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Articles 1 - 30 of 60
Full-Text Articles in Entire DC Network
Protocol For Management Of Hypertension By Family Practitioners, Badar Sabir Ali, R Qureshi, R H. Dhanani
Protocol For Management Of Hypertension By Family Practitioners, Badar Sabir Ali, R Qureshi, R H. Dhanani
Department of Family Medicine
No abstract provided.
Accumulation Of Methotrexate In Human Tissues Following High-Dose Methotrexate Therapy, M P. Iqbal
Accumulation Of Methotrexate In Human Tissues Following High-Dose Methotrexate Therapy, M P. Iqbal
Department of Biological & Biomedical Sciences
Methotrexate concentration was analyzed in a number of tissues of a patient of osteogenic sarcoma who had been on high-dose methotrexate therapy for nearly 6 months. Gall bladder and kidney contained the highest concentration of the drug, followed by testis, small intestine, skeletal muscle, bone marrow, lung, spleen, heart and liver. Although, compared to kidney the liver contained relatively small amount of the drug, yet nearly 1/5th of the total drug in liver was in bound form. This bound form of methotrexate is most likely associated with multiple forms of dihydrofolate reductase. The total concentration of methotrexate in kidney is …
Moyamoya Disease Presenting With Intracranial Haemorrhage, Ali Akbar, Aftab Qureshi, Rashid Jooma
Moyamoya Disease Presenting With Intracranial Haemorrhage, Ali Akbar, Aftab Qureshi, Rashid Jooma
Section of Neurosurgery
No abstract provided.
Evaluation And Management Of Otitis Media In Children, N S. Ali
Evaluation And Management Of Otitis Media In Children, N S. Ali
Community Health Sciences
No abstract provided.
Preoperative Work Up: Are The Requirements Different In A Developing Country?, K M. Pal, I A. Khan, B Safdar
Preoperative Work Up: Are The Requirements Different In A Developing Country?, K M. Pal, I A. Khan, B Safdar
Department of Surgery
In developing countries there is a tendency to advocate routine testing in asymptomatic healthy patients to identify undocumented significant medical conditions. A retrospective review of pre- operative laboratory investigations undertaken in patients attending the General Surgical department was performed. Three hundred and twenty patients case notes were reviewed, patients were selected on the basis of common general surgical procedures. Two hundred and sixteen patients (67.5%) did not have any associated medical illness on history and physical examination. Analysis of laboratory results showed that 42/216 (19.4%) had low hemoglobin. An abnormal chest X-ray was the next common abnormality 11/103 (10.6%). Mild …
Reflection On School Visit, Qamar Safdar
Reflection On School Visit, Qamar Safdar
Institute for Educational Development, Karachi
No abstract provided.
Headteachers As School Leaders In Pakistan, Muhammad Memon, Fauzia Reza
Headteachers As School Leaders In Pakistan, Muhammad Memon, Fauzia Reza
Institute for Educational Development, Karachi
No abstract provided.
Primary Cutaneous Actinomycosis, Anjum Kanjee, Zamaz Wahid, Shahid Pervez
Primary Cutaneous Actinomycosis, Anjum Kanjee, Zamaz Wahid, Shahid Pervez
Department of Pathology and Laboratory Medicine
No abstract provided.
Benzodiazepine Self-Poisoning In Pakistan: Implications For Prevention And Harm Reduction, M M. Khan, Hashim Reza
Benzodiazepine Self-Poisoning In Pakistan: Implications For Prevention And Harm Reduction, M M. Khan, Hashim Reza
Department of Psychiatry
The pattern of all index admissions for benzodiazepine self-poisoning to a university hospital in Karachi, Pakistan are described. Of the 329 medication self-poisoning cases, 84% were benzodiazepine overdoses. Diazepam was the preferred drug in 69% of these cases, with majority ingesting between 20-30 tablets of 5 mg each, 44% bought the benzodiazepine over the counter (OTC) for the purpose of overdose. The preference for benzodiazepines over analgesics (as freely available) may be related to the motives underlying parasuicide acts and their popularity as 'sleeping pills' in Pakistan. Educating the 'chemist' and limiting the number of tablets dispensed at a time …
Role Of Fibreoptic Bronchoscopy In The Management Of Immunocompromised Patients With Pulmonary Infiltrates, S F. Hussain, I Malik, J A. Khan
Role Of Fibreoptic Bronchoscopy In The Management Of Immunocompromised Patients With Pulmonary Infiltrates, S F. Hussain, I Malik, J A. Khan
Section of Pulmonary & Critical Care
Immunocompromised patients are prone to develop various pulmonary complications. The range of diagnostic possibilities is wide, infection being the commonest cause. Non-invasive diagnostic tests are often unrewarding. In this study, we have evaluated the diagnostic efficacy and safety of fibreoptic bronchoscopy in immunocompromised patients with pulmonary infiltrates. Patients tolerated the procedure well. This technique identified the etiology in up tp 75% of cases. After treatment based on the result of bronchoscopy, 63% patients improved and were discharged.
Urinary N-Acetyl-Beta-D-Glucosaminidase In Rheumatoid Arthritis, M P. Iqbal, A A. Ali, M A. Waqar, N Mehboobali
Urinary N-Acetyl-Beta-D-Glucosaminidase In Rheumatoid Arthritis, M P. Iqbal, A A. Ali, M A. Waqar, N Mehboobali
Department of Biological & Biomedical Sciences
Excretion of urinary N-acetyl beta-D-glucosaminidase (NAG) and its isoenzyme patterns were studied in two groups of patients with rheumatoid arthritis (RA) and in normal control subjects. Urine samples were collected from 30 seropositive RA patients, 19 seronegative RA patients, and 15 normal healthy subjects. All the patients and normal subjects were assessed to have normal liver and kidney functions. A small portion of the urine sample was dialyzed against 0.01 M phosphate buffer, pH 7.0 and NAG activity was monitored. Mean +/- SD values of urinary NAG in seropositive RA patients, in seronegative RA patients and in normal healthy subjects …
Development Of An Indigenous Screening Instrument In Pakistan: The Aga Khan University Anxiety And Depression Scale, B S. Ali, H Reza, M M. Khan, I Jehan
Development Of An Indigenous Screening Instrument In Pakistan: The Aga Khan University Anxiety And Depression Scale, B S. Ali, H Reza, M M. Khan, I Jehan
Community Health Sciences
The use of translations of instruments for detecting anxiety and depression continues to be debated. An indigenous screening instrument has been developed in Urdu for anxiety-depression syndromes at the Aga Khan University. It has been developed from the complaints of 150 anxious and depressed patients presenting to a non-speciality clinic and has been validated in 53 patients in a psychiatry clinic. The questionnaire has 25 items, 13 psychlogical and 12 somatic. At a score of 20 it has a sensitivity of 66%, a specificity of 79%, a positive predictive value of 83 and a negative predictive value of 60. In …
Bacterial Isolates From Neutropenic Febrile Pediatric Patients And Their Sensitivity Patterns To Antibiotics, F N. Bhatti, I A. Burney, M I. Moid, T Siddiqui
Bacterial Isolates From Neutropenic Febrile Pediatric Patients And Their Sensitivity Patterns To Antibiotics, F N. Bhatti, I A. Burney, M I. Moid, T Siddiqui
Section of Internal Medicine
Patients on cytotoxic therapy often develop neutropenia and fever. Our interest was to identify the common pathogens isolated from such patients and to study the sensitivity patterns of these organisms to the antibiotics used in their treatment. Thus, guidelines can be established by hospitals to identify which antibiotics can be used in the treatment of these patients when the results of cultures and sensitivities are not available. We conducted a retrospective study of neutropenic pediatrics presenting to AKUH from July, 1990 to June, 1996. A total of 153 isolates in 35 different patients were studied. Samples for culture were taken …
Spinal Cord Compression: Histologic Spectrum Of Lesions, I. N. Soomro, N.Kayani N.Kayani, Shahid Pervez, A. S. Hussainy, R. Ahmed, S. Muzaffar, S. A. Aziz, S. H. Hasan
Spinal Cord Compression: Histologic Spectrum Of Lesions, I. N. Soomro, N.Kayani N.Kayani, Shahid Pervez, A. S. Hussainy, R. Ahmed, S. Muzaffar, S. A. Aziz, S. H. Hasan
Department of Pathology and Laboratory Medicine
Histologic diagnosis ultimately determines the prognosis and treatment of lesions causing spinal cord compression. Modem imaging techniques have revolutionized the procedure of localizing lesions pre¬senting with signs and symptoms of spinal cord compression. As a result, these lesions are more accessible for fine needle aspiration and biopsy. A quick diagnosis is possible if cytologic preparation is made. Similarly, intraoperative frozen section facility not only provides rapid diagnosis, but also offers oppor tunity of appropriate management decision there and then. Histology in many cases needs help of special stains and immunocytochemistry. This study looks at the histologic spectrum of these lesions, …
Soft Tissue Sarcomas: Pattern Diagnosis Or Entity, Naasha Talati, Shahid Pervez
Soft Tissue Sarcomas: Pattern Diagnosis Or Entity, Naasha Talati, Shahid Pervez
Department of Pathology and Laboratory Medicine
Soft tissue sarcomas (STS) are a diverse and heterogeneous group of tumours The sub-classification of these tumours is of importance for both prognosis and treatment. Classically, sub- categorization is based purely on histomorphological grounds, but as new techniques evolve, a more, conclusive and accurate diagnosis can be made. This study describes the prevalence of soft tissue sarcomas in adults diagnosed at The Aga Khan University Hospital (AKUH) and the impact of immunohistochemistry(IHC) on the precise sub-categorization of these tumours. The study included 364 adults (age 16+) who were diagnosed as soft tissue sarcoma in the past six years (May 1991 …
Evaluation Of Chest Pain In General Practice, S Dodani
Evaluation Of Chest Pain In General Practice, S Dodani
Department of Family Medicine
No abstract provided.
Nocturnal Enuresis In Children, N S. Ali
Nocturnal Enuresis In Children, N S. Ali
Community Health Sciences
This common condition can be managed by the general practitioners. The key answer to nocturnal enuresis is nocturnal self-awakening and recently more emphasis is given on this which is an area of greatest promise. Behavioural modification in conjunction with an enuretic alarm also teaches this skill and has the highest cure rate and the lowest relapse rate. Enuretic alarms can be used any time from age 5 onwards. But drugs are only indicated when there is need for short term dryness e.g. when the child has to be away from home.
Pregnancy Unmasking Hypoparathyroidism, A Jabbar, L Samad, J Akhter, M A. Khan
Pregnancy Unmasking Hypoparathyroidism, A Jabbar, L Samad, J Akhter, M A. Khan
Section of Internal Medicine
No abstract provided.
Appendicitis: A Continuing Challenge, K M. Pal, A Khan
Appendicitis: A Continuing Challenge, K M. Pal, A Khan
Department of Surgery
Acute appendicitis is a common surgical emergency in urban setting, of a developing country. The computerised hospital patient database at Aga Khan University Hospital, Karachi, was utilised to obtain records of all adults with a histologically proven diagnosis of acute appendicitis. A review of patients treated over a 18 month period was undertaken. One hundred and three appendicectomies were performed for acute appendicitis during this period. The diagnosis was clinical in all cases. Investigations like leucocyte count and lower abdominal ultrasound scan were used to improve diagnostic accuracy without a clear advantage. A number of routine investigations like, haemoglobin estimation …
Hydatidosis: Experience With Hepatic And Pulmonary Hydatid Disease, T Pishori, R Azami, S M. Ali
Hydatidosis: Experience With Hepatic And Pulmonary Hydatid Disease, T Pishori, R Azami, S M. Ali
Department of Surgery
From 1989-1992, 35 cases comprising of 20 hepatic and 15 pulmonary hydatid cysts were seen. Four patients with pulmonary hydatid disease had previous or concomitant hepatic hydatidosis compared to no concomitant pulmonary hydatid disease in the hepatic group. Hepatic hydatid disease had a greater tendency to be right sides, infected and calcified. Anaphylactic reactions occurred in 3 of 20 patients with hepatic hydatid disease against none in 15 patients with pulmonary disease. Management consisted of evacuation, drainage and obliteration of the residual cavity by capittonage in the lung and omentoplasty in the liver. Two patients, one hepatic and one with …
Well Differentiated Hepatocellular Carcinoma Metastasizing To Jaw And Oral Cavity Within Six Months Of Primary Diagnosis., Nazma Afroze, Irshad N. Soomro, Shahid Pervez, Naila Kayani, Sheema H. Hasan
Well Differentiated Hepatocellular Carcinoma Metastasizing To Jaw And Oral Cavity Within Six Months Of Primary Diagnosis., Nazma Afroze, Irshad N. Soomro, Shahid Pervez, Naila Kayani, Sheema H. Hasan
Department of Pathology and Laboratory Medicine
No abstract provided.
Detection Of Mycobacterium Tuberculosis In Paraffin Embedded Intestinal Tissue Specimens By Polymerase Chain Reaction: Characterization Of Is6110 Element Negative Strains, Tariq Moatter, Shaper Mirza, Mohammad Shahid Siddiqui, Irshad Nabi Soomro
Detection Of Mycobacterium Tuberculosis In Paraffin Embedded Intestinal Tissue Specimens By Polymerase Chain Reaction: Characterization Of Is6110 Element Negative Strains, Tariq Moatter, Shaper Mirza, Mohammad Shahid Siddiqui, Irshad Nabi Soomro
Department of Pathology and Laboratory Medicine
Tuberculosis is still one of the most widespread infection known to mankind. Although lung is the predominant site of disease, a sizeable population in Pakistan gets intestinal disease. Clinical presentation, radiologic and endoscopic examination provide clues to the diagnosis. However, a definitive diagnosis requires biopsy material with granulomas and/or caseation complemented by acid fast staining and culture. There are many occasions when biopsy material is scanty and even in some intestinal resection cases histologic evaluation fails to confirm or rule out tuberculosis. Therefore, an investigation was conducted to assess the efficacy of PCR in the detection of mycobacterial DNA in …
Cholera In Children In Karachi From 1990 Through 1995: A Study Of Cases Admitted To A Tertiary Care Hospital, S Q. Nizami, B J. Farooqui
Cholera In Children In Karachi From 1990 Through 1995: A Study Of Cases Admitted To A Tertiary Care Hospital, S Q. Nizami, B J. Farooqui
Department of Paediatrics and Child Health
Although cholera is an endemic disease in Bangladesh, India and other countries, it was never a significant cause of gastroenteritis in Pakistan before 1988. Since then, cases of cholera are identified each year, both in adults and children in Pakistan. In order to see the contribution of Vibrio cholerae as a cause of gastroenteritis in children, we reviewed the cases of cholera admitted in the pediatric ward of the Aga Khan University Hospital, Karachi, Pakistan. Of 4346 children hospitalized with gastroenteritis during 1990 through 1995, 348 children (8%) were confirmed to have cholera. The youngest child with cholera was seven …
Tuberculosis Presenting As Polyarthritis, J A. Khan, M Y. Ahmadani
Tuberculosis Presenting As Polyarthritis, J A. Khan, M Y. Ahmadani
Section of Pulmonary & Critical Care
No abstract provided.
Principles Of Family Medicine, Riaz Qureshi
Principles Of Family Medicine, Riaz Qureshi
Department of Family Medicine
No abstract provided.
Primary Spinal T-Cell Rich B-Cell Lymphoma: A Case Report, Suhail Muzaffar Suhail Muzaffar, Irshad Nabi Soomro, Naila Kayani, Shahid Siddiqui, Yousuf A. Husein, Rashid Jooma
Primary Spinal T-Cell Rich B-Cell Lymphoma: A Case Report, Suhail Muzaffar Suhail Muzaffar, Irshad Nabi Soomro, Naila Kayani, Shahid Siddiqui, Yousuf A. Husein, Rashid Jooma
Department of Pathology and Laboratory Medicine
No abstract provided.
Pattern Of Malignant Tumors Observed In A University Hospital: A Retrospective Analysis, I A. Malik, W A. Khan, Z K. Khan
Pattern Of Malignant Tumors Observed In A University Hospital: A Retrospective Analysis, I A. Malik, W A. Khan, Z K. Khan
Section of Internal Medicine
A retrospective analysis of all malignant tumors observed in adults over a four-years period is presented. From January 1, 1989 to December 31, 1992, 2623 patients were coded by the Indexing and Coding Unit of Medical Records, The Aga Khan University Hospital to have cancer. Data presented reflect the relative frequency of different cancers seen at a single institution. Lung cancer was the commonest tumor observed in males. It was closely followed by head and neck cancer and lymphoma. In females, breast was the commonest cancer followed by ovarian and gallbladder. In comparison to the Western figures, an increased frequency …
Promoting Science Teacher Education Through Dissonance And Discrepancy, Nelofer Halai, Alan E. Wheeler
Promoting Science Teacher Education Through Dissonance And Discrepancy, Nelofer Halai, Alan E. Wheeler
Institute for Educational Development, Karachi
While inquiry in science teaching has found a great deal of acceptance (Colletet and Chiapetta, 1989), there is a growing recognition that educators need a wider repertoire of inquiry strategies applicable to various situations. One promising approach is through the use of so-called ‘dissonant’ or ‘discrepant events’. This concept of discrepancy can be traced to the early work of Festinger (1975) and his Theory of Cognitive Dissonance in which he stated that the creation of dissonance is psychologically very uncomfortable and motivates individuals to actively reduce the level of dissonance and thereby return to a state of greater equilibrium or …
Haemolytic Uraemic Syndrome In Childhood: An Experience Of 7 Years At The Aga Khan University, S H. Ibrahim, Z A. Bhutta, I A. Khan
Haemolytic Uraemic Syndrome In Childhood: An Experience Of 7 Years At The Aga Khan University, S H. Ibrahim, Z A. Bhutta, I A. Khan
Department of Paediatrics and Child Health
We reviewed the case records of all children admitted to the Aga Khan University Hospital (AKUH) with a diagnosis of Haemolytic Uremic Syndrome (HUS) over a 7 year period (July, 1988-June, 1995). A total of 33 patients were admitted to the Pediatric ward at (AKUH) with a median age of 16 months (range 4 months-9 years). 97% cases identified were of the classic variety and no familial case was identified. The mean duration of illness was 27 days, 39% had an illness > 28 days. Diarrhoea and prior antibiotic used was in 97% patients. Oliguria at admission was seen in 52.5% …
Smoking Among Males In A Low Socioeconomic Area Of Karachi, A T. Merchant, S P. Luby, G Perveen
Smoking Among Males In A Low Socioeconomic Area Of Karachi, A T. Merchant, S P. Luby, G Perveen
Community Health Sciences
Approximately half of the families in Pakistan reported having at least one smoker in 1992. Smokers were less educated, poorer and more likely to come from a rural background than non-smokers. The proportion of family earnings in poor families with marginal incomes, may be substantial. We conducted this survey to determine the prevalence of cigarette smoking in males over 15 years of age in Azam Basti, an urban squatter settlement of Karachi where 31% of the children less than 5 years old were malnourished. A pretested, structured questionnaire was administered to males aged fifteen years and above, from randomly selected …