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Regulation Of Steroid Sulfatase In Human Breast Cancer Cells And Screening Of Human Tissues For Steroid Sulfatase Status, Abhinav Chandra

Electronic Theses and Dissertations

Breast cancer is the most frequently occurring cancer in women and is the second leading cause of death. About 40% of breast cancers are hormone-dependent and require estrogen for their growth. The steroid sulfatase pathway is an important means of converting local inactive estrogens to their active forms, thus supporting tumor growth. A substantial amount of research has been performed in the design of steroid sulfatase inhibitors, but the regulation of steroid sulfatase has been largely overlooked. My goal was to study the regulation of steroid sulfatase by different steroid hormones, using two human breast cancer cell lines the hormone-dependent …