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Biochemical And Enzymatic Studies Of The Midgut Serine Protease Aaspvii From The Aedes Aegypti Mosquito, James Thientoan Nguyen

Master's Theses

The Aedes aegpyti mosquito is an efficient biological vector of four known neglected tropical arboviruses: the yellow fever, dengue, chikungunya, and Zika viruses. Since the female mosquito can acquire multiple blood meals to complete the gonotrophic cycle, she can potentially infect multiple hosts. With the reemergence of these viruses, especially due to global warming, it is crucial to slow the spread of the mosquito and the blood-borne diseases she transmits. The Ae. aegypti mosquito relies heavily on midgut serine proteases that digest blood meal proteins to provide nutrients required for the egg laying process. The focus of this work is …