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Health Information Seeking As A Coping Strategy To Reduce The Stress Of Informal Caregivers Of Individuals With Alzheimer’S Disease And Other Forms Of Dementia, Nia Francis Mason

LSU Doctoral Dissertations

This study explored the relationship between information seeking and the perceived stress levels of informal Alzheimer’s and dementia caregivers. An additional component was added to determine whether health literacy and emotional state moderated the relationship.

The study involved conducting qualitative interviews followed by collecting survey data to answer the following research questions: 1) What motivating factors lead informal AD caregivers to seek out information? How do their information needs change? Why do informal caregivers choose to utilize certain resources more than others? Is there a correlation between information seeking and resulting stress levels? Does health literacy moderate the association between …

The Drosophila Neuroblasts: A Model System For Human Ribosomopathies, Sonu Shrestha Baral

LSU Doctoral Dissertations

This dissertation describes the use of Drosophila neuroblasts (NBs) to model human ribosomopathies; the overall goal is to understand why specific stem cell and progenitor cell populations are the primary targets in nucleolar stress as seen in the ribosomopathies. Chapter 1 provides an overview of relevant literature. Chapter 2 describes nucleolar stress in Drosophila neuroblasts as a model for human ribosomopathies. For this, we induce nucleolar stress by using the UAS-GAL4 system to express RNAi that depletes Nopp140 transcripts, and we also employ homozygous, CRISPR-Cas9-generated Nopp140 gene disruptions with a systemic null phenotype (Nopp140-/-). Embryonic lethality was observed …

Impact Of Psychological And Physical Stressors On The Exercise-Induced Immune Response In Collegiate Swimmers, Connor Alexander Kuremsky

LSU Master's Theses

Evidence suggests high-intensity exercise training increases incidence of upper respiratory infection in young-adult athletes (Spence et al. 2007). Collegiate athletes experience chronic stress, which has been shown to result in increased proportions of late-differentiated CD8+ T-cells of a dysfunctional phenotype (Bosch et al. 2009). However, many studies fail to consider possible moderators such as psychological stress and cytomegalovirus (CMV) infection. Purpose: To examine the impact of psychological stress, CMV infection, and exercise on proportions of early- and late-differentiated CD4+ and CD8+ T-cells in collegiate swimmers over a 7-month training period. Methods: Data were collected from NCAA …