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Invasion Of Caco-2 Cells By Salmonella Typhimurium (Copenhagen) Isolates From Healthy And Sick Chickens, Theodore J. Kottom, Lisa K. Nolan, John Brown
Invasion Of Caco-2 Cells By Salmonella Typhimurium (Copenhagen) Isolates From Healthy And Sick Chickens, Theodore J. Kottom, Lisa K. Nolan, John Brown
Lisa K. Nolan
In a previous study, Salmonella isolates of sick birds were distinguished from those of apparently healthy birds by their high degree of invasion of tissue culture cells. In this study, a single pair of Salmonella isolates was examined to determine the source of this observed difference in invasion. When isolates were allowed to invade Caco-2 cells for 8 hours, the isolate from the sick bird (S) appeared to invade in greater numbers than did the isolate from the healthy bird (H). However, when invasion was distinguished from intracellular growth/survival, it was found that H invaded in greater numbers than S, …