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Metastatic Tumor Evolution In Di#3;Use Gastric Cancer And Cancer Organoid Modeling Implicate Tgfbr2 As A Potential Driver, Patrick Flaherty
Metastatic Tumor Evolution In Di#3;Use Gastric Cancer And Cancer Organoid Modeling Implicate Tgfbr2 As A Potential Driver, Patrick Flaherty
Patrick Flaherty
Probiotics: Finding The Right Regulatory Balance, Diane E. Hoffmann, Claire M. Fraser-Liggett, Frank B. Palumbo, Jacques Ravel, Karen H. Rothenberg, Virginia Rowthorn
Probiotics: Finding The Right Regulatory Balance, Diane E. Hoffmann, Claire M. Fraser-Liggett, Frank B. Palumbo, Jacques Ravel, Karen H. Rothenberg, Virginia Rowthorn
Karen H. Rothenberg
Some products marketed as drugs should be excused from Phase I trials, but safety and efficacy claims for dietary supplements should be more tightly regulated.
Separate Sex-Influenced And Genetic Components In Spontaneously Hypertensive Rat Hypertension, Monte E. Turner, Mark L. Johnson, Daniel Ely
Separate Sex-Influenced And Genetic Components In Spontaneously Hypertensive Rat Hypertension, Monte E. Turner, Mark L. Johnson, Daniel Ely
Monte E. Turner
Previous results from our laboratory indicated two major genetic components of spontaneously hypertensive rat (SHR) hypertension, an autosomal component and a Y chromosome component. Two new substrains, SHR/a and SHR/y, were developed using a series of backcrosses to isolate each of these components. The SHR/a substrain has the autosomal loci and X chromosome from the SHR strain and the Y chromosome from the Wistar-Kyoto (WKY) rat strain. The SHR/y substrain has only the Y chromosome from the SHR and autosomal loci and X chromosome from the WKY strain. Throughout these breeding programs parents were chosen at random without selection for …
Genetic-Divergence Between The Wistar-Kyoto Rat And The Spontaneously Hypertensive Rat, Mark L. Johnson, Daniel Ely, Monte E. Turner
Genetic-Divergence Between The Wistar-Kyoto Rat And The Spontaneously Hypertensive Rat, Mark L. Johnson, Daniel Ely, Monte E. Turner
Monte E. Turner
A method of restriction fragment length polymorphism (RFLP) analysis was used to estimate the amount of genetic divergence between the spontaneously hypertensive rat (SHR) strain and the Wistar-Kyoto (WKY) strain. DNA from each strain was digested with eight restriction endonucleases and hybridized with six single copy gene sequences. The number of hybridization bands in each digestion was used to estimate the total number of bases analyzed and RFLPs were scored as single mutations. Divergence was then estimated by dividing the number of mutations by the number of bases analyzed. In a total of 808 bases analyzed in WKY rats, a …
Testosterone Effects On Renal Norepinephrine Content And Release In Rats With Different Y Chromosomes, Thomas J. Jones, Gail Dunphy, Amy Milsted, Daniel Ely
Testosterone Effects On Renal Norepinephrine Content And Release In Rats With Different Y Chromosomes, Thomas J. Jones, Gail Dunphy, Amy Milsted, Daniel Ely
Amy Milsted
The Y chromosome in spontaneously hypertensive rats (SHR) and stroke-prone rats has been shown to contain a locus that contributes to the hypertensive effect; both the sympathetic nervous system and testosterone may be involved. The objective of this study was to look at the effects of testosterone on renal norepinephrine (NE) release and content in the isolated perfused kidney in different Y chromosome backgrounds. The study involved male SHR, Wistar-Kyoto rats (WKY), and 2 consomic strains with different Y chromosomes (n=5 to 8 per group). Adult animals were castrated, and implants containing testosterone propionate were placed at the base of …