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California Polytechnic State University, San Luis Obispo

Hyperglycemia

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Effect Of Oral Lipids On Blood Glucose, Tyler R. Knisley Jun 2013

Effect Of Oral Lipids On Blood Glucose, Tyler R. Knisley

Biomedical Engineering

Diabetes mellitus is a disease in which insulin hormone is ineffective or no longer produced. Multiple pathophysiologies can cause either insulin dependent diabetes mellitus (IDDM) or insulin independent diabetes mellitus (IIDM), which can lead to chronic hyperglycemia and an array of short and long term health risks. Prior research has shown that IDDM patients have dyslipidemia, and experiments infusing lipids directly into the blood result in heightened insulin resistance. The hypothesis that dyslipidemia increases insulin resistance was tested by performing oral glucose tolerance tests across three treatment conditions. Participants were nondiabetic college-aged students. Data from a control group was gathered …


Implementation And Assessment Of Hyperglycemic Conditions For The Creation Of A Diabetic Blood Vessel Mimic, Vikramaditya Mediratta Jun 2011

Implementation And Assessment Of Hyperglycemic Conditions For The Creation Of A Diabetic Blood Vessel Mimic, Vikramaditya Mediratta

Master's Theses

Introduction: Diabetes Mellitus is a metabolic disorder that affects a person’s ability to either produce insulin (Type I diabetes mellitus) or properly use insulin (Type II diabetes mellitus) in order to maintain adequate blood glucose levels. The most severe diabetic complications arise due to hyperglycemia – a state of extremely high blood glucose levels – such as, coronary artery disease (CAD), in which coronary stent therapy is a popular method of treatment. However, research has shown a high rate of in-stent restenosis in diabetic patients with CAD, most likely due to activation of cellular adhesion molecules on endothelial cells exposed …