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The Role Of Membrane Porosity In Ion Removal By Ro/Nf Membranes And Development Of A Regenerable Pac-Loaded Membrane, Yizhi Hou
Dissertations (1934 -)
Reverse osmosis (RO) and nanofiltration (NF) membranes are widely used for water treatment applications. They are charged porous materials, in which size exclusion and charge exclusion work together to dictate solute transport. In this study, membrane porosity was primarily determined by pore size. Thicker, more porous membranes with smaller pores had higher NaCl removal and less permeate water flux. Higher porosity membranes have greater inner pore surface area available to support a greater number of functional groups, thereby rejecting ion flux and increasing ion removal. The Donnan steric pore model (DSPM) was used to determine that the contribution of diffusion …
More Than “Just A Friend”: Exploring The Therapeutic Needs Of Adult Survivors Of A Suicide Loss Of A Friend, Kat R. Mcconnell
More Than “Just A Friend”: Exploring The Therapeutic Needs Of Adult Survivors Of A Suicide Loss Of A Friend, Kat R. Mcconnell
Dissertations (1934 -)
Individuals who are bereaved by the suicide loss of a loved one (also known as “suicide survivors”) face high rates of complicated grief, mental illness, social isolation, experiences of stigma, and suicide attempts. While suicide loss therapy (or “postvention”) attracts many individuals grieving familial suicides, those impacted by the suicide loss of a close friend are underrepresented in both individual and group therapies, despite indications that friend suicide survivors are impacted at an equivalent level and frequency to family members. Using a constructivist grounded theory method, this study aimed to investigate the lived experiences and therapeutic needs of 8 adults …
A Public Policy Analysis Of An Allied Health Career Pathway Model At A Local Technical College, Rebecca A. Garcia Sanchez
A Public Policy Analysis Of An Allied Health Career Pathway Model At A Local Technical College, Rebecca A. Garcia Sanchez
Dissertations (1934 -)
Policymakers, philanthropists, and related stakeholders assert that education is “the civil rights issue of our generation” (The White House, n.d). In turn, a career-based business model where “career and technical education encourages employability” (Wilder, 2013) has been implemented, providing readily accessible post-secondary opportunities to address perpetual societal inequality. Many stakeholders perceive the two-year institution as helping bridge the perpetual equity gap by creating access streams needed to acquire good-paying jobs. Because of the diverse socioeconomic student narrative within the Midwestern technical college, a study inquiry was conducted to ascertain the institution’s ability to reproduce the desired results advertised by public …
Characterizing Allosteric Regulation And Conformational Dynamics In Staphylococcus Aureus Pyruvate Carboxylase, Amanda Joan Laseke
Characterizing Allosteric Regulation And Conformational Dynamics In Staphylococcus Aureus Pyruvate Carboxylase, Amanda Joan Laseke
Dissertations (1934 -)
Pyruvate carboxylase (PC) produces oxaloacetate from pyruvate and bicarbonatein an ATP-dependent manner. The catalytic activity of PC places it at a pivotal intersection between catabolism and anabolism. Understanding the essential metabolic role of PC requires a more complete description of how its activity is regulated and how that regulation is manifested through changes in conformational dynamics. PC activity is regulated by the mutually exclusive binding of the allosteric activator, acetyl-CoA, and the allosteric inhibitor, L-aspartate. The binding site for acetyl- CoA has largely been identified, but the binding location for the acetyl moiety is unknown. Given that the acetyl moiety …
Metal Organic Frameworks (Mofs) Supported Single Atom Catalysts (Sacs) For Solar Fuel Conversion, Humphrey Chiromo
Metal Organic Frameworks (Mofs) Supported Single Atom Catalysts (Sacs) For Solar Fuel Conversion, Humphrey Chiromo
Dissertations (1934 -)
The continual reliance on non-renewable energy sources from fossil fuels to meet the world’s energy demand is causing serious environmental problems such as air pollution and global warming, hence there is a need of an alternative clean sustainable energy source. Exploration of clean sustainable renewable energies shows great promise to replace fossil fuels to meet global energy needs. Among the renewable energy sources, solar energy represents one of the most promising alternative energy sources due to its abundance and sustainability. However, the major challenge is the harvesting and storage of solar energy. One of the promising approaches to resolve these …
Magnetic Endothelialization Of Flow Diverters To Promote Rapid Healing Of Cerebral Aneurysms, Amanda Thome
Magnetic Endothelialization Of Flow Diverters To Promote Rapid Healing Of Cerebral Aneurysms, Amanda Thome
Dissertations (1934 -)
Cerebral aneurysms are dilations of normal vasculature in the brain. When patients are diagnosed with a cerebral aneurysm there are many different treatment options, but one of the newest treatments is flow diversion. Flow diverters create a barrier over the neck of the aneurysm that restores flow to the parent vessel and away from the aneurysm. While these devices have high success rates thus far, they are still associated with some clinical issues such as in-stent thrombosis, delayed aneurysmal occlusion, and side brand occlusion. To mitigate this the current standard of treatment includes a dual anti-platelet therapy regimen which poses …
Application Of The Social Determinants Of Health To Geriatric Patients By Nurse Practitioner Students, Theresa Marie Gruenke Schnable
Application Of The Social Determinants Of Health To Geriatric Patients By Nurse Practitioner Students, Theresa Marie Gruenke Schnable
Dissertations (1934 -)
ABSTRACT APPLICATION OF THE SOCIAL DETERMINANTS OF HEALTH TO GERIATRIC PATIENTS BY NURSE PRACTITIONER STUDENTS Patient outcomes are influenced by the social determinants of health (SDOH), which influence differing exposures to opportunities or health risks. Holistic care of geriatric patients includes considering SDOH in patient assessment, diagnosis, and care delivery. Understanding how NP students care for geriatric patients using a SDOH lens provides insight into their practice behaviors and helps educators understand how to strengthen NP programs to achieve better patient outcomes and advance health equity for the geriatric population. The purpose of this study was to describe how NP …
Comparison Of A Patient-Specific Computed Tomography Organ Dose Software With Commercial Phantom-Based Tools, Bindu P. Bhat
Comparison Of A Patient-Specific Computed Tomography Organ Dose Software With Commercial Phantom-Based Tools, Bindu P. Bhat
Dissertations (1934 -)
Computed Tomography imaging is an important diagnostic tool but carries some risk due to radiation dose used to form the image. Currently, CT scanners report a measure of radiation dose for each scan that reflects the radiation emitted by the scanner, not the radiation dose absorbed by the patient. The radiation dose absorbed by organs, known as organ dose, is a more relevant metric that is important for risk assessment and CT protocol optimization. Tools for rapid organ-dose estimation are available but are limited to using general patient models. These publicly available tools are unable to model patient-specific anatomy and …
Tracking Formation Changes And Its Effects On Soccer Using Position Data, Jinho Kim
Tracking Formation Changes And Its Effects On Soccer Using Position Data, Jinho Kim
Dissertations (1934 -)
This study investigated the application of advanced machine learning methods, specifically k-means clustering, k-Nearest Neighbors (kNN), and Support Vector Machines (SVM), to analyze player tracking data in soccer. The primary hypothesis posits that such data can yield a standalone, in-depth understanding of soccer matches. The study revealed that while k-means and spatial analysis are promising in analyzing player positions, kNN and SVM show limitations without additional variables. Spatial analysis examined each team’s convex hull and studied the correlation between team length, width, and surface area. Results showed team length and surface area have a strong positive correlation with a value …
Exemplar Trans-Affirmative Therapists: A Consensual Qualitative Research Study, Shannon Skaistis
Exemplar Trans-Affirmative Therapists: A Consensual Qualitative Research Study, Shannon Skaistis
Dissertations (1934 -)
The consensus approach for psychotherapy with transgender and nonbinary clients (TNB) has come to be known as trans-affirmative psychotherapy (TAP). TAP is influenced by a collection of guidelines and models (American Counseling Association [ACA], 2010; APA, 2015; Chang et al., 2017; Singh & dickey, 2017) and a small number of empirical studies related to psychotherapy with transgender clients (e.g., Elder, 2016; McCullough et al., 2017, Mizock & Lundquist, 2016, Morris et al., 2020). However, the limited empirical research and guidelines provide minimal direction to clinicians working in-session with TNB clients. This study sought to investigate the perceptions of exemplar clinicians’ …
Developing Continuous Predictive Controls For Ankle Angle And Moment Across Multiple Mobility Tasks, John Eganhouse
Developing Continuous Predictive Controls For Ankle Angle And Moment Across Multiple Mobility Tasks, John Eganhouse
Master's Theses (2009 -)
This thesis aimed to create a predictive model for controlling lower limb prostheses, using electrical activity from muscles in the residual limb to predict ankle angle and moment across mobility tasks including level ground walking, stair ascent, and descent (LW, SA, and SD). In aim 1, kinematic and kinetic ankle data, were used together with electromyographic (EMG) signals obtained from six healthy ambulators to train a nonlinear autoregressive (NARX) model to predict ankle angle and moment. Networks were trained with a delay of 58.33 ms, using a 120 ms sampling window and tested for their ability to predict ankle angle …
Internalizing Symptoms In Autistic Young Adults: Comparing The Cognitive And Physiological Components Of Emotion Regulation, Sarah Lehman
Internalizing Symptoms In Autistic Young Adults: Comparing The Cognitive And Physiological Components Of Emotion Regulation, Sarah Lehman
Master's Theses (2009 -)
Autistic people experience co-occurring mental illness at a substantially greater rate compared to their neurotypical counterparts. Of these comorbid psychopathologies, internalizing disorders (anxiety and depression) are among the most prevalent. Emotion dysregulation has been identified as a contributing factor to this phenomenon and potential treatment target. The current study employed cognitive (e.g., use of suppression and use of cognitive reappraisal) and physiological (e.g., respiratory sinus arrhythmia (RSA) and heart period) measures to more holistically capture the multifaceted construct of emotion regulation compared to prior research. In a sample of autistic young adults (N = 63) ages 17-29 (M = 20.14), …
Reduced Bias User Preference Methods For Determining The Pareto-Optimal Solution Point, Dylan Thomas Johnson
Reduced Bias User Preference Methods For Determining The Pareto-Optimal Solution Point, Dylan Thomas Johnson
Master's Theses (2009 -)
Engineering design is filled with tradeoffs between competing objectives such as performance, mass, cost, and schedule. A designer must navigate these complex multi-objective problems and deliver the right solution for their application. Multi-objective optimization techniques are powerful and widely used; however, a key drawback to these techniques is that they often output a set of equivalent solutions called the Pareto Front. The designer must perform an additional multi-objective down selection on the Pareto Front to determine a single Pareto-optimal solution point for their design. Existing Pareto Front processing techniques either use traditional infinitely adjustable weights, which can yield results that …
Design And Validation Of A Variable Stiffness Three Degree Of Freedom Planar Robot Arm, Andrew L. Bernhard
Design And Validation Of A Variable Stiffness Three Degree Of Freedom Planar Robot Arm, Andrew L. Bernhard
Master's Theses (2009 -)
The need exists for robotic manipulators that can interact with an environment having uncertain kinematic constraints. A robot has been designed and built for proof of concept of a passive variable compliance control strategy that can vary joint stiffness to achieve higher performance dexterous manipulation. This novel planar robot incorporating variable stiffness actuators and common industrial controls allows the robot to comply with its environment when needed but also have high stiffness for precise motion control in free space. To perform both functions well, a high stiffness ratio (max/min stiffness) is required. A stiffness ratio up to 492 was achieved. …
Improving Benign Paroxysmal Positional Vertigo Diagnosis, Sida Zhang
Improving Benign Paroxysmal Positional Vertigo Diagnosis, Sida Zhang
Master's Theses (2009 -)
Benign Paroxysmal Positional Vertigo (BPPV) is one of the most common causes of dizziness. Especially for people over 45, the risk of BPPV is substantial. On the other hand, BPPV is often misdiagnosed and may require expensive examinations. This thesis introduces a prediction model based on machine learning to quickly, inexpensively, and accurately diagnose BPPV. The thesis starts by introducing BPPV and the statistics of BPPV misdiagnosis. Then, a patient survey is introduced. The patient survey includes 50 BPPV-related questions, which are used as training data for the machine learning model. Logistic Regression, Decision Tree, and Naïve Bayes were compared …
Creep Resistance And Microstructure In Binary Aluminum Cerium Alloy Produced By Laser Powder Bed Fusion, Jillian Ann Stinehart
Creep Resistance And Microstructure In Binary Aluminum Cerium Alloy Produced By Laser Powder Bed Fusion, Jillian Ann Stinehart
Master's Theses (2009 -)
Currently, the only commercially available aluminum alloy for additive manufacturing (AM) is AlSi10Mg, which is not suitable for high temperature applications. Al-Ce based alloys have been shown to be highly printable, cost-efficient alloys. Compared to cast Al-Ce alloys, the eutectic features are refined (<1μm), which give AM Al-10Ce favorable strength and ductility at room temperature. The low diffusivity and solubility of cerium in aluminum improve the retention of mechanical properties at high temperatures. In order to quantify the effect of cerium on the thermal stability of AM aluminum and show its suitability for high-temperature applications, Al-10Ce was creep tested between 60-77% of its absolute melting temperature. The creep performance of AM Al-10Ce was favorable compared to that of cast binary Al-Ce and AM AlSi10Mg and was comparable to that of cast ternary Al-Ce alloys. The stress exponent, n, was approximately 1 in the low stress regime and 5-7 in the high stress regime. The activation energy was 231kJ/mol. In comparison, both cast binary Al-Ce and AM AlSi10Mg have higher stress exponents and lower activation energies, showing AM Al-10Ce to be more creep resistant. After creep testing, slight grain coarsening was observed, while grain orientation remained unchanged. The melt pool boundaries (MPBs) faded in appearance after creep testing, and the number of columnar grains decreased.
Ecumenical Traditions: Byzantine And Franciscan Theology In Dialogue, Gino G. Grivetti
Ecumenical Traditions: Byzantine And Franciscan Theology In Dialogue, Gino G. Grivetti
Master's Theses (2009 -)
This thesis investigates the convergences between the Byzantine and Franciscan traditions in the areas of hagiography, mysticism, and dogmatic theology. Historically marginalized in the neo-scholastic synthesis of the nineteenth century, the closeness of Patriarch Bartholomew (b. 1940) and Pope Francis (b. 1936) has symbolized the significance of this dialogue in the modern ecumenical movement. The anonymous bios of St. Nilus of Rossano (d. 1005) and the first vita of St. Francis of Assisi (d. 1226) by Thomas of Celano (d. 1260) are representative of the hagiographical traditions of the Italo-Byzantine monks and the early Franciscans. The traditions came into direct …
The Universality Of God In Amo’S Oracles And Creation: A Historical-Critical Approach Within A Catholic Context, Alexandra Bochte
The Universality Of God In Amo’S Oracles And Creation: A Historical-Critical Approach Within A Catholic Context, Alexandra Bochte
Master's Theses (2009 -)
In the Old Testament, the Israelite nation is identified as a chosen people of God and in a covenantal relationship with him. This thesis will argue that the Noahide covenantal relationship extends to more than just the Israelites such that all creation is in a covenant with the universal God. This is supported through an exploration of Ancient Near Eastern literature and its similarities with biblical stories. Exegetical analyses of Psalms and prophetic biblical literature will further demonstrate God’s universality and will elucidate what it means to be in a covenantal relationship with God. When there is relationship there must …
Maxillary And Mandibular Incisor And Molar Dentoalveolar Heights In Untreated Subjects Presenting Class I And Class Ii Malocclusion, Samantha Zavada Cardinal
Maxillary And Mandibular Incisor And Molar Dentoalveolar Heights In Untreated Subjects Presenting Class I And Class Ii Malocclusion, Samantha Zavada Cardinal
Master's Theses (2009 -)
Objective : Class II malocclusion has been extensively studied, however there are many unanswered questions. This study analyzed the difference in incisor and molar dentoalveolar heights of untreated subjects presenting with Class I and Class II malocclusion. Dentialveolar heights are an aspect of the craniofacial complex that changes with growth and development and are manipulated by orthodontists. These changes hold important clinical implications for the development, maintenance and treatment of malocclusions. Methods : A sample of 96 untreated Class I and Class II subjects, with a total of 611 cephalograms was drawn from the archives of the University of Michigan …
Alveolar Bone Remodeling In Response To Orthodontic Tooth Movement, Matthew Raymond Mcgrady
Alveolar Bone Remodeling In Response To Orthodontic Tooth Movement, Matthew Raymond Mcgrady
Master's Theses (2009 -)
Objective: Dental protrusion and retrusion are common malocclusions in clinical orthodontics. When teeth are moved orthodontically, the alveolar bone surrounding the teeth remodels. In the past, incisor retraction-associated alveolar bone remodeling has been studied. However, less is known about the alveolar bone remodeling after incisors are proclined. This study aimed to assess the changes in alveolar bone thickness after proclination of maxillary incisors. The null hypothesis was that there is no difference in the surrounding alveolar bone thickness after orthodontic tooth movement. Materials and Methods: Patients were selected under the inclusion criteria of moderate-to-severe bimaxillary dental retrusion (U1-SN < 97°, L1-MP < 88.0°), absence of craniofacial anomalies, non-extraction, absence of missing teeth, with quality pre-and post-treatment lateral cephalometric images. Nineteen patients (10 males, 9 females; mean age 14.7 years) were selected, and their pre-treatment and post-treatment lateral cephalograms were digitally traced using a customized cephalometric analysis to compare changes in labial and lingual alveolar bone thickness (ABT) after orthodontic treatment. A two-sample t-test with R statistical software version 4.1.2 was used to measure the differences between the pre- and post-treatment cephalometric measurements. A p value less than 0.05 was considered statistically significant. Results: According to the SN-7° measurement method, ABT increased at the labial(b) SN-7 (0.27mm ± 0.70; p<0.05) and U1 labial(c) SN-7 (0.79mm ± 1.56; p<0.05) levels; however, ABT decreased at the U1 lingual (c) SN-7 (1.13mm ± 1.35; p<0.05) level. According to the perpendicular of the long axis of U1 root measurement method, ABT increased at the U1 labial(c) ⊥U1 (0.55mm ± 1.35; p<0.05) level while ABT decreased at the U1 lingual (b) ⊥U1 (0.79mm ± 1.03; p<0.05) and U1 lingual (c) ⊥U1 (1.61mm ±1.39; p<0.05) levels. Statistically significant changes were also found in post-treatment incisor angulation U1-SN° (8.05° ± 8.25; p<0.05), U1 – NA° (7.44° ± 8.08; p < 0.05) and post-treatment incisor position U1 – NA (mm) (1.64mm ± 2.63; p<0.05). Conclusion:The null hypothesis was rejected based on our results. There are statistically significant changes to the labial and lingual alveolar bone (ABT) after proclination of the maxillary incisors. Our data support previous findings in orthodontics literature. Further studies should be conducted that can employ larger sample sizes with imaging methods that overcome the limitations of conventional two-dimensional imaging.
Deep Learning Classification Of Deep Ultraviolet Fluorescence Images For Margin Assessment During Breast Cancer Surgery, Tyrell To
Master's Theses (2009 -)
Breast-conserving surgery (BCS) is a widely used treatment for breast cancer, but ensuring the complete removal of cancer cells from the surgical margins remains a challenge. Deep ultraviolet (DUV) fluorescence scanning microscopy offers a potential solution by providing real-time whole-surface imaging of resected tissues during BCS. However, interpreting DUV images for margin assessment requires an automated classification method. This dissertation addresses this need by proposing a deep learning-based classification approach for DUV fluorescence images in intra-operative margin assessment of breast cancer.To overcome the limited availability of DUV image datasets and potential over- fitting, the study combines patch-level classification using transfer …
Reducing Porosity In Lpbf Ti-6al-4v By Parameter Optimization And Low Temperature Hot Isostatic Pressing Cycle, Penn Rawn
Master's Theses (2009 -)
Powder bed based additive manufacturing has advantages in its ability to make specialized parts with complex geometries. Unfortunately, components made through such processes of suffer from manufacturing defects including porosity. To study pore formation and removal, specimens of Ti-6Al-4V were built at varied levels of laser power, travel speed, hatch spacing, and layer thickness to obtain a variety of initial defect populations. The specimens were then subjected to a hot isostatic pressure (HIP) at 850 °C and 200 MPa to evaluate the low temperature high pressure (LTHP) cycle’s ability to remove pores. Image analysis was used to estimate the relative …
Trinitarian Theology As A Resource For The Theology Of Education, Anne Bullock
Trinitarian Theology As A Resource For The Theology Of Education, Anne Bullock
Master's Theses (2009 -)
The character of Catholic education has been variously described but is often associated with educating the whole person, a statement that is usually inadequately explored. In the first place, this “holistic” approach is often reduced to character education, which is an insufficient explanation of what makes Catholic schools distinctive. Moreover, the approach relies on a dense theological account of the human person, which can make it difficult to integrate into the daily reality of school life. This thesis critiques some insufficient approaches to Catholic education in light of the Church’s vision for education, beginning with Vatican II and Gravissimis Educationis …
Efficacy Of, And Preference For, A Modification To Differential Reinforcement Procedures, Carissa Basile
Efficacy Of, And Preference For, A Modification To Differential Reinforcement Procedures, Carissa Basile
Dissertations (1934 -)
Tic disorders, such as Tourette’s Syndrome, are chronic, childhood-onset neurological conditions that involve sudden, repetitive, and involuntary motor movements and/or vocalizations. Individuals with tics often experience a premonitory urge, which is an aversive sensation that occurs right before a tic that may functionally influence tics. Previous research has suggested reinforced tic suppression can effectively reduce tics. Although effective, it may be useful to better understand the behavioral contingencies that most effectively lead to suppression. The purpose of the current study was to compare standard reinforced tic suppression with reinforced tic suppression that included an option for participant-initiated breaks using an …
The Effect Of Microstructural Defects And Geometrical Features On Fatigue Behavior Of Superelastic Nitinol Wires, Parisa Shabani Nezhad
The Effect Of Microstructural Defects And Geometrical Features On Fatigue Behavior Of Superelastic Nitinol Wires, Parisa Shabani Nezhad
Dissertations (1934 -)
Nitinol is an alloy of nickel and titanium, which exhibits outstanding functional properties, such as shape memory and superelastic behavior. Superelastic nitinol wires exhibit recoverable strains that are significantly greater than traditional alloys. In most of its applications, nitinol is exposed to cyclic loads, which results in functional and/or structural fatigue that ultimately leads to failure. The classical fatigue theories do not appropriately address the fatigue performance of superelastic nitinol due to the complex nature of the martensitic transformation. It has been shown that the main fatigue crack initiation sites, other than surfaces, are microstructural inhomogeneities such as voids and …
Why We Work: Exploring The Relationships Between Work Rewards, Burnout, And Intention To Leave For Professional Nurses, Jacqueline Christianson
Why We Work: Exploring The Relationships Between Work Rewards, Burnout, And Intention To Leave For Professional Nurses, Jacqueline Christianson
Dissertations (1934 -)
Nurse burnout leads to attrition from hospital nursing positions and the nursing profession prior to typical retirement age. Yet some nurses choose to stay despite burnout. Previous research indicates that nurses stay due to the rewards they receive from work but the relationships between different types of work rewards, work-related burnout, and intention to leave are poorly described. The ability to implement or execute altruistic behaviors may also represent an under-recognized work reward. Thus, the purpose of this study is to investigate the relationships between work rewards, work-related burnout, and intention to leave nursing positions and the nursing profession and …
Designing Human-Centered Algorithms For The Public Sector: A Case Study Of The U.S. Child Welfare System, Devansh Saxena
Designing Human-Centered Algorithms For The Public Sector: A Case Study Of The U.S. Child Welfare System, Devansh Saxena
Dissertations (1934 -)
Public sector agencies in the United States are increasingly seeking to emulate business models of the private sector centered in efficiency, cost reduction, and innovation through the adoption of algorithmic systems. These data-driven systems purportedly improve decision-making; however, the public sector poses its own unique challenges where policies, practices, and organizational constraints mediate all decisions. Algorithms that do not account for these pertinent aspects of professional practice frustrate practitioners, diminish the quality of human discretionary work, and amplify biases in decision-making. A human-centered research agenda can help us develop algorithms centered in social-ecological theories that support the decision-making processes of …
Exploring Validation And Success Among First-Generation College Students In First-Year Writing, Jenna Green
Exploring Validation And Success Among First-Generation College Students In First-Year Writing, Jenna Green
Dissertations (1934 -)
This qualitative case study examines connections between student writing and student success, specifically among first-generation college students, a growing student population who are less likely to graduate college than their multigenerational peers. First-generation college students are more likely to come from working-class, low-income backgrounds, identify as racial or ethnic minorities, live at home and/or have significant family and work responsibilities (Bond, 2019; Engle & Tinto, 2008). Due to the confluence of barriers many face, first-generation college students exhibit higher attrition rates, contributing to persisting inequities in higher education. Leveraging Rendón’s (1994) validation theory, this study explored how first-generation college students …
Elucidating The Structure And Regulatory Interactions Of The Hotair Non-Coding Rna And The Bacterial Rnase P. Holoenzyme, Ainur Abzhanova
Elucidating The Structure And Regulatory Interactions Of The Hotair Non-Coding Rna And The Bacterial Rnase P. Holoenzyme, Ainur Abzhanova
Dissertations (1934 -)
RNA structures and RNA-protein interactions are studied as potential drug targets, biomarkers in cancer, and can be administered as vaccines. The cancer associated HOTAIR (HOX transcript antisense RNA) exists in higher vertebrates and interacts with chromatin remodeling enzymes. We examined the thermodynamic folding properties and structural propensity of the exonic regions of HOTAIR using biophysical methods and NMR spectroscopy. Different exons of HOTAIR contain variable degrees of structural heterogeneity. We identify one exonic region, exon 4, that adopts a stable and compact fold under low magnesium concentrations. Close agreement of NMR spectroscopy and chemical probing confirm conserved base pair interactions …
Artificial Intelligence-Based Smarter Accessibility Evaluations For Comprehensive And Personalized Assessment, Sayeda Farzana Aktar
Artificial Intelligence-Based Smarter Accessibility Evaluations For Comprehensive And Personalized Assessment, Sayeda Farzana Aktar
Dissertations (1934 -)
The research focuses on utilizing artificial intelligence (AI) and machine learning (ML) algorithms to enhance accessibility for people with disabilities (PwD) in three areas: public buildings, homes, and medical devices. The overarching goal is to improve the accuracy, reliability, and effectiveness of accessibility evaluation systems by leveraging smarter technologies. For public buildings, the challenge lies in developing an accurate and reliable accessibility evaluation system. AI can play a crucial role by analyzing data, identifying potential barriers, and assessing the accessibility of various features within buildings. By training ML algorithms on relevant data, the system can learn to make accurate predictions …