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Perceptions Of Risk For Covid-19 Among Individuals With Chronic Diseases And Stakeholders In Central Appalachia, Manik Ahuja, Hadii M. Mamudu, Florence M. Weierbach, Karilynn Dowling-Mcclay, David W. Stewart, Manul Awasthi, Timir K. Paul Dec 2021

Perceptions Of Risk For Covid-19 Among Individuals With Chronic Diseases And Stakeholders In Central Appalachia, Manik Ahuja, Hadii M. Mamudu, Florence M. Weierbach, Karilynn Dowling-Mcclay, David W. Stewart, Manul Awasthi, Timir K. Paul

ETSU Faculty Works

Coronavirus disease 2019 (COVID-19) pandemic is rapidly evolving and is a serious public health threat worldwide. Timely and effective control of the pandemic is highly dependent on preventive approaches. Perception of risk is a major determinant of health behavior. The current study explores the association between actual risk and perceived risk for one’s self, family/friends and friends, and community. A questionnaire was administered to participants in Central Appalachia (n = 102). The actual risk was based on the number of chronic conditions of the following conditions: hypertension, heart disease, cancer, diabetes, and chronic obstructive pulmonary disease. Participants were also queried …


Blockade Of Sars-Cov-2 Spike Protein-Mediated Cell–Cell Fusion Using Covid-19 Convalescent Plasma, Ling Wang, Juan Zhao, Lam N.T. Nguyen, Lam N.T. Nguyen, James L. Adkins, Madison Schank, Sushant Khanal, Xindi Dang, Dechao Cao, Bal K. C. Thakuri, Zeyuan Lu, Jinyu Zhang, Yi Zhang, Xiao Y. Wu, Mohamed El Gazzar, Shunbin Ning, Jonathan P. Moorman, Zhi Q. Yao Dec 2021

Blockade Of Sars-Cov-2 Spike Protein-Mediated Cell–Cell Fusion Using Covid-19 Convalescent Plasma, Ling Wang, Juan Zhao, Lam N.T. Nguyen, Lam N.T. Nguyen, James L. Adkins, Madison Schank, Sushant Khanal, Xindi Dang, Dechao Cao, Bal K. C. Thakuri, Zeyuan Lu, Jinyu Zhang, Yi Zhang, Xiao Y. Wu, Mohamed El Gazzar, Shunbin Ning, Jonathan P. Moorman, Zhi Q. Yao

ETSU Faculty Works

The recent COVID-19 pandemic poses a serious threat to global public health, thus there is an urgent need to define the molecular mechanisms involved in SARS-CoV-2 spike (S) protein-mediated virus entry that is essential for preventing and/or treating this emerging infectious disease. In this study, we examined the blocking activity of human COVID-19 convalescent plasma by cell–cell fusion assays using SARS-CoV-2-S-transfected 293 T as effector cells and ACE2-expressing 293 T as target cells. We demonstrate that the SARS-CoV-2 S protein exhibits a very high capacity for membrane fusion and is efficient in mediating virus fusion and entry into target cells. …


Psychological Distress And Susceptibility To Disease In The Infant And Early Childhood Mental Health (Iecmh) Workforce In The Time Of The Covid-19 Pandemic, Ashley Sexton May 2021

Psychological Distress And Susceptibility To Disease In The Infant And Early Childhood Mental Health (Iecmh) Workforce In The Time Of The Covid-19 Pandemic, Ashley Sexton

Undergraduate Honors Theses

Chronic stress, anxiety, and depression can have many adverse effects on physical health, including immunosuppression and increased susceptibility to disease. For the last year, the world has endured sustained stress caused by the COVID-19 pandemic which has had its own impact on mental health. Stress from COVID-19 will likely have an even greater impact on the Infant and Early Childhood Mental Health (IECMH) workforce due to the stressful nature of their work. Self-care has been shown to improve overall wellbeing and act as a buffer for stress. Therefore, the current study aims to investigate if IECMH workers with clinically significant …


“We’Re Sinking And We’Re Sinking Quick”: Family And Feeding Work During The Covid-19 Pandemic For Single, White, Middle-Class Mothers, Debora Garrison May 2021

“We’Re Sinking And We’Re Sinking Quick”: Family And Feeding Work During The Covid-19 Pandemic For Single, White, Middle-Class Mothers, Debora Garrison

Electronic Theses and Dissertations

This study examines the work of single, white, middle-class women feeding and caring for their families during the COVID-19 pandemic in the year 2020. The study draws from qualitative analyses of one-on-one interviews conducted with seven single mothers. After situating single mothers and family food provision in the academic literature, as well as and current knowledge about the pandemic in the U.S., the author explores ways that the pandemic disrupted family life. Findings indicated that the single mothers were keenly impacted by being cut off from child care, schools, and other social connections they needed to maintain employment. Further, their …


Sororities Surviving Covid-19: A Phenomenological Study Of Panhellenic Virtual Sorority Recruitment, Margaret Darden May 2021

Sororities Surviving Covid-19: A Phenomenological Study Of Panhellenic Virtual Sorority Recruitment, Margaret Darden

Electronic Theses and Dissertations

This phenomenological study addressed perceptions of virtual sorority recruitment and was conducted at a large, public university in the Midwestern United States. Data was gathered through interviews using a criterion sampling method in place for this study. Study participants fell into one of the following categories: new members, general members, chapter recruitment chairs, chapter presidents, chapter advisors, chapter recruitment advisors, or the fraternity/sorority advisor. Emerging themes and categories were identified by coding and analyzing the interview data. The themes that were identified were: the convenience of online meetings, reduced emphasis on appearance reduced emotional, financial and time strain, increased accessibility …


Preserving Safety While Upholding The Integrity Of Medical Education And Practical Skills: The Impact Of Covid-19 On Teaching Human Anatomy, Anna Cowan May 2021

Preserving Safety While Upholding The Integrity Of Medical Education And Practical Skills: The Impact Of Covid-19 On Teaching Human Anatomy, Anna Cowan

Undergraduate Honors Theses

The global pandemic caused by COVID-19 placed constraints on several aspects of normal life, especially those of higher level education. While many programs moved to teaching in a strictly online format, there are some courses in which this structure was not appropriate. This study observed the outcome of the adapted course structure employed at Quillen College of Medicine during their Gross Human Anatomy course. Through a voluntary survey and multiple independent t-tests, it was demonstrated that the students who took the adapted course performed, on average, 2 points lower on each exam than previous classes. Also, this study showed that …


Symptoms-Based Fuzzy-Logic Approach For Covid-19 Diagnosis, Maad Shatnawi, Anas Shatnawi, Zakarea Alshara, Ghaith Husari Jan 2021

Symptoms-Based Fuzzy-Logic Approach For Covid-19 Diagnosis, Maad Shatnawi, Anas Shatnawi, Zakarea Alshara, Ghaith Husari

ETSU Faculty Works

The coronavirus (COVID-19) pandemic has caused severe adverse effects on the human life and the global economy affecting all communities and individuals due to its rapid spreading, increase in the number of affected cases and creating severe health issues and death cases worldwide. Since no particular treatment has been acknowledged so far for this disease, prompt detection of COVID-19 is essential to control and halt its chain. In this paper, we introduce an intelligent fuzzy inference system for the primary diagnosis of COVID-19. The system infers the likelihood level of COVID-19 infection based on the symptoms that appear on the …


Hydroxychloroquine: A Comprehensive Review And Its Controversial Role In Coronavirus Disease 2019, Pankaj Bansal, Amandeep Goyal, Austin Cusick, Shubham Lahan, Harpal S. Dhaliwal, Poonam Bhyan, Pradnya B. Bhattad, Fawad Aslam, Sagar Ranka, Tarun Dalia, Lovely Chhabra, Devang Sanghavi, Bhavin Sonani, John M. Davis Jan 2021

Hydroxychloroquine: A Comprehensive Review And Its Controversial Role In Coronavirus Disease 2019, Pankaj Bansal, Amandeep Goyal, Austin Cusick, Shubham Lahan, Harpal S. Dhaliwal, Poonam Bhyan, Pradnya B. Bhattad, Fawad Aslam, Sagar Ranka, Tarun Dalia, Lovely Chhabra, Devang Sanghavi, Bhavin Sonani, John M. Davis

ETSU Faculty Works

Hydroxychloroquine, initially used as an antimalarial, is used as an immunomodulatory and anti-inflammatory agent for the management of autoimmune and rheumatic diseases such as systemic lupus erythematosus. Lately, there has been interest in its potential efficacy against severe acute respiratory syndrome coronavirus 2, with several speculated mechanisms. The purpose of this review is to elaborate on the mechanisms surrounding hydroxychloroquine. The review is an in-depth analysis of the antimalarial, immunomodulatory, and antiviral mechanisms of hydroxychloroquine, with detailed and novel pictorial explanations. The mechanisms of hydroxychloroquine are related to potential cardiotoxic manifestations and demonstrate potential adverse effects when used for coronavirus …