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Discriminative Stimulus Effects Of Gabapentin, Michael Zuidema
Discriminative Stimulus Effects Of Gabapentin, Michael Zuidema
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The present study sought to evaluate the discriminative stimulus effects of the anticonvulsant gabapentin in rats trained to discriminate 30.0 mg/kg gabapentin from vehicle in a two-lever drug discrimination task. All of the ten rats tested were able to establish gabapentin as an interoceptive cue. Gabapentin produced full generalization (≥ 80% gabapentin-lever responding) for itself at 30.0, 60.0, and 120.0 mg/kg doses. Pentobarbital produced full substitution, while pregabalin, carbamazepine, fentanyl, and buspirone produced partial substitution (≥ 60% gabapentin-lever responding) for gabapentin. Ethanol and raclopride did not substitute for gabapentin. The psychostimulant amphetamine did not produce substitution; however, the 0.25 mg/kg …