Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Entire DC Network
Predicting Modes Of Toxic Action From Chemical Structure: Acute Toxicity In The Fathead Minnow (Pimephales Promelas), Steven P. Bradbury, Christine L. Russom, Steven J. Broderius, Dean E. Hammermeister, Robert A. Drummond
Predicting Modes Of Toxic Action From Chemical Structure: Acute Toxicity In The Fathead Minnow (Pimephales Promelas), Steven P. Bradbury, Christine L. Russom, Steven J. Broderius, Dean E. Hammermeister, Robert A. Drummond
Steven P. Bradbury
In the field of aquatic toxicology, quantitative structure-activity relationships (QSARs) have developed as scientifically credible models for predicting the toxicity of chemicals when little or no empirical data are available. In recent years, there has been an evolution of QSAR development and application from that of a chemical-class perspective to one that is more consistent with assumptions regarding modes of toxic action. The objective of this research was to develop procedures that relate modes of acute toxic action in the fathead minnow (Pimephales promelas) to chemical structures and properties. An empirically derived database for diverse chemical structures of acute toxicity …