Digital Commons Network^™

Irisin Protects Mitochondria Function During Pulmonary Ischemia/Reperfusion Injury, Ken Chen, Zaicheng Xu, Yukai Liu, Zhen Wang, Yu Li, Xuefei Xu, Caiyu Chen, Tianyang Xia, Qiao Liao, Yonggang Yao, Cindy Zeng, Duofen He, Yongjian Yang, Tao Tan, Jianxun Yi, Jingsong Zhou, Hua Zhu, Jianjie Ma, Chunyu Zeng

Faculty Publications

Limb remote ischemic preconditioning (RIPC) is an effective means of protection against ischemia/reperfusion (IR)-induced injury to multiple organs. Many studies are focused on identifying endocrine mechanisms that underlie the cross-talk between muscle and RIPC-mediated organ protection. We report that RIPC releases irisin, a myokine derived from the extracellular portion of fibronectin domain-containing 5 protein (FNDC5) in skeletal muscle, to protect against injury to the lung. Human patients with neonatal respiratory distress syndrome show reduced concentrations of irisin in the serum and increased irisin concentrations in the bronchoalveolar lavage fluid, suggesting transfer of irisin from circulation to the lung under physiologic …

Leveraging Partnerships And Collaboration To Advance Research: Kansas City Musculoskeletal Disease Consortium, Edward O'Connor, Robert A. White, William Duncan

Faculty Publications

No abstract provided.

Advancing Health Services Teams: Kcu Launches Only Clinical Psychology Program In The Two-State Region, Sarah E. Getch

Faculty Publications

No abstract provided.

How Kansas City University Is Creating A National Model For Student Wellness, Richard Winslow

Faculty Publications

No abstract provided.

Training Medical Scientists Of The Future, Robert A. White, Larry Segars, Marshall Andersen, Margaret Kincaid

Faculty Publications

No abstract provided.

Addressing Rural Health Challenges Head On, Marci Nielsen, Darrin D'Agostino, Paula Gregory

Faculty Publications

No abstract provided.

Innovations In Training The Next Generation Of Physicians For Missouri And The Nation, G. Michael Johnston

Faculty Publications

No abstract provided.

Flagship Program Provides A Model For Early Clinical Exposure, Service To Community, Ray Newman, Anne M. Vangarsse, Annette Campbell

Faculty Publications

No abstract provided.

System-Based Models Of Care Influencing Population Health Outcomes, Darrin D'Agostino

Faculty Publications

No abstract provided.

Kansas City University: A Private University With A Very Public Mission, Marc Hahn

Faculty Publications

No abstract provided.

Platelet Phosphorylated Tdp-43: An Exploratory Study For A Peripheral Surrogate Biomarker Development For Alzheimer's Disease, Rodger Wilhite, Jessica Sage, Abdurrahman Bouzid, Tyler Primavera, Abdulbaki Agbas

Faculty Publications

Aim: Alzheimer's disease (AD) and other forms of dementia create a noncurable disease population in world's societies. To develop a blood-based biomarker is important so that the remedial or disease-altering therapeutic intervention for AD patients would be available at the early stage.

Materials & methods: TDP-43 levels were analyzed in postmortem brain tissue and platelets of AD and control subjects.

Results: We observed an increased TDP-43 (<60%) in postmortem AD brain regions and similar trends were also observed in patient's platelets.

Conclusion: Platelet TDP-43 could be used as a surrogate biomarker that is measurable, reproducible and sensitive for screening the patients with some early clinical signs of AD and can be used to monitor …

Inhibition Of P70 S6 Kinase (S6k1) Activity By A77 1726, The Active Metabolite Of Leflunomide, Induces Autophagy Through Tak1-Mediated Ampk And Jnk Activation, Xiulong Xu, Jing Sun, Ruilong Song, Michelle E. Doscas, Ashley J. Williamson, Jingsong Zhou, Jun Sun, Xinan Jiao, Xiufan Liu, Yi Li

Faculty Publications

mTOR activation suppresses autophagy by phosphorylating ULK1 at S757 and suppressing its enzymatic activity. Here we report that feedback activation of mTOR in the PI-3 kinase pathway by two p70 S6 kinase (S6K1) inhibitors (PF-4708671 and A77 1726, the active metabolite of an immunosuppressive drug leflunomide) or by S6K1 knockdown did not suppress but rather induced autophagy. Suppression of S6K1 activity led to the phosphorylation and activation of AMPK, which then phosphorylated ULK1 at S555. While mTOR feedback activation led to increased phosphorylation of ULK1 at S757, this modification did not the disrupt ULK1-AMPK interaction nor dampen ULK1 S555 phosphorylation …

Absence Of Physiological Ca2+ Transients Is An Initial Trigger For Mitochondrial Dysfunction In Skeletal Muscle Following Denervation, Chehade Karam, Jianxun Yi, Yajuan Xiao, Kamal Dhakal, Lin Zhang, Xuejun Li, Carlo Manno, Jiejia Xu, Kaitao Li, Heping Cheng, Jianjie Ma, Jingsong Zhou

Faculty Publications

Background: Motor neurons control muscle contraction by initiating action potentials in muscle. Denervation of muscle from motor neurons leads to muscle atrophy, which is linked to mitochondrial dysfunction. It is known that denervation promotes mitochondrial reactive oxygen species (ROS) production in muscle, whereas the initial cause of mitochondrial ROS production in denervated muscle remains elusive. Since denervation isolates muscle from motor neurons and deprives it from any electric stimulation, no action potentials are initiated, and therefore, no physiological Ca2+ transients are generated inside denervated muscle fibers. We tested whether loss of physiological Ca2+ transients is an initial cause leading to …

Target Intestinal Microbiota To Alleviate Disease Progression In Amyotrophic Lateral Sclerosis, Yong-Guo Zhang, Shaoping Wu, Jianxun Yi, Yinglin Xia, Dapeng Jin, Jingsong Zhou, Jun Sun

Faculty Publications

Purpose: Emerging evidence has demonstrated that gut microbiome plays essential roles in the pathogenesis of human diseases in distal organs. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive loss of motor neurons. Treatment with the only drug approved by the US Food and Drug Administration for use in ALS, riluzole, extends a patient׳s life span by only a few months. Thus, there is an urgent need to develop novel interventions that for alleviate disease progression and improve quality of life in patients with ALS. Here we present evidence that intestinal dysfunction and dysbiosis may actively …

The Biomechanics Of Bony Facial "Buttresses" In South African Australopiths: An Experimental Study Using Finite Element Analysis, Justin A. Ledogar, Stefano Benazzi, Amanda L. Smith, Gerhard W. Weber, Keely B. Carlson, Paul C. Dechow, Ian R. Grosse, Callum F. Ross, Brian G. Richmond, Barth Wright, Qian Wang, Craig Byron, Kristian J. Carlson, Darryl J. De Ruiter, Leslie C. Pryor Mcintosh, David S. Strait

Faculty Publications

Australopiths exhibit a number of derived facial features that are thought to strengthen the face against high and/or repetitive loads associated with a diet that included mechanically challenging foods. Here, we use finite element analysis (FEA) to test hypotheses related to the purported strengthening role of the zygomatic root and "anterior pillar" in australopiths. We modified our previously constructed models of Sts 5 (Australopithecus africanus) and MH1 (A. sediba) to differ in the morphology of the zygomatic root, including changes to both the shape and positioning of the zygomatic root complex, in addition to creating variants of Sts 5 lacking …

Ivv-13 Beneficial Effect Of Oxaloacetate For The Neuromuscular Function Of Sod1g93a Mice, Hiroshi Nishimune, Sudheer K. Tungtur, Heather M. Wilkins, Russell H. Swerdlow, Jessica Sage, Abdulbaki Agbas, Richard J. Barohn

Faculty Publications

Introduction and aims: The etiology of ALS remains unknown despite the identification of mutated genes in familial and/or sporadic ALS. It is thought that aggregates of disease-causing mutant proteins and RNAs disrupt the normal cellular functions that leads to dying back neuropathy and motor neuron degeneration. Mitochondrial dysfunction is thought to play a major role in the pathology of ALS (1–3). Therefore, restoration of mitochondrial function is likely to cause beneficial effects for the survival of ALS model mice (4).

The objective of this project is to evaluate the effects of oxaloacetate for the neuromuscular function and lifespan of the …