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Articles 1 - 30 of 40
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Periplasmic Cleavage And Modification Of The 1-Phosphate Group Of Helicobacter Pylori Lipid A, An X. Tran, Mark J. Karbarz, Xiaoyuan Wang, Christian R.H. Raetz, Sara C. Mcgrath, Robert J. Cotter, M. Stephen Trent
Periplasmic Cleavage And Modification Of The 1-Phosphate Group Of Helicobacter Pylori Lipid A, An X. Tran, Mark J. Karbarz, Xiaoyuan Wang, Christian R.H. Raetz, Sara C. Mcgrath, Robert J. Cotter, M. Stephen Trent
ETSU Faculty Works
Pathogenic bacteria modify the lipid A portion of their lipopolysaccharide to help evade the host innate immune response. Modification of the negatively charged phosphate groups of lipid A aids in resistance to cationic antimicrobial peptides targeting the bacterial cell surface. The lipid A of Helicobacter pylori contains a phosphoethanolamine (pEtN) unit directly linked to the 1-position of the disaccharide backbone. This is in contrast to the pEtN units found in other pathogenic Gram-negative bacteria, which are attached to the lipid A phosphate group to form a pyrophosphate linkage. This study describes two enzymes involved in the periplasmic modification of the …
Mitogen-Activated Protein Kinases And Mitogen-Activated Protein Kinase Phosphatases Mediate The Inhibitory Effects Of All-Trans Retinoic Acid On The Hypertrophic Growth Of Cardiomyocytes, Ants Palm-Leis, Ugra S. Singh, Bradley S. Herbelin, Greg D. Olsovsky, Kenneth M. Baker, Jing Pan
Mitogen-Activated Protein Kinases And Mitogen-Activated Protein Kinase Phosphatases Mediate The Inhibitory Effects Of All-Trans Retinoic Acid On The Hypertrophic Growth Of Cardiomyocytes, Ants Palm-Leis, Ugra S. Singh, Bradley S. Herbelin, Greg D. Olsovsky, Kenneth M. Baker, Jing Pan
ETSU Faculty Works
All-trans retinoic acid (RA) has been implicated in mediation of cardiac growth inhibition in neonatal cardiomyocytes. However, the associated signaling mechanisms remain unclear. Utilizing neonatal cardiomyocytes, we demonstrated that RA suppressed the hypertrophic features induced by cyclic stretch or angiotensin II (Ang II). Cyclic stretch- or Ang II-induced activation of extracellular signal-regulated kinase 1/2 (ERK1/2), C-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase (MAP kinase) was dose- and time-dependently inhibited by RA. Significant inhibition was observed by 5 μM RA, from 8 to 24 h of pretreatment. This inhibitory effect was not mediated at the level of mitogen-activated protein …
2004 December 13 - Staff Senate Minutes, Staff Senate, East Tennessee State University
2004 December 13 - Staff Senate Minutes, Staff Senate, East Tennessee State University
Staff Senate Agendas and Minutes
No abstract provided.
Interaction Of Calcium-Bound C-Reactive Protein With Fibronectin Is Controlled By Ph: In Vivo Implications, Madathilparambil V. Suresh, Sanjay K. Singh, Alok Agrawal
Interaction Of Calcium-Bound C-Reactive Protein With Fibronectin Is Controlled By Ph: In Vivo Implications, Madathilparambil V. Suresh, Sanjay K. Singh, Alok Agrawal
ETSU Faculty Works
C-reactive protein (CRP) binds with high affinity to fibronectin (Fn), a major component of the extracellular matrix (ECM), but at physiological pH the binding is inhibited by calcium ions (Ca2+). Because CRP circulates in the blood in Ca2+-bound form, the occurrence of CRP-Fn interactions in vivo has been doubtful. To define the basis of inhibition of CRP-Fn interaction by Ca2+ at pH 7.0, we hypothesized that Fn-binding site on CRP consisted of amino acids co-ordinating Ca2+. Site-directed mutagenesis of amino acids co-ordinating Ca2+ drastically decreased the binding of CRP to Fn, indicating that the Ca 2+-binding site indeed formed the …
2004 December 6 - Faculty Senate Agenda And Minutes, Faculty Senate, East Tennessee State University
2004 December 6 - Faculty Senate Agenda And Minutes, Faculty Senate, East Tennessee State University
Faculty Senate Agendas and Minutes
No abstract provided.
2004 November 22 - Faculty Senate Agenda And Minutes, Faculty Senate, East Tennessee State University
2004 November 22 - Faculty Senate Agenda And Minutes, Faculty Senate, East Tennessee State University
Faculty Senate Agendas and Minutes
No abstract provided.
2004 November 8 - Staff Senate Minutes, Staff Senate, East Tennessee State University
2004 November 8 - Staff Senate Minutes, Staff Senate, East Tennessee State University
Staff Senate Agendas and Minutes
No abstract provided.
2004 November 8 - Faculty Senate Agenda And Minutes, Faculty Senate, East Tennessee State University
2004 November 8 - Faculty Senate Agenda And Minutes, Faculty Senate, East Tennessee State University
Faculty Senate Agendas and Minutes
No abstract provided.
2004 October 25 - Faculty Senate Agenda And Minutes, Faculty Senate, East Tennessee State University
2004 October 25 - Faculty Senate Agenda And Minutes, Faculty Senate, East Tennessee State University
Faculty Senate Agendas and Minutes
No abstract provided.
2004 October 11 - Staff Senate Minutes, Staff Senate, East Tennessee State University
2004 October 11 - Staff Senate Minutes, Staff Senate, East Tennessee State University
Staff Senate Agendas and Minutes
No abstract provided.
2004 October 4 - Faculty Senate Minutes, Faculty Senate, East Tennessee State University
2004 October 4 - Faculty Senate Minutes, Faculty Senate, East Tennessee State University
Faculty Senate Agendas and Minutes
No abstract provided.
Review Of Historical Encyclopedia Of American Labor, Rebecca Tolley
Review Of Historical Encyclopedia Of American Labor, Rebecca Tolley
ETSU Faculty Works
Review of Historical Encyclopedia of American Labor. Robert Weir and James P. Hanlan Greenwood. 2004. 2v, 0313318409, $175.00
Optically Thick Clumps – Not The Solution To The Wolf-Rayet Wind Momentum Problem?, J. Brown, J. Cassinelli, Q. Li, A. Kholtygin, Richard Ignace
Optically Thick Clumps – Not The Solution To The Wolf-Rayet Wind Momentum Problem?, J. Brown, J. Cassinelli, Q. Li, A. Kholtygin, Richard Ignace
ETSU Faculty Works
The hot star wind momentum problem eta = M-upsiloninfinity/(L/c) much greater than 1 is revisited, and it is shown that the conventional belief, that it can be solved by a combination of clumping of the wind and multiple scattering of photons, is not self-consistent for optically thick clumps. Clumping does reduce the mass loss rate. M, and hence the momentum supply, required to generate a specified radio emission measure epsilon, while multiple scattering increases the delivery of momentum from a specified stellar luminosity L. However, in the case of thick clumps, when combined the two effects act in opposition rather …
Mapk-Dependent Regulation Of Il-1-And Β-Adrenoreceptor-Induced Inflammatory Cytokine Production From Mast Cells: Implications For The Stress Response, David S. Chi, S. Matthew Fitzgerald, Shannon Pitts, Karen Cantor, Ellis King, Steve A. Lee, Shau Ku Huang, Guha Krishnaswamy
Mapk-Dependent Regulation Of Il-1-And Β-Adrenoreceptor-Induced Inflammatory Cytokine Production From Mast Cells: Implications For The Stress Response, David S. Chi, S. Matthew Fitzgerald, Shannon Pitts, Karen Cantor, Ellis King, Steve A. Lee, Shau Ku Huang, Guha Krishnaswamy
ETSU Faculty Works
Background: Catecholamines, such as epinephrine, are elaborated in stress responses, and mediate vasoconstriction to cause elevation in systemic vascular resistance and blood pressure. Our previous study has shown that IL-1 can induce mast cells to produce proinflammatory cytokines which are involved in atherogenesis. The aim of this study was to determine the effects of epinephrine on IL-1-induced proatherogenic cytokine production from mast cells. Results: Two ml of HMC-1 (0.75 × 106 cells/ml) were cultured with epinephrine (1 × 10-5 M) in the presence or absence of IL-1β (10 ng/ml) for 24 hrs. HMC-1 cultured alone produced none to trace amounts …
2004 September 20 - Faculty Senate Agenda And Minutes, Faculty Senate, East Tennessee State University
2004 September 20 - Faculty Senate Agenda And Minutes, Faculty Senate, East Tennessee State University
Faculty Senate Agendas and Minutes
No abstract provided.
Differential Regulation Of Matrix Metalloproteinase-2 And -9 Expression And Activity In Adult Rat Cardiac Fibroblasts In Response To Interleukin-1Β, Zhonglin Xie, Mahipal Singh, Krishna Singh
Differential Regulation Of Matrix Metalloproteinase-2 And -9 Expression And Activity In Adult Rat Cardiac Fibroblasts In Response To Interleukin-1Β, Zhonglin Xie, Mahipal Singh, Krishna Singh
ETSU Faculty Works
Matrix metalloproteinases (MMPs), a family of endoproteinases, are implicated in cardiac remodeling. Interleukin-1β (IL-1β), which is increased in the heart following myocardial infarction, increases expression and activity of MMP-2 (gelatinase A) and -9 (gelatinase B) in cardiac fibroblasts. Previously, we have shown that IL-1β activates ERK1/2, JNKs, and protein kinase C (PKC). However, signaling pathways involved in the regulation of MMP-2 and -9 expression and activity are not yet well understood. Using adult rat cardiac fibroblasts, we show that inhibition of ERK1/2 and JNKs inhibits IL-1β-stimulated increases in MMP-9, not MMP-2, expression and activity. Chelerythrine, an inhibitor of PKC, inhibited …
2004 September 13 - Staff Senate Agenda And Minutes, Staff Senate, East Tennessee State University
2004 September 13 - Staff Senate Agenda And Minutes, Staff Senate, East Tennessee State University
Staff Senate Agendas and Minutes
No abstract provided.
2004 August 30 - Faculty Senate Minutes, Faculty Senate, East Tennessee State University
2004 August 30 - Faculty Senate Minutes, Faculty Senate, East Tennessee State University
Faculty Senate Agendas and Minutes
No abstract provided.
2004 August 9 - Staff Senate Agenda And Minutes, Staff Senate, East Tennessee State University
2004 August 9 - Staff Senate Agenda And Minutes, Staff Senate, East Tennessee State University
Staff Senate Agendas and Minutes
No abstract provided.
2004 July 12 - Staff Senate Agenda And Minutes, Staff Senate, East Tennessee State University
2004 July 12 - Staff Senate Agenda And Minutes, Staff Senate, East Tennessee State University
Staff Senate Agendas and Minutes
No abstract provided.
Technology Based Business Incubators: Living Laboratories For Entrepreneurial Students, Andrew Czuchry, W. Andrew Clark
Technology Based Business Incubators: Living Laboratories For Entrepreneurial Students, Andrew Czuchry, W. Andrew Clark
ETSU Faculty Works
Those teaching entrepreneurship to engineering and technology students are faced with the challenge of converting theory into learning opportunities that provide real-world-practical experience. Although the literature stresses the need for experiential learning through group and field projects and case studies, the potential of capitalizing on technology-based business incubators as living laboratories has not been fully utilized. The purpose of this paper is to suggest a conceptual framework for closing this gap. This framework is based upon our experience working with graduate student teams on projects with the Oak Ridge National Laboratories Center for Entrepreneurial Growth and East Tennessee State University’s …
Diverse Cross Functional Student Teams: A Teaching Tool For Enhanced Learning, Craig Turner, Keith Johnson, W. Andrew Clark
Diverse Cross Functional Student Teams: A Teaching Tool For Enhanced Learning, Craig Turner, Keith Johnson, W. Andrew Clark
ETSU Faculty Works
Traditional engineering and science teaching methodology has been to train like-minded students within the discipline of their respective majors. Curriculum time constraints, however, limit the number and nature of out of discipline elective courses. As a result, students are well trained within their respective fields of study but lack the breadth of experience in interacting with other diverse disciplines. Industry, particularly technology-based companies, has observed that solutions to problems have a greater probability of success when all interested parties (purchasing, innovation, marketing, sales, manufacturing, etc.) have input in developing a plan to achieve a desired corporate outcome. It is through …
2004 June 14 - Staff Senate Agenda And Minutes, Staff Senate, East Tennessee State University
2004 June 14 - Staff Senate Agenda And Minutes, Staff Senate, East Tennessee State University
Staff Senate Agendas and Minutes
No abstract provided.
2004 May 10 - Staff Senate Agenda And Minutes, Staff Senate, East Tennessee State University
2004 May 10 - Staff Senate Agenda And Minutes, Staff Senate, East Tennessee State University
Staff Senate Agendas and Minutes
No abstract provided.
2004 April 26 - Faculty Senate Agenda, Faculty Senate, East Tennessee State University
2004 April 26 - Faculty Senate Agenda, Faculty Senate, East Tennessee State University
Faculty Senate Agendas and Minutes
No abstract provided.
2004 April 12 - Staff Senate Agenda And Minutes, Staff Senate, East Tennessee State University
2004 April 12 - Staff Senate Agenda And Minutes, Staff Senate, East Tennessee State University
Staff Senate Agendas and Minutes
No abstract provided.
Identification And Characterization Of A Novel Human Myeloid Inhibitory C-Type Lectin-Like Receptor (Micl) That Is Predominantly Expressed On Granulocytes And Monocytes, Andrew S.J. Marshall, Janet A. Willmen, Hsi Hsien Lin, David L. Williams, Siamon Gordon, Gordon D. Brown
Identification And Characterization Of A Novel Human Myeloid Inhibitory C-Type Lectin-Like Receptor (Micl) That Is Predominantly Expressed On Granulocytes And Monocytes, Andrew S.J. Marshall, Janet A. Willmen, Hsi Hsien Lin, David L. Williams, Siamon Gordon, Gordon D. Brown
ETSU Faculty Works
Inhibitory and activatory C-type lectin-like receptors play an important role in immunity through the regulation of leukocytes. Here, we report the identification and characterization of a novel myeloid inhibitory C-type lectin-like receptor (MICL) whose expression is primarily restricted to granulocytes and monocytes. This receptor, which contains a single C-type lectin-like domain and a cytoplasmic immunoreceptor tyrosine-based inhibitory motif, is related to LOX-1 (lectin-like receptor for oxidized low density lipoprotein-1) and the β-glucan receptor (Dectin-1) and is variably spliced and highly N-glycosylated. We demonstrate that it preferentially associates with the signaling phosphatases SHP-1 and SHP-2, but not with SHIP. Novel chimeric …
Dermatology For The Practicing Allergist: Tinea Pedis And Its Complications, Muhannad Al Hasan, S. Matthew Fitzgerald, Mahnaz Saoudian, Guha Krishnaswamy
Dermatology For The Practicing Allergist: Tinea Pedis And Its Complications, Muhannad Al Hasan, S. Matthew Fitzgerald, Mahnaz Saoudian, Guha Krishnaswamy
ETSU Faculty Works
Tinea pedis is a chronic fungal infection of the feet, very often observed in patients who are immuno-suppressed or have diabetes mellitus. The practicing allergist may be called upon to treat this disease for various reasons. Sometimes tinea infection may be mistaken for atopic dermatitis or allergic eczema. In other patients, tinea pedis may complicate allergy and asthma and may contribute to refractory atopic disease. Patients with recurrent cellulitis may be referred to the allergist/immunologist for an immune evaluation and discovered to have tinea pedis as a predisposing factor. From a molecular standpoint, superficial fungal infections may induce a type2 …
2004 March 15 - Faculty Senate Agenda, Faculty Senate, East Tennessee State University
2004 March 15 - Faculty Senate Agenda, Faculty Senate, East Tennessee State University
Faculty Senate Agendas and Minutes
No abstract provided.
2004 March 5 - Staff Senate Agenda And Minutes, Staff Senate, East Tennessee State University
2004 March 5 - Staff Senate Agenda And Minutes, Staff Senate, East Tennessee State University
Staff Senate Agendas and Minutes
No abstract provided.