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Gstm1, Gstt1 And Cyp1a1 Polymorphisms And Risk Of Oral Cancer: A Case-Control Study In Jakarta, Indonesia, Amtha R., Ching C. S., Rosnah Binti Zain, Razak I. A., Basuki B., Roeslan B. O., Gautama W., Purwanto D.
Gstm1, Gstt1 And Cyp1a1 Polymorphisms And Risk Of Oral Cancer: A Case-Control Study In Jakarta, Indonesia, Amtha R., Ching C. S., Rosnah Binti Zain, Razak I. A., Basuki B., Roeslan B. O., Gautama W., Purwanto D.
Prof. Dr. Rosnah Binti Zain
Purpose: to investigate genetic polymorphisms in GSTM1, GSTT1 and CYP1A1 and the association with the risk of oral cancer in the Jakarta population. Method: A total of 81 cases and 162 controls matched for age and sex were selected from 5 hospitals in Jakarta. Sociodemographic data using questionnaires were obtained and peripheral blood samples were collected with informed consent for PCR-RFLP assay. Conditional logistic regression analysis was performed to obtain the association between the risk of oral cancer and GSTM1, GSTT1 and CYP1A1 polymorphisms. Results: GSTM1 and GSTT1 null were slightly overrepresented among cases (60.5% and 45.7% respectively) compared to …