Digital Commons Network^™

Mono-N-Acyl-2,6-Diaminopimelic Acid Derivatives: Analysis By Electromigration And Spectroscopic Methods And Examination Of Enzyme Inhibitory Activity, Jan Hlaváček, Miloslava Vítovcová, Petra Sázelová, Jan Pícha, Václav Vaněk, Miloš Buděšínský, Jiří Jiráček, Danuta M. Gillner, Richard C. Holz, Ivan Mikšík, Václav Kašička

Chemistry Faculty Research and Publications

Thirteen mono-N-acyl derivatives of 2,6-diaminopimelic acid (DAP)—new potential inhibitors of the dapE-encoded N-succinyl-l,l-diaminopimelic acid desuccinylase (DapE; EC 3.5.1.18)—were analyzed and characterized by infrared (IR) and nuclear magnetic resonance (NMR) spectroscopies and two capillary electromigration methods: capillary zone electrophoresis (CZE) and micellar electrokinetic chromatography (MEKC). Structural features of DAP derivatives were characterized by IR and NMR spectroscopies, whereas CZE and MEKC were applied to evaluate their purity and to investigate their electromigration properties. Effective electrophoretic mobilities of these compounds were determined by CZE in acidic and alkaline background electrolytes (BGEs) and by MEKC in acidic and alkaline BGEs …

Disinfection Byproduct Formation Resulting From Settled, Filtered, And Finished Water Treated By Titanium Dioxide Photocatalysis, Brooke K. Mayer, Erin Daugherty, Morteza Abbaszadegan

Civil and Environmental Engineering Faculty Research and Publications

This study evaluated strategies targeting disinfection byproduct (DBP) mitigation using TiO₂ photocatalysis with varying influent water quality. A Purifics Photo-CAT Lab reactor was used to assess total trihalomethane (TTHM) and haloacetic acid (HAA) formation as a function of photocatalytic treatment using water from a conventional coagulation/flocculation/sedimentation process, granular activated carbon filtration, and a DBP hot spot in the water distribution system. Regardless of influent water quality, photocatalysis reduced DBP precursors; however, low-energy limited photocatalysis (m⁻³), exacerbated the production of TTHMs and HAA5s beyond initial levels. Accordingly, limited photocatalysis is not a suitable option when TTHMs and HAA5s …

Video Art: Cultural Transformations, Curtis L. Carter

Philosophy Faculty Research and Publications

In the 1960s, there were efforts to move broadcast television in the direction of the experimental video art by altering television's conventional format. Fred Barzyk, in his role as a producer and director at WGBH-TV in Boston, was uniquely positioned to act as a link between television and experimental video artists who normally would not have had access to the technology available at a major broadcast facility. As the leading innovator in the beginnings of video art, the Korean American Nam June Paik (1932-2006) deserves special mention. His work bridges the worlds of art, video technology, and television. The video …

An Organic Nation: State-Run Tourism, Regionalism, And Food In Spain, 1905–1931, Eugenia Afinoguénova

Spanish Languages and Literatures Research and Publications

No abstract provided.

Protein Expression, Characterization And Activity Comparisons Of Wild Type And Mutant Dusp5 Proteins, Jaladhi Nayak, Adam J. Gastonguay, Marat R. Talipov, Padmanabhan Vakeel, Elise A. Span, Kelsey S. Kalous, Raman G. Kutty, David R. Jensen, Phani Raj Pokkuluri, Daniel S. Sem, Rajendra Rathore, Ramani Ramchandran

Chemistry Faculty Research and Publications

Background

The mitogen-activated protein kinases (MAPKs) pathway is critical for cellular signaling, and proteins such as phosphatases that regulate this pathway are important for normal tissue development. Based on our previous work on dual specificity phosphatase-5 (DUSP5), and its role in embryonic vascular development and disease, we hypothesized that mutations in DUSP5 will affect its function.

Results

In this study, we tested this hypothesis by generating full-length glutathione-S-transferase-tagged DUSP5 and serine 147 proline mutant (S147P) proteins from bacteria. Light scattering analysis, circular dichroism, enzymatic assays and molecular modeling approaches have been performed to extensively characterize the protein form and function. …

Trajectories For The Future: Journalism Studies In Context, Bonnie Brennen

College of Communication Faculty Research and Publications

No abstract provided.

Augmented Cystine–Glutamate Exchange By Pituitary Adenylate Cyclase-Activating Polypeptide Signaling Via The Vpac1 Receptor, Jon M. Resch, Rebecca Albano, Xiaoqian Liu, Julie Hjelmhaug, Doug Lobner, David A. Baker, Sujean Choi

Biomedical Sciences Faculty Research and Publications

In the central nervous system, cystine import in exchange for glutamate through system x_c^- is critical for the production of the antioxidant glutathione by astrocytes, as well as the maintenance of extracellular glutamate. Therefore, regulation of system x_c^- activity affects multiple aspects of cellular physiology and may contribute to disease states. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuronally derived peptide that has already been demonstrated to modulate multiple aspects of glutamate signaling suggesting PACAP may also target activity of cystine–glutamate exchange via system x_c^-. In this study, 24-h treatment of primary cortical …

Turning Labor Into Capital: Pension Funds And The Corporate Control Of Finance, Michael A. Mccarthy

Social and Cultural Sciences Faculty Research and Publications

This article explores union attempts to control pension fund investment for the debate on financial restructuring in the United States. It puts popular control of finance into comparative and historical perspective and argues that laws and politics help explain why the flow of finance is corporate controlled. First, changes in the legal regime—the Taft-Hartley Act of 1947 and the Employee Retirement Income Security Act (ERISA) of 1974—put constraints on labor’s ability to influence investment decisions. This is evident when comparing single- and multi-employer plans, where the laws had different consequences. Second, attempts to reform these laws failed. Had they been …

Intention Tremor And Deficits Of Sensory Feedback Control In Multiple Sclerosis: A Pilot Study, Megan Heenan, Robert A. Scheidt, Douglas Woo, Scott A. Beardsley

Biomedical Engineering Faculty Research and Publications

Background

Intention tremor and dysmetria are leading causes of upper extremity disability in Multiple Sclerosis (MS). The development of effective therapies to reduce tremor and dysmetria is hampered by insufficient understanding of how the distributed, multi-focal lesions associated with MS impact sensorimotor control in the brain. Here we describe a systems-level approach to characterizing sensorimotor control and use this approach to examine how sensory and motor processes are differentially impacted by MS.

Methods

Eight subjects with MS and eight age- and gender-matched healthy control subjects performed visually-guided flexion/extension tasks about the elbow to characterize a sensory feedback control model that …

Reversible Blockade Of Complex I Or Inhibition Of Pkcβ Reduces Activation And Mitochondria Translocation Of P66Shc To Preserve Cardiac Function After Ischemia, Meiying Yang, David F. Stowe, Kenechukwu B. Udoh, James S. Heisner, Amadou K.S. Camara

Biomedical Engineering Faculty Research and Publications

Aim

Excess mitochondrial reactive oxygen species (mROS) play a vital role in cardiac ischemia reperfusion (IR) injury. P66^Shc, a splice variant of the ShcA adaptor protein family, enhances mROS production by oxidizing reduced cytochrome c to yield H₂O₂. Ablation of p66^Shc protects against IR injury, but it is unknown if and when p66^Shc is activated during cardiac ischemia and/or reperfusion and if attenuating complex I electron transfer or deactivating PKCβ alters p66^Shc activation during IR is associated with cardioprotection.

Methods

Isolated guinea pig hearts were perfused and subjected to increasing periods …

Homogenous Ensemble Phonotactic Language Recognition Based On Svm Supervector Reconstruction, Wei-Wei Liu, Wei-Qiang Zhang, Michael T. Johnson, Jia Liu

Electrical and Computer Engineering Faculty Research and Publications

Currently, acoustic spoken language recognition (SLR) and phonotactic SLR systems are widely used language recognition systems. To achieve better performance, researchers combine multiple subsystems with the results often much better than a single SLR system. Phonotactic SLR subsystems may vary in the acoustic features vectors or include multiple language-specific phone recognizers and different acoustic models. These methods achieve good performance but usually compute at high computational cost. In this paper, a new diversification for phonotactic language recognition systems is proposed using vector space models by support vector machine (SVM) supervector reconstruction (SSR). In this architecture, the subsystems share the same …

Behavioral Assessment Of Acute Inhibition Of System XC - In Rats, Victoria Lutgen, Jon M. Resch, Krista Qualmann, Nicholas J. Raddatz, Cristina Panhans, Ellen M. Olander, Linghai Kong, Sujean Choi, John R. Mantsch, David A. Baker

Biomedical Sciences Faculty Research and Publications

Rationale

Gaps in our understanding of glutamatergic signaling may be key obstacles in accurately modeling complex CNS diseases. System x_c ^- is an example of a poorly understood component of glutamate homeostasis that has the potential to contribute to CNS diseases.

Objectives

This study aims to determine whether system x_c ^- contributes to behaviors used to model features of CNS disease states.

Methods

In situ hybridization was used to map mRNA expression of xCT throughout the brain. Microdialysis in the prefrontal cortex was used to sample extracellular glutamate levels; HPLC was used to measure extracellular glutamate and tissue …

Chronic Conditions In Elders In Assisted Living Facilities: Associations With Daily Functioning, Self-Assessed Health, And Depressive Symptoms, Abir K. Bekhet, Jaclene A. Zauszniewski

College of Nursing Faculty Research and Publications

Background

The increasing life expectancy of older adults has prompted an increase in chronic conditions that may interfere with their daily living and impact physical and mental health.

Objectives

This study examined associations between commonly reported chronic conditions, daily functioning, self-assessed health, and depressive symptoms of elders.

Methods/Design

A secondary analysis of existing data from 314 elderly residents of 29 facilities was conducted.

Results

The most frequently reported conditions were arthritis (64%), hypertension (47%), and heart problems (35%). Elders who reported having all three of these most frequently reported conditions differed significantly from those who reported none or one of …

Nurse Value-Added And Patient Outcomes In Acute Care, Olga Yakusheva, Richard C. Lindrooth, Marianne E. Weiss

College of Nursing Faculty Research and Publications

Objective

The aims of the study were to (1) estimate the relative nurse effectiveness, or individual nurse value-added (NVA), to patients’ clinical condition change during hospitalization; (2) examine nurse characteristics contributing to NVA; and (3) estimate the contribution of value-added nursing care to patient outcomes.

Data Sources/Study Setting

Electronic data on 1,203 staff nurses matched with 7,318 adult medical–surgical patients discharged between July 1, 2011 and December 31, 2011 from an urban Magnet-designated, 854-bed teaching hospital.

Study Design

Retrospective observational longitudinal analysis using a covariate-adjustment value-added model with nurse fixed effects.

Data Collection/Extraction Methods

Data were extracted from the study …

On The Compensation And Activity Of Corporate Boards, Nga Nguyen

Finance Faculty Research and Publications

Within the nexus of contracts that makes up the firm, relatively little is known about the relationship between firms and their directors. Using a unique dataset comprising director compensation and activity, I find that firms use meeting fees and equity-based compensation as substitutes. In addition, paying directors for attending board/committee meetings is associated with more active boards and more active monitoring and advising committees. In contrast, a higher proportion of equity-based compensation is positively associated with monitoring activity but negatively associated with advising activity. Furthermore, more active boards and committees are paid more. Finally, I find that the variation in …

Gender Differences In Neighborhood Walking In Older Adults, N. A. Gallagher, P. J. Clarke, Kimberlee A. Gretebeck

College of Nursing Faculty Research and Publications

Objective: This study examined mobility, self-efficacy, outcome expectations, neighborhood (density, destinations, and design), and neighborhood walking in older men (n = 106, 60-99 years, M = 76.78, SD = 8.12) and women (n = 216, 60-99 years, M = 75.81, SD = 8.46).

Method/Results: In hierarchical regression, the variables explained 32% of the variance in neighborhood walking in men (p < .001) and 27% of the variance in women (p < .01). Self-efficacy (β = .49, p < .01), density (β= .22, p < .05), and design (β= .21, p = .05) were associated with walking in men. Significant design characteristics included sidewalks (β= .25, p < .05) and crime (β= .36, p < .01). In women, self-efficacy (β= .48, p < .001) and destinations (β= .15, p < .05) were associated with walking. Walking was associated with self-efficacy for walking despite individual barriers in women (β= .38, p < .001) and neighborhood barriers in men (β= .30, p < .05).

Conclusion: Walking interventions targeting older women should incorporate local destinations. In older …

The $10.10 Minimum Wage Proposal: An Evaluation Across States, Andrew Hanson, Zackary Hawley

Economics Faculty Research and Publications

This paper offers state-level estimates of job loss from increasing the federal minimum wage to $10.10 per hour in 2016. Given the vast differences in nominal wages across geography, a federal increase in minimum wage that is not indexed to local wage levels will have a differential impacts across states. The proposed minimum wage would be binding for between 17 and 18 % of workers nationally. We estimate coverage rates ranging from just 4 % in Washington D.C. to as high as 51 % in Puerto Rico, with 13 states having at least 20 % of the employed population covered …

Review Of Restored To Earth: Christianity, Environmental Ethics, And Ecological Restoration By Gretel Van Wieren, Jame Schaefer

Theology Faculty Research and Publications

No abstract provided.

Creation As An Ecumenical Problem: Renewed Belief Through Green Experience, Thomas Hughson

Theology Faculty Research and Publications

Loss of a sense of creaturehood and of members has occurred across the lines of divided churches in a secular context. The author explores the question whether green experience of nature can be a path toward a renewed sense of creaturehood. Bernard Lonergan’s distinction between faith and belief allows for identifying a primordial faith that interprets the cosmos as numinous. Ignatius of Loyola’s Spiritual Exercises interprets primordial faith with the biblical word of God as Creator. Why not develop local ecumenical experiments in reevangelization that address green experience?

The Role Of Biotin And Oxamate In The Carboxyltransferase Reaction Of Pyruvate Carboxylase, Adam D. Lietzan, Yi Lin, Martin St. Maurice

Biological Sciences Faculty Research and Publications

Pyruvate carboxylase (PC) is a biotin-dependent enzyme that catalyzes the MgATP-dependent carboxylation of pyruvate to oxaloacetate, an important anaplerotic reaction in central metabolism. During catalysis, carboxybiotin is translocated to the carboxyltransferase domain where the carboxyl group is transferred to the acceptor substrate, pyruvate. Many studies on the carboxyltransferase domain of PC have demonstrated an enhanced oxaloacetate decarboxylation activity in the presence of oxamate and it has been shown that oxamate accepts a carboxyl group from carboxybiotin during oxaloacetate decarboxylation. The X-ray crystal structure of the carboxyltransferase domain from Rhizobium etli PC reveals that oxamate is positioned in the active site …

Quantification Of The Statistical Effects Of Spatiotemporal Processing Of Nontask Fmri Data, M. Muge Karaman, Andrew S. Nencka, Iain P. Bruce, Daniel B. Rowe

Mathematics, Statistics and Computer Science Faculty Research and Publications

Nontask functional magnetic resonance imaging (fMRI) has become one of the most popular noninvasive areas of brain mapping research for neuroscientists. In nontask fMRI, various sources of “noise” corrupt the measured blood oxygenation level-dependent signal. Many studies have aimed to attenuate the noise in reconstructed voxel measurements through spatial and temporal processing operations. While these solutions make the data more “appealing,” many commonly used processing operations induce artificial correlations in the acquired data. As such, it becomes increasingly more difficult to derive the true underlying covariance structure once the data have been processed. As the goal of nontask fMRI studies …

Everyone Loves A Winner…Or Do They? Introducing Envy Into A Sales Contest To Increase Salesperson Motivation, Alexander Milovic, Rebecca Dingus

Marketing Faculty Research and Publications

This paper focuses on the role that envy can play in driving sales force behavior in competitions. Envy, an unpleasant emotion that occurs when a person covets something that another has, can be used as a motivating tool to push lower-ranked salespeople to better compete with high achievers. Following a review of envy and sales contest effectiveness, potential strategies are provided for implementing benign envy while avoiding the potential negative consequences of envy. Sales managers must be careful to ensure that envy is induced properly to engage the employees while not negatively affecting the long-term health of the sales force.

Lianas In Gaps Reduce Carbon Accumulation In A Tropical Forest, Stefan A. Schnitzer, Geertje M. F. Van Der Heijden, Joseph Mascaro, Walter P. Carson

Biological Sciences Faculty Research and Publications

Treefall gaps are the “engines of regeneration” in tropical forests and are loci of high tree recruitment, growth, and carbon accumulation. Gaps, however, are also sites of intense competition between lianas and trees, whereby lianas can dramatically reduce tree carbon uptake and accumulation. Because lianas have relatively low biomass, they may displace far more biomass than they contribute, a hypothesis that has never been tested with the appropriate experiments. We tested this hypothesis with an 8‐yr liana removal experiment in central Panama. After 8 years, mean tree biomass accumulation was 180% greater in liana‐free treefall gaps compared to control gaps. …

Effects Of Sex And Gender On Adaptation To Space: Musculoskeletal Health, Lori Ploutz-Snyder, Susan Bloomfield, Scott M. Smith, Sandra K. Hunter, Kim Templeton, Debra Bemben

Exercise Science Faculty Research and Publications

There is considerable variability among individuals in musculoskeletal response to long-duration spaceflight. The specific origin of the individual variability is unknown but is almost certainly influenced by the details of other mission conditions such as individual differences in exercise countermeasures, particularly intensity of exercise, dietary intake, medication use, stress, sleep, psychological profiles, and actual mission task demands. In addition to variations in mission conditions, genetic differences may account for some aspect of individual variability. Generally, this individual variability exceeds the variability between sexes that adds to the complexity of understanding sex differences alone. Research specifically related to sex differences of …

The Never-Ending Struggle: Us Press Coverage Of Contraception 2000–2013, Ana C. Garner, Edgar Mendez

College of Communication Faculty Research and Publications

In 1873, the Comstock Act labeled contraceptive information and materials obscene and banned their distribution. The issue divided the United States then, and it divides the nation today. This essay examines 2000–2013 press coverage of contraception in the New York Times and the Los Angeles Times, two newspapers that have covered contraception since 1873. Press coverage reveals that contemporary efforts to regulate women’s bodies are cloaked in discussions about the Affordable Care Act, religious freedom, morality, and employer rights. Accepting the ideology that contraception is no longer a reproductive rights issue allowed the press to exclude women from …

Correction To “Master Regulators, Regulatory Networks, And Pathways Of Glioblastoma Subtypes”, Serdar Bozdag, Aiguo Li, Mehmet Baysan, Howard A. Fine

Mathematics, Statistics and Computer Science Faculty Research and Publications

No abstract provided.

Remarks On Characterizations Of Malinowska And Szynal, Gholamhossein Hamedani, Z. Javanshiri, Mehdi Maadooliat, A. Yazdani

Mathematics, Statistics and Computer Science Faculty Research and Publications

The problem of characterizing a distribution is an important problem which has recently attracted the attention of many researchers. Thus, various characterizations have been established in many different directions. An investigator will be vitally interested to know if their model fits the requirements of a particular distribution. To this end, one will depend on the characterizations of this distribution which provide conditions under which the underlying distribution is indeed that particular distribution. In this work, several characterizations of Malinowska and Szynal (2008) for certain general classes of distributions are revisited and simpler proofs of them are presented. These characterizations are …

‘The Military Mirror Of Kai’: Swordsmanship And A Medieval Text In Early Modern Japan, Michael Wert

History Faculty Research and Publications

Swordsmanship emerged as a new field of knowledge in early modern Japan (1600–1868), a time of relative peace. During the most violent periods of Japanese history, the latter half of the medieval period (1185–1600), samurai conducted warfare mostly on horseback, using the bow and arrow, or by leading massive armies filled with soldiers who used pikes, halberds, and even firearms. In this paper, I will trace the origins of early modern swordsmanship to the late 16th century during the transition between the medieval and early modern periods, when teachers of swordsmanship and their sword ‘styles’ first appeared in texts. Of …

Direct Numerical Simulations Of Non-Premixed Ethylene–Air Flames: Local Flame Extinction Criterion, Vivien R. Lecoustre, Paul G. Grias, Somesh P. Roy, Zhaoyu Luo, Dan C. Haworth, Hong G. Im, Tianfeng F. Lui, Arnaud Trouvé

Mechanical Engineering Faculty Research and Publications

Direct Numerical Simulations (DNS) of ethylene/air diffusion flame extinctions in decaying two-dimensional turbulence were performed. A Damköhler-number-based flame extinction criterion as provided by classical large activation energy asymptotic (AEA) theory is assessed for its validity in predicting flame extinction and compared to one based on Chemical Explosive Mode Analysis (CEMA) of the detailed chemistry. The DNS code solves compressible flow conservation equations using high order finite difference and explicit time integration schemes. The ethylene/air chemistry is simulated with a reduced mechanism that is generated based on the directed relation graph (DRG) based methods along with stiffness removal. The numerical configuration …

The Economic Costs And Benefits Of Dental Education: An Empirical Analysis, Gary L. Stafford, Farrokh Nourzad, William K. Lobb, Jason R. Beall

School of Dentistry Faculty Research and Publications

The rising costs associated with obtaining a dental education have caused some to question the financial benefit of pursuing a dental degree. There is a concern that recent graduates may have difficulty finding professional opportunities that provide the income necessary to service their accumulated educational debt. The aim of this study was to evaluate the trends in educational costs to aid in making an accurate appraisal of the financial benefit of a dental education. Adjusted into constant dollar terms, data from a variety of sources were collected for economic variables such as tuition, fees, student indebtedness, and dentists’ earnings. These …