Digital Commons Network^™

An Examination Of Discrimination On Stress, Depression, And Oppression-Based Trauma During The Covid-19 Pandemic And The Racial Awakening Of 2020, Ardhys N. De Leon, Jacqueline Woerner, Robert D. Dvorak, Jonathan Cox, Tatiana D. Magri, Emma R. Hayden, Manik Ahuja, Angela M. Haeny

ETSU Faculty Works

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Background

Discrimination is a pervasive societal issue that monumentally impacts people of color (POC). Many Black, Asian, and Hispanic/Latinx individuals report experiencing race-based discrimination in their lifetime. Discrimination has previously been linked to adverse health outcomes among POC, including stress, depressive, and posttraumatic stress disorder symptoms. These health disparities are posited to have become exacerbated by COVID-19 and the racial awakening of 2020. The current study examined the short- and long-term effects of discrimination on stress, depression, and oppression-based trauma among POC.

Methods

Participants were (n = 398) who identified as Black, Indigenous, Hispanic/Latinx, and Asian completed an online self-report …

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Telehealth Acceptance Among Appalachian Respondents During Covid 19: A Secondary Data Analysis, Victoria Hood-Wells, Florence M. Weierbach, Amy Wahlquist, Janet M. Keener, Manik Ahuja, Hadii M. Mamudu

ETSU Faculty Works

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Purpose: The purpose of this study is to examine the relationship between telehealth use, telehealth satisfaction, and chronic medical conditions among residents living in Appalachian and non-Appalachian communities.

Sample: A COVID-19 public health survey was distributed via social media and healthcare clinics in the tri-state region of central Appalachia. Survey responses were limited to adults aged ≥18 years who consented to participate in the survey that self-identified as an individual with one or more chronic medical conditions (n=195).

Method: Simple descriptive statistics including frequencies, percentages, means, and standard deviations (SDs) were calculated for variables of interest both overall and by …

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Perceptions Of Risk For Covid-19 Among Individuals With Chronic Diseases And Stakeholders In Central Appalachia, Manik Ahuja, Hadii M. Mamudu, Florence M. Weierbach, Karilynn Dowling-Mcclay, David W. Stewart, Manul Awasthi, Timir K. Paul

ETSU Faculty Works

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Coronavirus disease 2019 (COVID-19) pandemic is rapidly evolving and is a serious public health threat worldwide. Timely and effective control of the pandemic is highly dependent on preventive approaches. Perception of risk is a major determinant of health behavior. The current study explores the association between actual risk and perceived risk for one’s self, family/friends and friends, and community. A questionnaire was administered to participants in Central Appalachia (n = 102). The actual risk was based on the number of chronic conditions of the following conditions: hypertension, heart disease, cancer, diabetes, and chronic obstructive pulmonary disease. Participants were also queried …

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Blockade Of Sars-Cov-2 Spike Protein-Mediated Cell–Cell Fusion Using Covid-19 Convalescent Plasma, Ling Wang, Juan Zhao, Lam N.T. Nguyen, Lam N.T. Nguyen, James L. Adkins, Madison Schank, Sushant Khanal, Xindi Dang, Dechao Cao, Bal K. C. Thakuri, Zeyuan Lu, Jinyu Zhang, Yi Zhang, Xiao Y. Wu, Mohamed El Gazzar, Shunbin Ning, Jonathan P. Moorman, Zhi Q. Yao

ETSU Faculty Works

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The recent COVID-19 pandemic poses a serious threat to global public health, thus there is an urgent need to define the molecular mechanisms involved in SARS-CoV-2 spike (S) protein-mediated virus entry that is essential for preventing and/or treating this emerging infectious disease. In this study, we examined the blocking activity of human COVID-19 convalescent plasma by cell–cell fusion assays using SARS-CoV-2-S-transfected 293 T as effector cells and ACE2-expressing 293 T as target cells. We demonstrate that the SARS-CoV-2 S protein exhibits a very high capacity for membrane fusion and is efficient in mediating virus fusion and entry into target cells. …

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Symptoms-Based Fuzzy-Logic Approach For Covid-19 Diagnosis, Maad Shatnawi, Anas Shatnawi, Zakarea Alshara, Ghaith Husari

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The coronavirus (COVID-19) pandemic has caused severe adverse effects on the human life and the global economy affecting all communities and individuals due to its rapid spreading, increase in the number of affected cases and creating severe health issues and death cases worldwide. Since no particular treatment has been acknowledged so far for this disease, prompt detection of COVID-19 is essential to control and halt its chain. In this paper, we introduce an intelligent fuzzy inference system for the primary diagnosis of COVID-19. The system infers the likelihood level of COVID-19 infection based on the symptoms that appear on the …

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Hydroxychloroquine: A Comprehensive Review And Its Controversial Role In Coronavirus Disease 2019, Pankaj Bansal, Amandeep Goyal, Austin Cusick, Shubham Lahan, Harpal S. Dhaliwal, Poonam Bhyan, Pradnya B. Bhattad, Fawad Aslam, Sagar Ranka, Tarun Dalia, Lovely Chhabra, Devang Sanghavi, Bhavin Sonani, John M. Davis

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Hydroxychloroquine, initially used as an antimalarial, is used as an immunomodulatory and anti-inflammatory agent for the management of autoimmune and rheumatic diseases such as systemic lupus erythematosus. Lately, there has been interest in its potential efficacy against severe acute respiratory syndrome coronavirus 2, with several speculated mechanisms. The purpose of this review is to elaborate on the mechanisms surrounding hydroxychloroquine. The review is an in-depth analysis of the antimalarial, immunomodulatory, and antiviral mechanisms of hydroxychloroquine, with detailed and novel pictorial explanations. The mechanisms of hydroxychloroquine are related to potential cardiotoxic manifestations and demonstrate potential adverse effects when used for coronavirus …

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Oxidative Stress, Proton Fluxes, And Chloroquine/Hydroxychloroquine Treatment For Covid-19, Christina B. Klouda, William L. Stone

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Chloroquine (CQ) and hydroxychloroquine (HCQ) have been proposed as treatments for COVID-19. These drugs have been studied for many decades, primarily in the context of their use as antimalarials, where they induce oxidative stress-killing of the malarial parasite. Less appreciated, however, is evidence showing that CQ/HCQ causes systemic oxidative stress. In vitro and observational data suggest that CQ/HCQ can be repurposed as potential antiviral medications. This review focuses on the potential health concerns of CQ/HCQ induced by oxidative stress, particularly in the hyperinflammatory stage of COVID-19 disease. The pathophysiological role of oxidative stress in acute respiratory distress syndrome (ARDS) has …

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Remote Teaching Doesn't Come Without Challenges, Mayra Almodóvar-López, Julia Teresa Atiles, Aleida Chavarría-Vargas, Maria Jose Dias, Irma Zúñiga-León

ETSU Faculty Works

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Creative Commons: Reconocimiento, No Comercial, Sin Obra Derivada 3.0 Costa Rica. Las autorizaciones adicionales a las aquí delimitadas se pueden obtener en el correo: educare@una.cr Analysis of challenges faced by early childhood education teachers of 3 to 6 years old as a result of the suspension of face-to-face educational services due to COVID-19, and the implications in teacher education and professional development.

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