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Southern Illinois University Carbondale
Aging; Brain; Cognition; Glutamate; Inflammation; Insulin-like growth factor
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Inflammatory And Glutamatergic Homeostasis Are Involved In Successful Aging, Erin R. Hascup, Feiya Wang, John J. Kopchick, Andrzej Bartke
Inflammatory And Glutamatergic Homeostasis Are Involved In Successful Aging, Erin R. Hascup, Feiya Wang, John J. Kopchick, Andrzej Bartke
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Whole body studies using long-lived growth hormone receptor gene disrupted or knock out (GHR-KO) mice report global GH resistance, increased insulin sensitivity, reduced insulin-like growth factor 1 (IGF-1), and cognitive retention in old-age, however, little is known about the neurobiological status of these mice. The aim of this study was to determine if glutamatergic and inflammatory markers that are altered in aging and/or age-related diseases and disorders, are preserved in mice that experience increased healthspan. We examined messenger ribonucleic acid (mRNA) expression levels in the brain of 4- to 6-, 8- to 10-, and 20- to 22-month GHR-KO and normal …