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Enhanced Adhesion Of Pasteurella Multocida To Cultured Turkey Peripheral Blood Monocytes, Ingrid M. Pruimbroom, Richard B. Rimler, Mark R. Ackermann
Enhanced Adhesion Of Pasteurella Multocida To Cultured Turkey Peripheral Blood Monocytes, Ingrid M. Pruimbroom, Richard B. Rimler, Mark R. Ackermann
Mark R. Ackermann
Capsular hyaluronic acid (HA) mediates adhesion of serogroup A strains of Pasteurella multocida to elicited turkey air sac macrophages (TASM). In contrast, freshly isolated turkey peripheral blood monocytes (TPBM) do not bind serogroup A strains. Following culture of TPBM for 6 days in chamber slides, adhesion of the bacteria to TPBM increased gradually. Incubation in chamber slides coated with entactin-collagen IV-laminin (ECL) attachment matrix or exposure to phorbol myristate acetate (PMA) further enhanced the adhesion ofP. multocida to TPBM. Addition of HA, but not Arg-Gly-Asp peptide, to TPBM culture inhibited bacterial adherence similarly to the inhibition previously reported for TASM. …