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S14rs Sgr No. 30 (Food Allergens - Lsu Dining), Gore
S14rs Sgr No. 30 (Food Allergens - Lsu Dining), Gore
Student Senate Enrolled Legislation
No abstract provided.
S12rs Sgr No. 11 (Allergens), Westbrook
S12rs Sgr No. 11 (Allergens), Westbrook
Student Senate Enrolled Legislation
No abstract provided.
Post-Allergen Challenge Inhibition Of Poly(Adp-Ribose) Polymerase Harbors Therapeutic Potential For Treatment Of Allergic Airway Inflammation, A. S. Naura, C. P. Hans, M. Zerfaoui, D. You, S. A. Cormier, M. Oumouna, A. H. Boulares
Post-Allergen Challenge Inhibition Of Poly(Adp-Ribose) Polymerase Harbors Therapeutic Potential For Treatment Of Allergic Airway Inflammation, A. S. Naura, C. P. Hans, M. Zerfaoui, D. You, S. A. Cormier, M. Oumouna, A. H. Boulares
Faculty Publications
Background: Identifying therapeutic drugs that block the release or effects of T-helper type 2 (Th2) cytokines after allergen exposure is an important goal for the treatment of allergic inflammatory diseases including asthma. We recently showed, using a murine model of allergic airway inflammation, that poly(ADP-ribose) polymerase (PARP) plays an important role in the pathogenesis of asthma-related lung inflammation. PARP inhibition, by single injection of a novel inhibitor, thieno[2,3-c]isoquinolin-5-one (TIQ-A), before ovalbumin (OVA) challenge, prevented airway eosinophilia in C57BL/6 mice with concomitant suppression of Th2 cytokine production and mucus secretion. Objective: To evaluate the efficacy of the drug when it is …