Digital Commons Network^™

Nicotine Sensitization And Brain-Derived Neurotrophic Factor Content In Adolescent Rats Neonatally Treated With Quinpirole., Addie Roberts

Undergraduate Honors Theses

Neonatal treatment of quinpirole in rats increases dopamine D2-like receptor sensitivity over the animal’s lifetime, a phenomenon referred to as D2 priming. Male and female Sprague-Dawley rats were given quinpirole (1mg/kg, i.p.) or saline on postnatal days (P)1-21. After habituation to a locomotor arena on P29-31, beginning P33, animals were administered nicotine (0.3 mg/kg, 0.5 mg/kg, or 0.7 mg/kg, i.p.) or saline and placed into a locomotor arena for behavioral testing every second day for a total of 9 treatments. The results showed that adolescents neonatally treated with quinpirole produced more enhanced sensitization to nicotine than controls. Brains tissues were …

Confessions: A Bfa Exhibition., Mary Carolyn Molony

Undergraduate Honors Theses

The artist discusses her Bachelor of Fine Arts Exhibition, Confessions, held at the Tipton Gallery, from November 14th to November 25th. The exhibit portrays how the artist responds to issues such as organized religion, war, and politics. Being drawn to art from the Renaissance to Baroque era, the work encorporates an "old world" aesthetic, also with an emphasis on Gothic architecture.

Marry The Night: Creation Of An Illustrated Novel., Kristen Hawkins

Undergraduate Honors Theses

The goal of this project was to create an illustrated story. The thesis is combination of research both on narrative theory and the process of storytelling, and different methods of narrative art. The research information obtained was used to create a body of work which was later analyzed on its successfulness at adhering to the ideas presented by the research.

Brain-Derived Neurotrophic Factor Levels In D2 Receptor Primed Adolescent Rats Given Twice Daily Nicotine Administrations., Josie Minnigh

Undergraduate Honors Theses

Nicotine use is very prevalent in the schizophrenic population, which is a 2.5 fold greater than the general population. In the present study, the drug quinpirole (dopamine D2/D3 agonist) or saline was given neonatally to 25 Sprague-Dawley male and female rats. Rats were randomly assigned to condition. Beginning postnatal day 33 animals were given twice daily administrations of nicotine (0.5 mg/kg free base). After the first of the daily injections they were placed in a locomotor arena every other day for behavioral testing. One day after behavioral testing, the dorsal striatum and nucleus accumbens were removed for brain-derived neurotrophic factor …

The Effects Of Negative Publicity On The Performance Of Professional Baseball Athletes., Crystal M. Smallwood

Undergraduate Honors Theses

This study researched the effects of negative publicity on the performance of professional baseball athletes. Four athletes’ performance statistics were evaluated before a scandal that produced negative publicity, during the height of the negative publicity and after the scrutiny tapered off. Chipper Jones, Wade Boggs, Alex Rodriguez and David Justice were the athletes chosen for the study, and all four athletes experienced a similar scandal and negative publicity about their personal and professional lives. The results showed an effect on performance, but it was not always negative and could not be definitively linked to the negative exposure in the media. …

Elementary School Teachers Perceptions Of Effective Leadership Practices Of Female Principals., Jennifer Anne Mooney

Electronic Theses and Dissertations

The problem of this qualitative study is to assess teacher perceptions of the leadership practices of female principals. The focus of this study was at the elementary school level. The data were collected from the teachers about their perceptions regarding the female principals with whom they work. This qualitative study was conducted by interviewing 8 teachers from 3 elementary schools in northeast Tennessee. The teachers were interviewed to understand their perceptions of effective leadership practices exhibited by female principals.

During the data analysis, 7 constructs were identified after examining and coding the data for related themes. These 7 constructs were: …

Synthesis Of Chemical Models Of Hydrolase Enzymes For Intramolecular Catalysis., Cornelius Ndi Ndi

Electronic Theses and Dissertations

Most nuclease enzymes can hydrolyze phosphoester bonds (in DNA and RNA) by using metal ions cofactors that coordinate and activate water molecules in the enzymes' active sites. However, there are some hydrolase enzymes (including nucleases) that can function without the aid of metal ions. 2,6-Di(1H-imidazol-2-yl)phenol, a model compound for hydrolase enzyme, was synthesized by the reaction between ethylenediamine and dimethyl-3-carboxysalicylate, initially resulting in the formation of diimidazoline. The diimidazoline was subsequently aromatized to the diimidazole by dehydrogenation over palladium. The overall reaction yield was low; therefore, other dehydrogenation transformation reactions were tried but all failed to improve the …

Neither A Borrower Nor A Lender Be: America Attempts To Collect Its War Debts 1922-1934., James Chambers

Electronic Theses and Dissertations

During and immediately after World War I the United States lent over $10 billion to various countries to sustain their war efforts and to provide post-war relief. The United States's insistence that these loans be repaid led to sharp disagreements with its erstwhile allies as to the nature of these loans and whether they should actually be repaid.

This thesis examines the processes, and the policies upon which those processes were based, by which the United States attempted to compel the debtor nations to begin repaying their loans.

The central theme of the thesis was developed largely from primary sources, …

Entry Age And Reading Level By The End Of Third Grade., Tony Lynn Dalton

Electronic Theses and Dissertations

This study was conducted to see if a difference exists in the mean Dynamic Indicators of Basic Early Literacy Skills: Oral Reading Fluency scores of students who entered kindergarten as 4 year olds, 5 year olds, and 6 year olds inclusively. Specifically, this dissertation considered the possibility that holding children out of kindergarten an extra year increased their reading level, while sending children to school too young delayed their ability to read and comprehend.

A quantitative study was used to find differences between the mean reading levels at the end of 3rd grade for students who entered kindergarten on or …

Common Characteristics Of School Administrators Who Are Perceived As Effective In Meeting The Needs Of Students With Disabilities., Carissa Gail Mitchell

Electronic Theses and Dissertations

This qualitative study was conducted in 3 school systems in East Tennessee by interviewing special education directors, school principals, and teachers. The purpose of this study was to identify administrators who are successful in meeting the needs of special education students and determine characteristics they possess that facilitate success. The grounded theory study employed purposeful sampling and the snowball sampling method. It also included the use of a pilot study to refine the interview protocol. This study includes the characteristics of effective principals as perceived by the special education directors, principals, and teachers. Although some variety of conclusions existed within …

Student Outcomes And The Implementation Of A Ninth Grade Academy In A Western North Carolina High School., Monet Calloway Samuelson

Electronic Theses and Dissertations

One purpose of this study was to compare outcomes of students who were part of a 9^th grade academy during their freshman year with outcomes of students who were not part of a 9^th grade academy during their freshman year. Student outcomes are defined for this study to include attendance, promotion rate to 10^th grade on time, in-school suspension assignments, Algebra I End-of-Course exam scores, and English I End-of-Course exam scores. The second purpose of this study was to compare outcomes of 10^th grade students who were part of a 9^th grade academy during their …

Perspectives Of Special Education Teachers On Implementation Of Inclusion In Four High Schools In East Tennessee., Lori Bellar Goodin

Electronic Theses and Dissertations

The terminology found in state educational policies coupled with congressional intent provides a supportive framework for integration of inclusion into public education (Duhaney, 1999; Heumann, 1994). The U.S. Department of Education declared that the required continuum of alternative placements reinforces the importance of the consideration of the individual versus programming for the masses in determining what placement is the LRE for each student with a disability (Heumann, 1994). This disagreement of what constitutes the best educational model affects political agendas and funding issues (Idol, 2006).

The purpose of this study was to examine special education teacher perceptions through a qualitative …

Modified Organoclay Containing Chelating Ligand For Adsorption Of Heavy Metals In Solution., Mary Akuyea Addy

Electronic Theses and Dissertations

Presence of a chelating ligand in the clay structure significantly improves its ability to immobilize heavy metals from contaminated sludge or wastewater. Two-step modification procedure comprising sequential pillaring and grafting of chelating agent to the modified clay is involved.

Montmorillonite and kaolin were chosen as typical examples of expandable and non-expandable clays, correspondingly. Modifications with silica and ferric oxide were targeted on development of mesoporous structure. Laboratory tests of the organoclay efficiency for purification of wastewater were conducted with the most promising sample, i.e. organoclay with the highest specific loading of chelating agent. Experiments were conducted with model wastewater containing …

Using Electrochemical Method To Study The Interaction Between Dna And A Compound Known To Have Anticancer Property., Alexander Kamasah

Electronic Theses and Dissertations

The interaction of 4-(1'-[8'-(1''-pyrenyl)naphthyl])-2,6-diaminopyridine bis-glycamide bishydrocholride known to have anticancer properties with deoxyribonucleic acid (DNA) had been studied on a modified gold electrode by self-assembled monolayer using cyclic voltammetry. K₄Fe (CN)₆ was used as a probe to obtain electrochemical information on the electrode surface.

A bare gold (Au) electrode was modified with cysteamine and our results showed no change in the limiting steady state current as compared to the bare Au electrode. There was a reduction in the steady state current after the modification of the gold electrode with DNA. Immobilization of the DNA modified gold electrode …

A Content Analysis Of Reliability In Advertising Content Analysis Studies., Weize Wang

Electronic Theses and Dissertations

Content analysis is a systematic research method for examining symbolical content in communication by recording or transcribing these messages into categories. Reliability is one of the most distinctive attributes of content analysis methodology comparing to other techniques in communication. A content analysis was conducted by analyzing the method sections of published journal articles in Communication Abstracts from January 2006 through January 2011 by searching "advertising" and "content analysis". Results suggested that television is still the most focused medium in advertising content analysis research. Most of the content analysis studies employed 2 coders for coding reliability assessment data and final data. …

An Investigation Of Reading Instruction In Northeast Tennessee., Karen Pierson Reach

Electronic Theses and Dissertations

The purpose of this qualitative study was to examine specific prekindergarten- through 8th-grade reading programs, instructional best practices, academic interventions, and educational activities that are perceived as successful practices in four high achieving schools within the parameters of Northeast Tennessee. This study was accomplished through a protocol of open-ended interviews with 15 participants comprised of 4 school principals, 4 primary reading teachers, 4 intermediate reading teachers, 2 Title I reading specialists, and 1 district language arts coordinator. Additionally, school-specific documentation and basal reading programs were reviewed to triangulate the findings of this investigation.

The findings from this study suggested that …

Fabrication Of Chemically Modified Nanometer-Sized Gold Electrodes And Their Application In Electrocatalysis At Pt Nanoparticles., Jude Lakbub

Electronic Theses and Dissertations

Hydrogen evolution via proton reduction occurs at a high rate at the surface of Pt than at Au electrodes. Using cyclic voltammetry, chemically modified nanometer-sized Au electrodes, prepared by the Laser-Assisted Puller Method, were employed to examine current amplification by electrocalysis at Pt nanoparticles adsorbed on the modified Au electrode surfaces. The electrodes were modified with Self-Assembled Monolayers (SAMs) of cysteamine and soaked in Pt colloid solutions overnight. Monitoring the decrements of the characteristic steady-state catalytic current for proton reduction indicated that aggregates of Pt nanoparticles are adsorbed on the cysteamine monolayers and desorb from them particle by particle. The …

From Confederate Deserter To Decorated Veteran Bible Scholar: Exploring The Enigmatic Life Of C.I. Scofield 1861-1921., D. Jean Rushing

Electronic Theses and Dissertations

Cyrus Ingerson Scofield portrayed himself as a decorated Confederate veteran, a successful lawyer, and a Bible scholar who was providentially destined to edit his 1909 dispensational opus, The Scofield Reference Bible. This thesis offers a multilayered image of Dr. Scofield's life by considering political and regional influences, racial and gender attitudes, and religious views he encountered between 1861 and 1921. This study includes an examination of his participation in the American Civil War including his desertion of the South in 1862. After becoming a Union loyalist, Scofield excelled as a lawyer and Republican politician before corruption rumors radically altered …

A Study Of The Effects Of Titanium Dioxide Nanoparticles On The Fluorescent Intensity Of Fluorescent Compounds In The Presence Of Known Quenchers., Vivian Dzigbodi Koka

Electronic Theses and Dissertations

Titanium Dioxide is a naturally occurring oxide of titanium. It has a wide range of uses in commercial products for providing whiteness and opacity. It has photocatalytic properties and can also be used to produce electricity in its nanoparticles form. This research is focused on investigating the effect of titanium dioxide nanoparticles in analysis of compounds using luminescence-based techniques. Quenching, which is one of the basic problems of fluorescent measurements, was studied in the presence of molecular oxygen and methyl iodide. The rutile phase of titanium dioxide nanoparticles was synthesized by the acid hydrolysis of titanium isobutoxide at low temperatures …

The Development And Fabrication Of A Modular Vertical Reciprocating Conveyor System For The Transportation Of Materials To And From A Mezzanine., Matthew Paul Crum

Electronic Theses and Dissertations

The purpose of this developmental project was to design and fabricate a vertical reciprocating conveyor in order to eliminate the process of manually carrying 27 pound containers of plastic resin up and down a flight of offset space saver stairs. This project took place and was built for Phoenix Closures Incorporated. The conveyor was designed and built in house because there are no commercially available vertical reciprocating conveyors available that meet the necessary requirements.

The capabilities of the proposed vertical reciprocating conveyor are not limited to the carrying of the containers but designed to carry vacuum cleaners, tool boxes, and …

Military Women A Content Analysis Of United States And United Kingdom Newspapers Portrayal During The Iraq War., Audra Jaclyn Fritz

Electronic Theses and Dissertations

The purpose of this study was to determine how the tone and roles of women serving in the Iraq War were portrayed in newspaper articles. Issues of how women in the military were portrayed in terms of page and story prominence were also of importance.

A content analysis was conducted in order to determine the tone, roles, story, and page placement of newspaper articles published in the United States and the United Kingdom over a 7-year time period. Newspaper articles related to the topic were retrieved from the LexisNexis database and analyzed.

The results showed that mentions of military women …

Isolation Of A Rhodococcus Soil Bacterium That Produces A Strong Antibacterial Compound., Ralitsa Bogomilova Borisova

Electronic Theses and Dissertations

Rhodococci are notable for their ability to degrade a variety of natural and xenobiotic compounds. Recently, interest in Rhodococcus has increased due to the discovery of a large number of genes for secondary metabolism. Only a few secondary metabolites have been characterized from the rhodococci (including 3 recently described antibiotics). Twenty-four new Rhodococcus strains were isolated from soils in East Tennessee using acetonitrile enrichment culturing and identified using 16S rRNA analysis. Forty-seven Rhodococcus strains were screened for antibiotic production using a growth inhibition assay. One strain, MTM3W5.2, had 90% similarity to the Rhodococcus opacus 16S rRNA gene sequence and produced …

On The Imperishable Face Of Granite: Civil War Monuments And The Evolution Of Historical Memory In East Tennessee 1878-1931., Kelli Brooke Nelson

Electronic Theses and Dissertations

After the Civil War individuals throughout the country erected monuments dedicated to the soldiers and events of the conflict. In East Tennessee these memorials allowed some citizens to promote their ideas by invoking both Union and Confederate Civil War sympathies. Initially, East Tennesseans endorsed the creation of a Unionist image to advertise the region's potential for industrialization. By 1910 this depiction waned as local and northern whites joined to promote reconciliation and Confederate sympathizers met less opposition to their ideas than in the past. After 1919 white East Tennesseans, enmeshed in the boom and bust cycles of the national economy, …

The Digital Folklore Project: Tracking The Oral Tradition On The World Wide Web., Jasen Bacon

Electronic Theses and Dissertations

I collected forty-two e-mail forwards over the course of four months, and from those I formulated a framework that adapts existing theory in collection and study of real-world folklore to the emerging folk communities that exist on the internet. Through this analysis I prove that the same genres of folklore that is routinely collected by folklorists have been adapted to fit the digital environment of the internet. I then use the framework that I lay out to perform a study of the e-mails themselves.

Synthesis Of Resveratrol Ester Derivatives Using Selective Enzymatic Hydrolysis., Marian Osei-Mensah

Electronic Theses and Dissertations

Resveratrol, a naturally derived stilbene, is an interesting compound mostly talked about recently because for its anti-cancer properties. Unfortunately it has some shortcomings due to its low bioavailability and low solubility in water. For this reason, my research is to overcome resveratrol's drawbacks by improving its bioavailability and hydrophilicity. My research is focused on syntheses of novel derivatives of resveratrol such as 3, 5-di-O-isobutyroyl resveratrol and 3, 5-di-O-hexanoyl resveratrol using lipase catalyzed hydrolysis. Therefore, the tri-acylated resveratrols 3, 5, 4'-tri-O-isobutyroyl resveratrol and 3, 5,4'-tri-O-hexanoyl resveratrol were first synthesized.

3,5,4'-tri-O-isobutyroyl resveratrol and 3,5,4'-tri-O-hexanoyl resveratrol were then hydrolyzed using lipase (C. …

Free Clinics And The Uninsured: The Need For Remote Area Medical In Central Appalachia After Health Reform., James W. Watson

Electronic Theses and Dissertations

In 2008, the election of President Barack Obama brought health care to the forefront of national discussions and led to the passage of the Patient Protection and Affordable Care Act (ACA). The legislation changed the rules of health care delivery in the United States, but the ACA did not do one fundamental thing: It did not end the need for many of the nation's most needy patients to seek free medical care from groups such as Remote Area Medical (RAM).

A mobile clinic, RAM brings together volunteer dentists, physicians, nurses, and other professionals as well as support staff for multi-day …

Use Of Isometric Mid-Thigh Pull To Determine Asymmetrical Strength Differences In Ncaa D-I Athletes., Ethan Monroe Owens

Electronic Theses and Dissertations

The purpose of this study is to investigate the use of isometric mid-thigh pulls to determine lower-limb asymmetrical strength differences in NCAA D-I athletes. Sixty-six subjects (40 males and 26 females) performed 2 maximal effort isometric pulls over two force plates sampling at 1000 Hz each. Peak force was scaled for body weight, and rate of force development was examined from 0-200ms. Results of the study show subjects' produced significantly greater scaled force with the left leg as compared to the right leg; however, no significant differences existed for rate of force development (RFD). Men exhibited significant differences between both …

Knowledge Of The Effects Of Alcohol On Fetal Development Among Women Of Childbearing Age., Mary Bales

Undergraduate Honors Theses

While Fetal Alcohol Syndrome Disorder is a recognized problem with alcohol ingestion during the formation of facial features, Fetal Alcohol Spectrum Disorders are not as widely recognized. These disorders result from exposure to alcohol throughout pregnancy when the brain and nervous system are developing. The resulting disorders include attention deficit disorders, social disorders, inappropriate behaviors, learning disorders, and intellectual disability. The incidence of children with alcohol-related disorders is increasing as evidenced by children needing special services in the educational systems. It is unknown how much alcohol ingestion is safe during pregnancy or how genetic factors are involved in the development …

7,8-Dihydroxyflavone, A Selective Tyrosine Kinase Receptor B Agonist And Bdnf Mimic, Promotes Angiogenesis., Jeremy Williams

Undergraduate Honors Theses

7,8-dihydroxyflavone (7,8-DHF), which is a member of the flavonoid family, is a selective tyrosine kinase receptor B (TrkB) agonist that has neurotrophic effects in various neurological diseases such as ischemic stroke and Parkinson’s disease [3]. In this study, we assessed the angiogeneic effect of 7,8-DHF in endothelial cells derived from resistance vessel of the brain. Angiogenesis by 7,8-DHF is an important factor that helps prevent and treat various ischemic diseases. In this study, we found that rat RV cells used in the experiment possess the TrkB receptor. Our data also demonstrates that 7,8-DHF is able to stimulate cell proliferation in …

Barthian Bliss In The Films Of Darren Aronofsky., Mark M. Hogstrom

Undergraduate Honors Theses

In this essay I argue that the films of director Darren Aronofsky correspond to the Text of Bliss defined in Roland Barthes' The Pleasure of the Text. Using several aspects of audience reception to dissect Aronofsky’s films justifies identifying his oeuvre as texts of bliss: works that disquiet viewers by unsettling their assumptions of the world around them and their own relationships with it. This Barthes-based appropriation of literary theory to audience reception theory in Film Studies serves as an example of how personally-developed classification systems can be used to circumvent relying on popular opinion and corporate aims for guidance …