Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 6 of 6
Full-Text Articles in Entire DC Network
Association Of Late-Onset Alzheimer's Disease With Genetic Variation In Multiple Members Of The Gapd Gene Family, Yonghong Li, Petra Nowotny, Peter Holmans, Scott Smemo, John S. K. Kauwe, Anthony L. Hinrichs, Kristina Tacey, Lisa Doil, Ryan Van Luchene, Veronica Garcia, Charles Rowland, Steven J. Schrodi, Diane Leong, Goran Gogic, Joanne Chan, Anibal Cravchik, David Ross, Kit Lau, Shirley Kwok, Sheng-Yung Chang, Joe Catanese, John Sninsky, Thomas J. White, John Hardy, John Powell, Simon Lovestone, John C. Morris, Leon Thal, Michael Owen, Julie Williams, Alison Goate, Andrew Grupe
Association Of Late-Onset Alzheimer's Disease With Genetic Variation In Multiple Members Of The Gapd Gene Family, Yonghong Li, Petra Nowotny, Peter Holmans, Scott Smemo, John S. K. Kauwe, Anthony L. Hinrichs, Kristina Tacey, Lisa Doil, Ryan Van Luchene, Veronica Garcia, Charles Rowland, Steven J. Schrodi, Diane Leong, Goran Gogic, Joanne Chan, Anibal Cravchik, David Ross, Kit Lau, Shirley Kwok, Sheng-Yung Chang, Joe Catanese, John Sninsky, Thomas J. White, John Hardy, John Powell, Simon Lovestone, John C. Morris, Leon Thal, Michael Owen, Julie Williams, Alison Goate, Andrew Grupe
Steven J Schrodi
Although several genes have been implicated in the development of the early-onset autosomal dominant form of Alzheimer's disease (AD), the genetics of late-onset AD (LOAD) is complex. Loci on several chromosomes have been linked to the disease, but so far only the apolipoprotein E gene has been consistently shown to be a risk factor. We have performed a large-scale single-nucleotide polymorphism (SNP)-based association study, across the region of linkage on chromosome 12, in multiple case-control series totaling 1,089 LOAD patients and 1,196 control subjects and report association with SNPs in the glyceraldehyde-3-phosphate dehydrogenase (GAPD) gene. Subsequent analysis of GAPD paralogs …
Selecting Tagging Snps For Association Studies Using Power Calculations From Genotype Data, Xiaolan Hu, Steven J. Schrodi, David A. Ross, Michele Cargill
Selecting Tagging Snps For Association Studies Using Power Calculations From Genotype Data, Xiaolan Hu, Steven J. Schrodi, David A. Ross, Michele Cargill
Steven J Schrodi
Recent studies have indicated that linkage disequilibrium (LD) between single nucleotide polymorphism (SNP) markers can be used to derive a reduced set of tagging SNPs (tSNPs) for genetic association studies. Previous strategies for identifying tSNPs have focused on LD measures or haplotype diversity, but the statistical power to detect disease-associated variants using tSNPs in genetic studies has not been fully characterized. We propose a new approach of selecting tSNPs based on determining the set of SNPs with the highest power to detect association. Two-locus genotype frequencies are used in the power calculations. To show utility, we applied this power method …
Association Of Abca1 With Late-Onset Alzheimer's Disease Is Not Observed In A Case-Control Study, Steven J. Schrodi
Association Of Abca1 With Late-Onset Alzheimer's Disease Is Not Observed In A Case-Control Study, Steven J. Schrodi
Steven J Schrodi
Genetic association of ABCA1 or the ATP-binding cassette A1 transporter with late-onset Alzheimer’s disease (LOAD) has recently been proposed for a haplotype comprised of three single nucleotide polymorphisms (SNPs). We have genotyped these and other ABCA1 SNPs in a LOAD case-control series of 796 individuals (419 cases versus 377 controls) collected at Washington University. While our sample series is larger and thus presumably has greater power than any of the series used to implicate ABCA1, we were unable to replicate the published association, using either single markers or multiple marker haplotypes. Further, we did not observe significant and replicated association …
A Missense Single-Nucleotide Polymorphism In A Gene Encoding A Protein Tyrosine Phosphatase (Ptpn22) Is Associated With Rheumatoid Arthritis, Ann B. Begovich, Victoria E. H. Carlton, Lee A. Honigberg, Steven J. Schrodi, Anand P. Chokkalingam, Heather C. Alexander, Kirstin G. Ardlie, Qiqing Huang, Ashley M. Smith, Jill M. Spoerke, Marion T. Conn, Monica Chang, Sheng-Yung P. Chang, Randall K. Saiki, Joseph J. Catanese, Diane U. Leong, Veronica E. Garcia, Linda B. Mcallister, Douglas A. Jeffery, Annette T. Lee, Franak Batliwalla, Elaine Remmers, Lindsey A. Criswell, Michael F. Seldin, Daniel L. Kastner, Christopher I. Amos, John J. Sninsky, Peter K. Gregersen
A Missense Single-Nucleotide Polymorphism In A Gene Encoding A Protein Tyrosine Phosphatase (Ptpn22) Is Associated With Rheumatoid Arthritis, Ann B. Begovich, Victoria E. H. Carlton, Lee A. Honigberg, Steven J. Schrodi, Anand P. Chokkalingam, Heather C. Alexander, Kirstin G. Ardlie, Qiqing Huang, Ashley M. Smith, Jill M. Spoerke, Marion T. Conn, Monica Chang, Sheng-Yung P. Chang, Randall K. Saiki, Joseph J. Catanese, Diane U. Leong, Veronica E. Garcia, Linda B. Mcallister, Douglas A. Jeffery, Annette T. Lee, Franak Batliwalla, Elaine Remmers, Lindsey A. Criswell, Michael F. Seldin, Daniel L. Kastner, Christopher I. Amos, John J. Sninsky, Peter K. Gregersen
Steven J Schrodi
Rheumatoid arthritis (RA) is the most common systemic autoimmune disease, affecting approximately 1% of the adult population worldwide, with an estimated heritability of 60%. To identify genes involved in RA susceptibility, we investigated the association between putative functional single-nucleotide polymorphisms (SNPs) and RA among white individuals by use of a case-control study design; a second sample was tested for replication. Here we report the association of RA susceptibility with the minor allele of a missense SNP in PTPN22 (discovery-study allelic P=6.6 x 10(-4); replication-study allelic P=5.6 x 10(-8)), which encodes a hematopoietic-specific protein tyrosine phosphatase also known as "Lyp." We …
A Systematic Scan Of Chromosome 10 Single Nucleotide Polymorphisms Identifies Novel Candidate Genes Showing Strong Association To Alzheimer's Disease, Steven J. Schrodi
A Systematic Scan Of Chromosome 10 Single Nucleotide Polymorphisms Identifies Novel Candidate Genes Showing Strong Association To Alzheimer's Disease, Steven J. Schrodi
Steven J Schrodi
No abstract provided.
Association Of Late-Onset Alzheimer's Disease With Genetic Variation In Multiple Members Of The Gapd Gene Family, Steven J. Schrodi
Association Of Late-Onset Alzheimer's Disease With Genetic Variation In Multiple Members Of The Gapd Gene Family, Steven J. Schrodi
Steven J Schrodi
No abstract provided.