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Vasopressin In Conjunction With Norepinephrine In Septic Shock: A Retrospective Cohort Study From A Low Middle-Income Country, Hussain Ahmed Raza, Ainan Arshad, Ahmed Ayaz, Mohummad H R. Raja, Fatima Gohar, Maria Khan, Bushra Jamil
Vasopressin In Conjunction With Norepinephrine In Septic Shock: A Retrospective Cohort Study From A Low Middle-Income Country, Hussain Ahmed Raza, Ainan Arshad, Ahmed Ayaz, Mohummad H R. Raja, Fatima Gohar, Maria Khan, Bushra Jamil
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Objectives: Guidelines recommend use of norepinephrine as the first-line treatment for fluid-refractory septic shock and if septic shock persists vasopressin may be initiated. Since there are limited data from low middle-income countries with high disease burden of sepsis, we aimed to compare the outcomes of using vasopressin adjunct to norepinephrine in comparison with norepinephrine alone.
Design: Retrospective cohort study.
Setting: Aga Khan University Hospital, Karachi, Pakistan.
Patients: Six-hundred fifty-three patients diagnosed with septic shock from January 2019 to December 2019, with 498 given norepinephrine only and 155 given norepinephrine-vasopressin combination.
Interventions: None.
Measurements and main results: Primary outcome was in-hospital …
Drug Induced Liver Injury Is Associated With High Mortality- A Study From A Tertiary Care Hospital In Pakistan, Adeel Abid, Faryal Subhani, Farhana Kayani, Safia Awan, Shahab Abid
Drug Induced Liver Injury Is Associated With High Mortality- A Study From A Tertiary Care Hospital In Pakistan, Adeel Abid, Faryal Subhani, Farhana Kayani, Safia Awan, Shahab Abid
Medical College Documents
Background and aim: In light of few established drug induced liver injury (DILI) registries, this study aims to evaluate the clinical spectrum and predictors of mortality and morbidity of hospitalized patients with suspected DILI.
Patients and methods: DILI cases were identified and categorized on basis of COIMS/RUCAM score and the exclusion of other liver diseases. Clinical and laboratory parameters were analyzed to identify the predictors of morbidity (prolonged hospital stay > 5 days) and mortality.
Results: Out of 462 patients, there were 264 (57.6%) males and the mean age of the cohort was 50.83 years (range: 20-94 years). DILI was classified …