Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 2 of 2
Full-Text Articles in Entire DC Network
Tbx2 Represses Pten In Rhabdomyosarcoma And Skeletal Muscle., B Zhu, M Zhang, E M Williams, C Keller, A Mansoor, J K Davie
Tbx2 Represses Pten In Rhabdomyosarcoma And Skeletal Muscle., B Zhu, M Zhang, E M Williams, C Keller, A Mansoor, J K Davie
Articles
Rhabdomyosarcoma (RMS) is the most frequent soft tissue sarcoma in children that shares many features of developing skeletal muscle. TBX2, a T-box family member, is highly upregulated in tumor cells of both major RMS subtypes where it functions as an oncogene. TBX2 is a repressor that is often overexpressed in cancer cells and functions in bypassing cell growth control, including the repression of the cell cycle regulators p14 and p21. We have found that TBX2 directly represses the tumor-suppressor phosphatase and tensin homolog (PTEN) in both RMS and normal muscle. Exogenous expression of TBX2 in normal muscle cells downregulates PTEN, …
Alternative Splicing Of Mef2c Pre-Mrna Controls Its Activity In Normal Myogenesis And Promotes Tumorigenicity In Rhabdomyosarcoma Cells., Meiling Zhang, Bo Zhu, Judith Davie
Alternative Splicing Of Mef2c Pre-Mrna Controls Its Activity In Normal Myogenesis And Promotes Tumorigenicity In Rhabdomyosarcoma Cells., Meiling Zhang, Bo Zhu, Judith Davie
Articles
Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children. Many cellular disruptions contribute to the progression of this pediatric cancer, including aberrant alternative splicing. The MEF2 family of transcription factors regulates many developmental programs, including myogenesis. MEF2 gene transcripts are subject to alternate splicing to generate protein isoforms with divergent functions. We found that MEF2Cα1 was the ubiquitously expressed isoform that exhibited no myogenic activity and that MEF2Cα2, the muscle-specific MEF2C isoform, was required for efficient differentiation. We showed that exon α in MEF2C was aberrantly alternatively spliced in RMS cells, with the ratio of α2/α1 highly down-regulated …