoides caused high mortality (group 1). The mortalities occurred within 7-12 …
Alfacalcidol Suppresses Α-Receptor–Mediated Vasoconstriction Via An Endothelium Dependent Mechanism, İsmai̇l Ün, Aki̇f Hakan Kurt, Ali̇ Batuş, Kansu Büyükafşar
Alfacalcidol Suppresses Α-Receptor–Mediated Vasoconstriction Via An Endothelium Dependent Mechanism, İsmai̇l Ün, Aki̇f Hakan Kurt, Ali̇ Batuş, Kansu Büyükafşar
Turkish Journal of Medical Sciences
Vitamin D level could be related to blood pressure and cardiovascular health. However, the direct suppressor effect of vitamin D on vascular contraction has not yet been explored. Therefore, the effects of alfacalcidol (1\alpha-hydroxyvitamin D_3) and calcitriol (1\alpha,25-dihydroxyvitamin D_3) on contractions induced by phenylephrine (10^{-8} to 10^{-5} M) in mice aorta were investigated. Materials and methods: Arterial rings were suspended in isolated organ chambers filled with Krebs bicarbonate solution gassed with 95% O_2 and 5% CO_2 maintained at 37 °C. Tissue responses were recorded isometrically with a force transducer and displayed on an acquisition system. Alfacalcidol and calcitriol were applied …