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Pilot Investigation Of The Relationship Between Hippocampal Volume And Pattern Separation Deficits In Multiple Sclerosis, Mark D. Zuppichini, Joshua Sandry
Pilot Investigation Of The Relationship Between Hippocampal Volume And Pattern Separation Deficits In Multiple Sclerosis, Mark D. Zuppichini, Joshua Sandry
Department of Psychology Faculty Scholarship and Creative Works
Memory impairment and hippocampal atrophy are common in multiple sclerosis (MS). In the present pilot study, we investigate whether the mnemonic process of pattern separation is impaired and a predictor of hippocampal volume in relapsing remitting MS. MS participants and healthy controls completed the Mnemonic Similarities Task (MST) along with traditional neurocognitive assessments of memory. 3T structural magnetic resonance imaging was used to estimate whole hippocampal volumes (main aim) and hippocampal subfield volumes (exploratory aim). Results revealed that pattern separation performance was worse for MS participants compared to healthy controls (Cohen's d = 0.96). For MS participants, hippocampal volume was …
Poor Encoding And Weak Early Consolidation Underlie Memory Acquisition Deficits In Multiple Sclerosis: Retroactive Interference, Processing Speed, Or Working Memory?, Joshua Sandry, Mark Zuppichini, Jessica Rothberg, Zerbrina Valdespino-Hayden, John Deluca
Poor Encoding And Weak Early Consolidation Underlie Memory Acquisition Deficits In Multiple Sclerosis: Retroactive Interference, Processing Speed, Or Working Memory?, Joshua Sandry, Mark Zuppichini, Jessica Rothberg, Zerbrina Valdespino-Hayden, John Deluca
Department of Psychology Faculty Scholarship and Creative Works
Objective: Learning and memory impairments are common in multiple sclerosis (MS) and may be related to difficulty acquiring (encoding or consolidating) new information. We evaluate the role of retroactive interference and investigate whether minimizing interference immediately following encoding (early during consolidation) will improve MS participants' ability to remember new verbal information. Additionally, we investigate processing speed differences between memory-impaired and unimpaired participants and present an exploratory analysis of how the dual-components of working memory (capacity vs. processing) relate to memory impairment. Method: MS memory-unimpaired (N = 12) and MS memory-impaired participants (N = 12) were compared to healthy controls (N …
General Mathematical Ability Predicts Pasat Performance In Ms Patients: Implications For Clinical Interpretation And Cognitive Reserve, Joshua Sandry, Jessica Paxton, James F. Sumowski
General Mathematical Ability Predicts Pasat Performance In Ms Patients: Implications For Clinical Interpretation And Cognitive Reserve, Joshua Sandry, Jessica Paxton, James F. Sumowski
Department of Psychology Faculty Scholarship and Creative Works
Objectives: The Paced Auditory Serial Addition Test (PASAT) is used to assess cognitive status in multiple sclerosis (MS). Although the mathematical demands of the PASAT seem minor (single-digit arithmetic), cognitive psychology research links greater mathematical ability (e.g., algebra, calculus) to more rapid retrieval of single-digit math facts (e.g., 5+6=11). The present study evaluated the hypotheses that (a) mathematical ability is related to PASAT performance and (b) both the relationship between intelligence and PASAT performance as well as the relationship between education and PASAT performance are both mediated by mathematical ability. Methods: Forty-five MS patients were assessed using the Wechsler Test …
Searching For The Neural Basis Of Reserve Against Memory Decline: Intellectual Enrichment Linked To Larger Hippocampal Volume In Multiple Sclerosis, James F. Sumowski, M. A. Rocca, V. M. Leavitt, G. Riccitelli, Joshua Sandry, John Deluca, Giancarlo Comi, Massimo Filippi
Searching For The Neural Basis Of Reserve Against Memory Decline: Intellectual Enrichment Linked To Larger Hippocampal Volume In Multiple Sclerosis, James F. Sumowski, M. A. Rocca, V. M. Leavitt, G. Riccitelli, Joshua Sandry, John Deluca, Giancarlo Comi, Massimo Filippi
Department of Psychology Faculty Scholarship and Creative Works
Background and purpose: Active engagement in intellectually enriching activities (e.g. reading, hobbies) builds 'reserve' against memory decline in elders and persons with multiple sclerosis (MS), but the neural basis for this protective influence of enrichment is unknown. Herein the neuroanatomical basis of reserve against memory decline in MS patients is investigated. Methods: Relapse-onset MS patients (N = 187) underwent 3.0 T magnetic resonance imaging of the brain to quantify T2 lesion volume (T2LV) and normalized volumes of total brain, total white, total grey (using SIENAX) and thalamus, caudate, putamen, pallidum, amygdala and hippocampus (using FIRST). Patients completed a survey quantifying …