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Immunoglobulin Κ Chain Allotypes (Km) In Onchocerciasis, Janardan P. Pandey, Lynne H. Elson, Susan E. Sutherland, Ronald H. Guderian, Edmundo Araujo, Thomas B. Nutman
Immunoglobulin Κ Chain Allotypes (Km) In Onchocerciasis, Janardan P. Pandey, Lynne H. Elson, Susan E. Sutherland, Ronald H. Guderian, Edmundo Araujo, Thomas B. Nutman
MUSC Faculty Journal Articles
GM and KM allotypes, powerful tools for genetic characterization of human populations, have been shown to play an important role in genetic predisposition to some infectious diseases. Two diverse racial groups-Afro-Ecuadorians and Amerindians-living in a single restricted geographical area of Ecuador, appear to have different risk factors for acquisition and clinical expression of onchocerciasis, a disease caused by the filarial parasite Onchocerca volvulus. In this study, GM and KM allotypes were determined in 25 Afro-Ecuadorians and 24 Amerindians infected with Onchocerca volvulus (INF) and in putative immune individuals (PI). In Afro-Ecuadorians, the frequency of the homozygous KM 3 phenotype was …