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Isolation And Structural Determination Of Bioactive Metabolites Produced By A Soil Bacterium, Arthrobacter Sp. Tajx1902, Amonah Arije, Andy Agbakpo, Sean James Fox, Abbas Shilabin
Isolation And Structural Determination Of Bioactive Metabolites Produced By A Soil Bacterium, Arthrobacter Sp. Tajx1902, Amonah Arije, Andy Agbakpo, Sean James Fox, Abbas Shilabin
Appalachian Student Research Forum
As antimicrobial resistance persistently disrupts the treatment of microbial infection, identifying novel drugs with novel modes of action is critical to getting ahead of resistance. The primary goal of this project is to extract and identify novel chemical products produced by Arthrobacter sp. TAJX1902, particularly antimicrobial metabolites. Although underexplored, Arthrobacter sps. have been shown to produce bioactive compounds of great versatility; one such is a depsipeptide with quorum-sensing inhibitory activity.1 In this research, Arthrobacter sp. TAJX1902 isolated from a soil sample showed inhibitory activity against a filamentous indicator-type bacterium and a violacein-producing Janthinobacterium sp. A. sp. TAJX1902 was cultured using …
A New All-Natural Wound Treatment Gel Shows Strong Inhibitory Activity Against Staphylococcus Aureus And Other Wound Pathogens, Tasha K. Nelson
A New All-Natural Wound Treatment Gel Shows Strong Inhibitory Activity Against Staphylococcus Aureus And Other Wound Pathogens, Tasha K. Nelson
Electronic Theses and Dissertations
Skin related injuries are some of the most dangerous forms of wounds. In addition to treating the wound itself, health care providers must be cautious of microbial infections. In this study, we evaluate a novel all-natural antimicrobial gel compound (AMG) designed to kill planktonic bacteria, penetrate bacterial biofilms, and accelerate wound healing. In -vitro experiments demonstrate that AMG is effective in inhibiting planktonic growth and biofilm development of eight common pathogens. LIVE/DEAD staining and confocal microscopy reveal that planktonic growth and three-dimensional structure of biofilms were significantly reduced. Reverse Transcriptase Polymerase Chain Reaction (RT-PCR) was used to investigate a small …
Discovery And Characterization Of An Antibiotic From The Soil Bacterium Bacillus Sp., Thomas S. Barber
Discovery And Characterization Of An Antibiotic From The Soil Bacterium Bacillus Sp., Thomas S. Barber
Electronic Theses and Dissertations
Many important antibiotics have become nearly obsolete due to the rise of antibiotic resistant pathogens. Rhodococcus, an actinomycete related to the prolific antibiotic producing genus Streptomyces, harbors over 30 genes for secondary metabolism that could be involved in antibiotic production. Several antibiotics have already been reported for Rhodococcus, suggesting the genus may be a good source for new inhibitory compounds. Fifty four soil bacteria were isolated using enrichment culture techniques (including 37 Rhodococcus) and screened for antibiotic producers. BTHX2, a species of Bacillus was found to have activity against Micrococcus luteus and Rhodococcus erythropolis. BTHX2 …