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The Cholera-Fiend: Cheap Fiction, Medical Professionals, And Entertainment, Sariah Fales Harrington
The Cholera-Fiend: Cheap Fiction, Medical Professionals, And Entertainment, Sariah Fales Harrington
Theses and Dissertations
First published in 1849, Charles Averill’s The Cholera-Fiend follows three villains as they attempt to artificially propagate cholera for their own villainous purposes in New York City. Gumbo, a Black servant to one of the villains, is meant to be the humorous relief in the text, but Gumbo experiences a calculated dehumanization from human to disabled, which causes him to be more at-risk for a health crisis—such as a tapeworm or cholera—than his white counterparts. Through analyzing the genre of cheap fiction, the views of medical professionals towards Black bodies, and other ways Black bodies were used as entertainment, I …
The Inhibition Of Valproic Acid-Induced Negative Neurodevelopmental Outcomes Through Nrf2-Mediated Redox Regulation, Ted Brenton Piorczynski
The Inhibition Of Valproic Acid-Induced Negative Neurodevelopmental Outcomes Through Nrf2-Mediated Redox Regulation, Ted Brenton Piorczynski
Theses and Dissertations
Valproic acid (VPA) is a commonly prescribed antiepileptic drug that causes negative neurodevelopmental outcomes, including neural tube defects (NTDs) and neurodevelopmental disorders, in fetuses exposed to it. While the exact mechanism by which VPA causes defects is unknown, research has shown that VPA increases the production of reactive oxygen species (ROS) that lead to redox dysregulation. We hypothesize that VPA causes negative neurodevelopmental outcomes through the disruption of redox-sensitive signaling pathways that are critical for proper embryonic development, and that protection from the VPA-induced redox disruption may decrease the prevalence of the observed defects. Time-bred mice were treated with 3H-1,2-dithiole-3-thione …