Digital Commons Network^™

Estrogen-Induced Dna Synthesis In Vascular Endothelial Cells Is Mediated By Ros Signaling, Quentin Felty

Environmental Health Sciences

Since estrogen is known to increase vascular endothelial cell growth, elevated estrogen exposure from hormone replacement therapy or oral contraceptives has the potential to contribute in the development of abnormal proliferative vascular lesions and subsequent thickening of the vasculature. How estrogen may support or promote vascular lesions is not clear. We have examined in this study whether estrogen exposure to vascular endothelial cells increase the formation of reactive oxygen species (ROS), and estrogen-induced ROS is involved in the growth of endothelial cells.

METHODS:

The effect of estrogen on the production of intracellular oxidants and the role of estrogen-induced ROS on …