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Influencing The Inflammatory Response Through Multi-Scale Geometry, Antibiotic Release, And Fluid Management In A Textile-Based Biomaterial Wound Dressing, Elizabeth Gianino
Influencing The Inflammatory Response Through Multi-Scale Geometry, Antibiotic Release, And Fluid Management In A Textile-Based Biomaterial Wound Dressing, Elizabeth Gianino
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The total population of diagnosed and undiagnosed diabetes mellitus in the United states is expected to rise by 54% between the years of 2015 and 2030 contributing to $200 billion in health care expense. The exponential rise in common diabetic wounds, such as diabetic foot ulcers, puts a large population at risk for complications such as infection, amputation, and even death. Peripheral neuropathy leading to late diagnoses, patient non-compliance, and lack of holistic treatment options all contribute to complications with the incidence of new ulcer formation after treatment reaching 50%. This work explores the design, development, and in vitro evaluation …
Use Of Electrolyzed Water As A Topical Antimicrobial And Minimal Processing Technique For Fresh, Whole Peaches, Dylan Zachary Hopkins
Use Of Electrolyzed Water As A Topical Antimicrobial And Minimal Processing Technique For Fresh, Whole Peaches, Dylan Zachary Hopkins
All Theses
Three experiments were performed to enumerate the natural microflora on unwashed peaches, known as 'field' peaches, and to determine the efficacy of using acidified electrolyzed water as a topical antimicrobial to remove or reduce the number of the natural microflora or inoculated Listeria innocua from to peach surfaces. During the first experiment, field peaches were divided into four treatment groups: no wash (NW), tap water wash (TW), acidified electrolyzed water wash (AEW), and chlorinated water wash (CL). Peaches were dipped into each of the treatment solutions at ambient temperature and immediately removed (approximately 5 seconds). Peaches were then rinsed in …
Comparison Of Methods To Evaluate Chitosan As An Antimicrobial Against Listeria Spp. Cultures, Scott Hartley
Comparison Of Methods To Evaluate Chitosan As An Antimicrobial Against Listeria Spp. Cultures, Scott Hartley
All Theses
The antimicrobial properties of a chitosan-coated vacuum-packaged pouch were tested against Listeria monocytogenes (LM) inoculated on frankfurters. A 1.5% chitosan solution was successfully coated onto a corona-treated poly/nylon based film and then heat-sealed to form a pouch. An initial 5 log CFU/mL population of LM was used to inoculate a frankfurter in the pouch, which was then vacuum-sealed and stored at 4¡ and 13¡ C for a period of 8 weeks, with bacteria enumeration performed on weekly intervals. An uncoated pouch was tested as a control. It was found that the chitosan-coated pouches did not exhibit any antimicrobial properties against …
Application Of Nanotechnology For Targeted Delivery Of Antibacterial Enzymes And For Enzyme-Based Coatings On Medical Devices And Implants, Rohan Satishkumar
Application Of Nanotechnology For Targeted Delivery Of Antibacterial Enzymes And For Enzyme-Based Coatings On Medical Devices And Implants, Rohan Satishkumar
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The frequency of S. aureus infection and subsequent biofilm formation associated with vascular catheterization has been increasing in recent years and often begins as a local colonization at the site of the catheter insertion. Antimicrobial enzymes and peptides, which are effective against a broad range of pathogens and low rates of resistance, have attracted attention as promising alternative candidates in treatment of infections caused by antibiotic resistant bacteria. The use of nanoparticles as carriers for enzymes, in addition to their size, charge, high surface area per volume etc. offers targeted delivery of enzymes to pathogenic bacteria. We proposed to use …
The Antibacterial Properties Of Brookite Phase Titanium Dioxide Nanoparticles Against Methicillin-Resistant Staphylococcus Aureus, Rupal Shah
All Theses
Staphylococcus aureus (S. aureus), a major human pathogen, is a common cause of infections worldwide due to its high virulence intensity. By adapting to rapidly changing and uniformly hostile environments, strains of S. aureus acquire resistance to antimicrobial agents shortly after their exposure. For example, within a year of its introduction, S. aureus developed resistance to methicillin which triggered the development of other antimicrobial treatments. In spite of the various antibiotics currently used to treat methicillin-resistant S. aureus (MRSA) infections, antimicrobial resistance is an unavoidable consequence due to the selective pressure of antibiotic exposure. Thus, other prevention modalities are warranted …