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In Synch But Not In Step: Circadian Clock Circuits Regulating Plasticity In Daily Rhythms, Jennifer A. Evans, M. R. Gorman
In Synch But Not In Step: Circadian Clock Circuits Regulating Plasticity In Daily Rhythms, Jennifer A. Evans, M. R. Gorman
Biomedical Sciences Faculty Research and Publications
The suprachiasmatic nucleus (SCN) is a network of neural oscillators that program daily rhythms in mammalian behavior and physiology. Over the last decade much has been learned about how SCN clock neurons coordinate together in time and space to form a cohesive population. Despite this insight, much remains unknown about how SCN neurons communicate with one another to produce emergent properties of the network. Here we review the current understanding of communication among SCN clock cells and highlight a collection of formal assays where changes in SCN interactions provide for plasticity in the waveform of circadian rhythms in behavior. Future …
Shell Neurons Of The Master Circadian Clock Coordinate The Phase Of Tissue Clocks Throughout The Brain And Body, Jennifer A. Evans, Ting-Chung Suen, Ben L. Callif, Andrew S. Mitchell, Oscar Castanon-Cervantes, Kimberly M. Baker, Ian Kloehn, Kenkichi Baba, Brett J.W. Teubner, J. Christopher Ehlen, Ketema N. Paul, Timothy J. Bartness, Gianluca Tosini, Tanya Leise, Alec J. Davidson
Shell Neurons Of The Master Circadian Clock Coordinate The Phase Of Tissue Clocks Throughout The Brain And Body, Jennifer A. Evans, Ting-Chung Suen, Ben L. Callif, Andrew S. Mitchell, Oscar Castanon-Cervantes, Kimberly M. Baker, Ian Kloehn, Kenkichi Baba, Brett J.W. Teubner, J. Christopher Ehlen, Ketema N. Paul, Timothy J. Bartness, Gianluca Tosini, Tanya Leise, Alec J. Davidson
Biological Sciences Faculty Research and Publications
Background: Daily rhythms in mammals are programmed by a master clock in the suprachiasmatic nucleus (SCN). The SCN contains two main compartments (shell and core), but the role of each region in system-level coordination remains ill defined. Herein, we use a functional assay to investigate how downstream tissues interpret region-specific outputs by using in vivo exposure to long day photoperiods to temporally dissociate the SCN. We then analyze resulting changes in the rhythms of clocks located throughout the brain and body to examine whether they maintain phase synchrony with the SCN shell or core. Results: Nearly all of the 17 …
Design Of A Passive Ankle Prosthesis With Powered Push-Off Using A Cam Timing Mechanism, Jacob J. Rice
Design Of A Passive Ankle Prosthesis With Powered Push-Off Using A Cam Timing Mechanism, Jacob J. Rice
Master's Theses (2009 -)
This thesis presents the design and simulation results of the CamWalk, a novel passive prosthetic ankle that has mechanical behavior similar to that for a natural ankle. The CamWalk uses a compression spring network that allows coupling between two degrees of freedom; one for translation along the leg and another for rotation about the ankle joint. When walking, potential energy from the person's weight is stored in the spring network in deflection along the leg. The energy is released by the network as rotation of the foot. The amount of translational work that is converted to rotational work about the …