Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Entire DC Network
Design And Synthesis Of Small-Molecule Inhibitors Of The Hypoxia Inducible Factor-1 As Anticancer Therapeutics, Zeus Allen O. De Los Santos
Design And Synthesis Of Small-Molecule Inhibitors Of The Hypoxia Inducible Factor-1 As Anticancer Therapeutics, Zeus Allen O. De Los Santos
Chemistry Theses
Throughout history, cancer has been severely plaguing mankind; the search for a
cure to cancer had long been sought by scientists and still poses as one of the
greatest challenges scientists have yet to overcome. Hypoxia in cells is a condition
where there is little to no oxygen availability in its environment. In general, this event
is detrimental since this can lead to cell necrosis or reoxygenation injuries. However,
hypoxia, a prominent property of most solid tumors, activates the hypoxia-inducible
factor (HIF-1) family of transcription factors that promotes angiogenesis. In this
study, we describe the design and synthesis of small-molecule …
An Assessment Of Selected Factors Associated With Hpv Vaccination Completion Among The African American Adolescents In United States: 2012 National Immunization Survey - Teen, Vaishali Sahu
Public Health Theses
Background: Human Papillomavirus is the most common STI in United States and is most prevalent among the adolescents and young adults. HPV causes cervical, anal, vulvar, vaginal, penile, oropharyngeal cancers and ano-genital warts. Certain populations are found to be at higher risk such as African Americans. 3 doses of HPV vaccine are recommended to adolescents before sexual debut to immunize against HPV. The purpose of this study was to assess the factors associated with the completion of 3 dose HPV vaccination series particularly among the African American adolescents.
Methods: National Immunization Survey – Teen 2012 data was used to assess …
Extracellular Pyruvate Kinase M2 Regulates Tumor Angiogenesis, Liangwei Li
Extracellular Pyruvate Kinase M2 Regulates Tumor Angiogenesis, Liangwei Li
Biology Dissertations
Pyruvate kinase M2 (PKM2) has been studied for decades on its role in cancer metabolism. Recently, PKM2 is highlighted again for its new function: promoting gene transcription by acting as a protein kinase. Moreover, the PKM2 levels in patient circulation have been used as a diagnostic marker for many types of cancers. However, it remains unclear whether PKM2 in blood circulation has any physiological or pathological function. In my dissertation, I demonstrate that PKM2 released from cancer cells facilitates tumor growth by promoting tumor angiogenesis. Our experiments show that PKM2 promotes endothelial cell proliferation, migration and survival. Only the dimeric …