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Effects Of The Renin-Angiotensin Blockade On Renal Functions, Renal Norepinephrine Contents And Oxidative Stress In Cyclosporine Induced Nephrosis Rats, Suvaporn Panasjaroen, Sarinee Kalandakanond-Thongsong, Chollada Buranakarl
Effects Of The Renin-Angiotensin Blockade On Renal Functions, Renal Norepinephrine Contents And Oxidative Stress In Cyclosporine Induced Nephrosis Rats, Suvaporn Panasjaroen, Sarinee Kalandakanond-Thongsong, Chollada Buranakarl
The Thai Journal of Veterinary Medicine
The experiment was conducted to investigate the effects of renin-angiotensin blockade on renal function, renal norepinephrine (NE) contents and renal oxidative stress in Cyclosporine A (CsA) induced renal impairment in rats. Rats were assigned into three groups; group 1 (control group), receiving vehicle (propylene glycol) 1 ml/kg./day, subcutaneously (s/c). for 28 days; group 2 (CsA group), receiving CsA 15 mg/kg/day, s/c for 28 days; group 3 (CsA and losartan (LST) group), receiving CsA 15 mg/kg./day, s/c with the administration of LST 10 mg/k.g./day orally for 28 days. The results showed that CsA administration alone elevated mean arterial pressure (MAP), reduced …