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Convex Relaxations Of A Continuum Aggregation Model, And Their Efficient Numerical Solution, Mahdi Bandegi
Convex Relaxations Of A Continuum Aggregation Model, And Their Efficient Numerical Solution, Mahdi Bandegi
Dissertations
In this dissertation, the global minimization of a large deviations rate function (the Helmholtz free energy functional) for the Boltzmann distribution is discussed. The Helmholtz functional arises in large systems of interacting particles — which are widely used as models in computational chemistry and molecular dynamics. Global minimizers of the rate function (Helmholtz functional) characterize the asymptotics of the partition function and thereby determine many important physical properties such as self-assembly, or phase transitions. Finding and verifying local minima to the Helmholtz free energy functional is relatively straightforward. However, finding and verifying global minima is much more difficult since the …
Quantitative Metrics For Mutation Testing, Amani M. Ayad
Quantitative Metrics For Mutation Testing, Amani M. Ayad
Dissertations
Program mutation is the process of generating versions of a base program by applying elementary syntactic modifications; this technique has been used in program testing in a variety of applications, most notably to assess the quality of a test data set. A good test set will discover the difference between the original program and mutant except if the mutant is semantically equivalent to the original program, despite being syntactically distinct.
Equivalent mutants are a major nuisance in the practice of mutation testing, because they introduce a significant amount of bias and uncertainty in the analysis of test results; indeed, mutants …
Dimension Reduction Techniques For High Dimensional And Ultra-High Dimensional Data, Subha Datta
Dimension Reduction Techniques For High Dimensional And Ultra-High Dimensional Data, Subha Datta
Dissertations
This dissertation introduces two statistical techniques to tackle high-dimensional data, which is very commonplace nowadays. It consists of two topics which are inter-related by a common link, dimension reduction.
The first topic is a recently introduced classification technique, the weighted principal support vector machine (WPSVM), which is incorporated into a spatial point process framework. The WPSVM possesses an additional parameter, a weight parameter, besides the regularization parameter. Most statistical techniques, including WPSVM, have an inherent assumption of independence, which means the data points are not connected with each other in any manner. But spatial data violates this assumption. Correlation between …
Reduction In Salt Deposition On Carbon Nano-Tube Immobilized Membrane During Desalination Via Membrane Distillation, Madihah Saud Humoud
Reduction In Salt Deposition On Carbon Nano-Tube Immobilized Membrane During Desalination Via Membrane Distillation, Madihah Saud Humoud
Dissertations
As water scarcity increases globally under the stresses of increasing demand, aquifer depletion, and climate change, the market for efficient desalination technologies has grown rapidly to fill the void. One such developing technology, membrane distillation (MD), has found much interest in the scientific community. MD has also been powered by solar energy and waste heat resources because it can be operated at relatively low temperatures. Recent studies indicate that MD could potentially achieve the efficiencies of state-of-the-art mature thermal desalination technologies, although additional engineering and scientific challenges must first be overcome.
MD can be used to treat high salinity water …
Customized Boron And Magnesium-Based Reactive Materials Prepared By High Energy Mechanical Milling, Xinhang Liu
Customized Boron And Magnesium-Based Reactive Materials Prepared By High Energy Mechanical Milling, Xinhang Liu
Dissertations
New reactive materials need to be developed having biocidal combustion products. When ignited, such material can add chemical biocidal effects to the common effects of high temperature and pressure. Biocidal combustion products are capable of deactivating harmful spores or bacteria, which can be released by targets containing biological weapons of mass destruction. Research showed that halogens, especially iodine, are effective as biocidal components of reactive material formulations. Recently, magnesium combustion product MgO is also found to have a biocidal effect. Thus, advanced formulations containing both magnesium and iodine are of interest; such formulations are prepared and investigated here.
Reactive materials …
Early Detection Of Fake News On Social Media, Yang Liu
Early Detection Of Fake News On Social Media, Yang Liu
Dissertations
The ever-increasing popularity and convenience of social media enable the rapid widespread of fake news, which can cause a series of negative impacts both on individuals and society. Early detection of fake news is essential to minimize its social harm. Existing machine learning approaches are incapable of detecting a fake news story soon after it starts to spread, because they require certain amounts of data to reach decent effectiveness which take time to accumulate. To solve this problem, this research first analyzes and finds that, on social media, the user characteristics of fake news spreaders distribute significantly differently from those …
Perivascular Waste Metabolites Clearance In Central Nervous System (Cns), Yiming Cheng
Perivascular Waste Metabolites Clearance In Central Nervous System (Cns), Yiming Cheng
Dissertations
Efficient clearance of interstitial waste metabolites is essential for normal brain homeostasis. Such effective clearance is hampered by the lack of a lymphatic system in the brain, and the cerebrospinal fluid (CSF) is unable to clear large size waste metabolites in the brain. Here, a novel idea that brain arterial endothelium and smooth muscle cells reactivity regulates the clearance of these water-insoluble large size waste metabolites through the perivascular dynamic exchange, and that low dose ethanol promotes this perivascular clearance is proposed.
In Aim 1, the biodistribution of a large size waste metabolite (Amyloid-β protein mimic) in rat perivascular space …
Investigation Of Small-Scale Energy Release And Transfer Processes In The Solar Atmosphere With High-Resolution Observations In Infrared, Xu Yang
Dissertations
Solar spectrum in the infrared (IR) contains abundant information of solar activities, however, it has not spectral lines in the solar IR spectrum provide different tools to probe the solar atmosphere in various heights. This radiation band in such relatively long wavelength includes various atom and molecule spectral lines that are generated by relatively small energy level transitions. The temperature-sensitive and highly dynamic spectral lines could reveal the energy transmission process more easily than those in the visible wavelength of solar emission. Moreover, the better magnetic sensitivities for the infrared lines resulting from their longer wavelength make them detect the …
Bio-Inspired Learning And Hardware Acceleration With Emerging Memories, Shruti R. Kulkarni
Bio-Inspired Learning And Hardware Acceleration With Emerging Memories, Shruti R. Kulkarni
Dissertations
Machine Learning has permeated many aspects of engineering, ranging from the Internet of Things (IoT) applications to big data analytics. While computing resources available to implement these algorithms have become more powerful, both in terms of the complexity of problems that can be solved and the overall computing speed, the huge energy costs involved remains a significant challenge. The human brain, which has evolved over millions of years, is widely accepted as the most efficient control and cognitive processing platform. Neuro-biological studies have established that information processing in the human brain relies on impulse like signals emitted by neurons called …
Amyloid Proteins And Fibrils Stability, Farbod Mahmoudinobar
Amyloid Proteins And Fibrils Stability, Farbod Mahmoudinobar
Dissertations
Compared to globular proteins that have a stable native structure, intrinsically disordered peptides (IDP) sample an ensemble of structures without folding into a native conformation.One example of IDP is the amyloid-beta(Abeta) protein which is the main constituent of senile plaques in the brain of Alzheimer's patients.Understanding the process by which IDPs undergo structural changes to form oligomers that eventually aggregate into senile plaques/amyloid fibrils may significantly advance the development of novel therapeutic methods to treat neurodegenerative diseases, for which there is no cure to date. This dissertation has two main objectives. The first one is to investigate and identify structural …
Mitochondria Imaging And Targeted Cancer Treatment, Tinghan Zhao
Mitochondria Imaging And Targeted Cancer Treatment, Tinghan Zhao
Dissertations
Mitochondria are essential organelles as the site of respiration in eukaryotic cells and are involved in many crucial functions in cell life. Dysfunction of mitochondrial metabolism and irregular morphology have been frequently found in human cancers. The capability of imaging mitochondria as well as regulating their microenvironment is important both scientifically and clinically. Mitochondria penetrating peptides (MPPs), certain peptides that are composed of cationic and hydrophobic amino acids, are good candidates for mitochondria targeting. Herein, a novel MPP, D-argine-phenylalanine-D-argine-phenylalanine-D-argine-phenylalanine-NH2 (rFrFrF), is conjugated with a rhodamine-based fluorescent chromophore (TAMRA). The TAMRA-rFrFrF probe exhibits advantageous properties for long-term mitochondria tracking of …
Cerebro-Vascular Disruption Mediated Initiation And Propagation Of Traumatic Brain Injury In A Fluid Percussion Injury Model, Xiaotang Ma
Dissertations
Traumatic brain injury (TBI) is a major health problem for over 3.17 million people in the US. There is no FDA-approved drug for the treatment because the injury mechanisms have not been clearly identified. The knowledge gap is addressed here by the lateral fluid percussion injury (FPI) rat model, through the understanding of layer-structured mechanisms from physical vascular rupture to acute necrosis, as well as biochemical changes in perivascular space as secondary events.
Firstly, the cerebrovascular hemorrhage and related infarct volume are investigated as the primary events in moderate FPI, which is found to be increased with injury severity in …
Topics On High Dimensional Selective Inference, Yan Zhang
Topics On High Dimensional Selective Inference, Yan Zhang
Dissertations
In such applications as identifying differentially expressed genes in micro-array experiments or assessing safety and efficacy of drugs in clinical trials, researchers often report confidence intervals (CIs) and p-values only for the selected parameters, which is called selective inference. While constructing multiple CIs for the selected parameters, it is common practice to ignore issue of selection and multiplicity. Although protection against the effect of selection is sufficient in some cases, simultaneous coverage should be also needed in real applications. For example, in clinical trials, multiple endpoints are considered to assess effects of a drug and the ultimate decision often depends …
Cancer Risk Prediction With Whole Exome Sequencing And Machine Learning, Abdulrhman Fahad M Aljouie
Cancer Risk Prediction With Whole Exome Sequencing And Machine Learning, Abdulrhman Fahad M Aljouie
Dissertations
Accurate cancer risk and survival time prediction are important problems in personalized medicine, where disease diagnosis and prognosis are tuned to individuals based on their genetic material. Cancer risk prediction provides an informed decision about making regular screening that helps to detect disease at the early stage and therefore increases the probability of successful treatments. Cancer risk prediction is a challenging problem. Lifestyle, environment, family history, and genetic predisposition are some factors that influence the disease onset. Cancer risk prediction based on predisposing genetic variants has been studied extensively. Most studies have examined the predictive ability of variants in known …
Lithium As A Possible Therapeutic Drug In Posttraumatic Brain Injury, Tulika Das
Lithium As A Possible Therapeutic Drug In Posttraumatic Brain Injury, Tulika Das
Theses
Lithium, a popular drug for treating mental health disorder has shown promising effect in recent research on traumatic brain injury (TBI). The mechanism of lithium for treating bipolar mood disorder is still not properly understood, but recent studies showed that lithium is neuroprotective in TBI. In my thesis, the neuroprotective effects of lithium were examined in primary neuronal culture and mild blunt injury using rodent model of Lateral Fluid Percussion Injury (LFPI). At first determination of the neuroprotective/toxicity effects of lithium in neuronal culture was done and observed that 0.5 - 1.0 mM concentrations were found to be neuroprotective as …
Dental Professionals Occupational Noise Exposure And Its Auditory And Non-Auditory Effects, Alexis Frees
Dental Professionals Occupational Noise Exposure And Its Auditory And Non-Auditory Effects, Alexis Frees
Theses
The purpose of this study was to assess noise exposure and its auditory and non-auditory effects on workers in five clinical departments in the School of Dental Medicine at Rutgers Biomedical Health Sciences Campus in Newark, New Jersey. The study included environmental noise level measurement, dental instrument sound level measurement, personal noise dosimetry and a questionnaire survey to assess non-auditory effects. Octave band analysis of environmental noise levels showed that they are slightly above the standard noise criteria for clinics, and measurements from six dental instruments confirm that they contribute higher sound pressure levels at the frequencies of 1000, 2000, …
Predictive Modeling Of Influenza In New England Using A Recurrent Deep Neural Network, Alfred Amendolara
Predictive Modeling Of Influenza In New England Using A Recurrent Deep Neural Network, Alfred Amendolara
Theses
Predicting seasonal variation in influenza epidemics is an ongoing challenge. To better predict seasonal influenza and provide early warning of pandemics, a novel approach to Influenza-Like-Illness (ILI) prediction was developed. This approach combined a deep neural network with ILI, climate, and population data. A predictive model was created using a deep neural network based on TensorFlow 2.0 Beta. The model used Long-Short Term Memory (LSTM) nodes. Data was collected from the Center for Disease Control, the National Center for Environmental Information (NCEI) and the United States Census Bureau. These parameters were temperature, precipitation, wind speed, population size, vaccination rate and …
Micro Pipes – A Portable Integrated Platform For Electrochemical Sensing Using Essence Architecture, Hansin Kim
Micro Pipes – A Portable Integrated Platform For Electrochemical Sensing Using Essence Architecture, Hansin Kim
Theses
The field of microfluidics and lab-on-chip (LOC) technology has the potential to have a truly transformative effect in biological engineering. This includes areas such as single-cell analysis, environmental monitoring, regenerative medicine, and point-of-care diagnostics. Yet despite being the subject of intense research over the past two decades, LOC devices have not been widely adopted. It is increasingly evident that there is a need for an effective and adaptable integration strategy to realize the potential of this technology.
Presented in this thesis is a design for a chip-to-world interface that aims to improve integration while maintaining cost-efficiency and ease of fabrication. …
Study And Modelling Of Lithium Ion Cell With Accurate Soc Measurement Algorithm Using Kalman Filter For Electric Vehicles, Kasthuriramanan Mahendravadi Sivaguru
Study And Modelling Of Lithium Ion Cell With Accurate Soc Measurement Algorithm Using Kalman Filter For Electric Vehicles, Kasthuriramanan Mahendravadi Sivaguru
Theses
Lithium Ion cells are preferred over lead acid cells for electric vehicles due to their energy density, higher discharge current and size. The cost of lithium ion cells is scaling down compared to ten years earlier, but as their performance characteristics increase, the need for safety and accurate modelling also increases.
The absence of a generic cell model is associated to the different makes of cells and different chemistries of Lithium ion cells behave differently under the testing conditions required for every unique application. The focus of this thesis will be on how to provide intelligence to the battery management …
Magnetic Field Effects On Lithium Ion Batteries, Kevin Mahon
Magnetic Field Effects On Lithium Ion Batteries, Kevin Mahon
Theses
The Nobel Prize in Chemistry 2019 was just recently awarded to John B. Goodenough, M. Stanley Whittingham, and Akira Yoshino for the development of lithium-ion batteries. Lithium-ion batteries have seen use in many different industries and applications such as in portable devices, power grids, and electric vehicles. As lithium-ion batteries become more commonplace they will need to be modeled more extensively. The magnetic field effect on lithium-ion batteries has not been studied significantly since they were first discovered.
Modeling these batteries is still difficult because of the many complexities of the operation of a battery. Lithium-ion batteries are commonly modeled …
Impact Of Stirrer Speed And Media Type-Loading On The Breakage Kinetics During Wet Stirred Media Milling Of Griseofulvin, Nathaniel Parker
Impact Of Stirrer Speed And Media Type-Loading On The Breakage Kinetics During Wet Stirred Media Milling Of Griseofulvin, Nathaniel Parker
Theses
The aim of this study is to investigate the impact of stirrer speed (2000-4000 rpm) and bead loading (~20-60%) on the breakage kinetics-energy consumption during milling of griseofulvin, a poorly soluble drug, and compare the performance of crosslinked polystyrene (CPS) beads with that of yttrium-stabilized zirconia (YSZ) beads. Laser diffraction, SEM, viscometry, and XRPD were used for characterization. A microhydrodynamic model was used to interpret the breakage kinetics. An increase in stirrer speed led to faster breakage due to more frequent and forceful CPS bead-bead collisions. Despite causing slight decrease in maximum contact pressure, an increase in CPS bead loading …
Effect Of 3d Printed Tablet Shape On Drug Release Profile, Christina Gedeon
Effect Of 3d Printed Tablet Shape On Drug Release Profile, Christina Gedeon
Theses
There is a growing interest in utilizing additive manufacturing (AM) as a manufacturing tool to develop oral tablets for personalized medicine. This ultimate goal in mind, this study explores the feasibility of extrusion-based fused deposition modeling (FDM) to 3D print oral tablets with tunable design to control drug release profile. Tablets are printed using poly(vinyl alcohol) (PVA) loaded with model drugs: acetaminophen and caffeine. Hot melt extrusion (HME) is used to fabricate PVA filaments loaded with acetaminophen and caffeine. These filaments are used to fabricate a range of tablets with varying designs to prepare immediate and delayed release tablets. Thermal …
Digital Citizenship Basic Lessons, Cristo Leon
Digital Citizenship Basic Lessons, Cristo Leon
STEM for Success Resources
Digital Citizenship is one of the international standards for students, educators, administrators, coaches, and computer science educators to rethink education, nevertheless, the language used to present the concept to students has not been sufficiently developed in a holistic manner or with a multi-stakeholder approach. Seeking to bridge the cultural and language barriers that dived the student communities from the academic research communities. The Long Branch Virtual Expert Discussion for Student Leadership reach out to Cristo Leon to present his ideas about some basic lessons to share and discuss with their students. Amongst the challenges that the local communities in New …
Draft For Community Review: Building On A Strong Foundation--Njit 2025, Office Of The Provost
Draft For Community Review: Building On A Strong Foundation--Njit 2025, Office Of The Provost
NJIT 2025
No abstract provided.
Hum 101-035: Writing, Speaking, Thinking I, Morgan Reid
Hum 101-035: Writing, Speaking, Thinking I, Morgan Reid
Humanities Syllabi
No abstract provided.
Eng 507-001: Advanced Conversation And American Culture, Louise Castronova
Eng 507-001: Advanced Conversation And American Culture, Louise Castronova
Humanities Syllabi
No abstract provided.
Thtr 396-661: Internship In Theatre, Michele Rittenhouse
Thtr 396-661: Internship In Theatre, Michele Rittenhouse
Humanities Syllabi
No abstract provided.
Hum 102-013: Writing, Speaking, Thinking Ii, Vanessa Phillips
Hum 102-013: Writing, Speaking, Thinking Ii, Vanessa Phillips
Humanities Syllabi
No abstract provided.
Hum 101-043: Writing, Speaking, Thinking I, Andres Crespo
Hum 101-043: Writing, Speaking, Thinking I, Andres Crespo
Humanities Syllabi
No abstract provided.
Hum 101-049: Writing, Speaking, Thinking I, Miriam Ascarelli
Hum 101-049: Writing, Speaking, Thinking I, Miriam Ascarelli
Humanities Syllabi
No abstract provided.