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Defective Gut Function In Drop-Dead Mutant Drosophila, Cassandra R. Peller, Elizabeth M. Bacon, Julie A. Bucheger, Edward M. Blumenthal
Defective Gut Function In Drop-Dead Mutant Drosophila, Cassandra R. Peller, Elizabeth M. Bacon, Julie A. Bucheger, Edward M. Blumenthal
Biological Sciences Faculty Research and Publications
Mutation of the gene drop-dead (drd ) causes adult Drosophila to die within 2 weeks of eclosion and is associated with reduced rates of defecation and increased volumes of crop contents. In the current study, we demonstrate that flies carrying the strong allele drdlwf display a reduction in the transfer of ingested food from the crop to the midgut, as measured both as a change in the steady-state distribution of food within the gut and also in the rates of crop emptying and midgut filling following a single meal. Mutant flies have abnormal triglyceride (TG) and glycogen stores …
Cloning Of The Neurodegeneration Gene Drop-Dead And Characterization Of Additional Phenotypes Of Its Mutation, Edward M. Blumenthal
Cloning Of The Neurodegeneration Gene Drop-Dead And Characterization Of Additional Phenotypes Of Its Mutation, Edward M. Blumenthal
Biological Sciences Faculty Research and Publications
Mutations in the Drosophila gene drop-dead (drd) result in early adult lethality and neurodegeneration, but the molecular identity of the drd gene and its mechanism of action are not known. This paper describes the characterization of a new X-linked recessive adult-lethal mutation, originally called lot's wife (lwf1) but subsequently identified as an allele of drd (drdlwf); drdlwf mutants die within two weeks of eclosion. Through mapping and complementation, the drd gene has been identified as CG33968, which encodes a putative integral membrane protein of unknown function. The drdlwf allele is associated …