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Heterozygosity At Gm Loci Associated With Humoral Immunity To Osteosarcoma, Janardan P. Pandey, Barry T. Shannon, Kwong Y. Tsang, H. Hugh Fudenberg, John G. Camblin
Heterozygosity At Gm Loci Associated With Humoral Immunity To Osteosarcoma, Janardan P. Pandey, Barry T. Shannon, Kwong Y. Tsang, H. Hugh Fudenberg, John G. Camblin
MUSC Faculty Journal Articles
Familial clustering of osteosarcoma suggests the involvement of genetic factors (1, 2), and the demonstration of a high incidence of osteosarcoma-specific antibodies (3, 4), as well as tumor-specific cell-mediated immunity (5) in patients and their relatives, indicates the involvement of immunological factors in the pathogenesis of this disease. Certain Gm allotypes (genetic markers of IgG) have been shown to be associated with a high relative risk of some forms of cancer. For instance, in Caucasians an unusual Gm haplotype--Gm 1,3;5,13,14--has been found to be associated with neuroblastoma (6), and an increased frequency of Gm (2) has been reported in patients …