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The Response Of Pericytes To Microvascular Ischemia, Robert Gordon Underly
The Response Of Pericytes To Microvascular Ischemia, Robert Gordon Underly
MUSC Theses and Dissertations
The goal of this research is to investigate the role of pericytes during ischemia, and more specifically, to investigate their cell-specific proteolytic contributions that lead to the degeneration of the blood-brain barrier (BBB). BBB degeneration represents a pathological hallmark of ischemic stroke and is a major factor in limiting the window for pharmacological treatments by increasing the likelihood for hemorrhagic transformation. By understanding cell-specific proteolytic contributions to BBB degeneration during ischemia, novel biomarkers to predict the severity of the injury as well as new targets to reduce the extent of damage from stroke could be discovered. Pericytes are a cell …